2021
Scope of Practice of US Interventional Cardiologists from an Analysis of Medicare Billing Data
Murugiah K, Chen L, Castro-Dominguez Y, Khera R, Krumholz HM. Scope of Practice of US Interventional Cardiologists from an Analysis of Medicare Billing Data. The American Journal Of Cardiology 2021, 160: 40-45. PMID: 34610872, DOI: 10.1016/j.amjcard.2021.08.041.Peer-Reviewed Original Research
2020
Association Between Depressive Symptoms and Incident Cardiovascular Diseases
Harshfield EL, Pennells L, Schwartz JE, Willeit P, Kaptoge S, Bell S, Shaffer JA, Bolton T, Spackman S, Wassertheil-Smoller S, Kee F, Amouyel P, Shea SJ, Kuller LH, Kauhanen J, van Zutphen EM, Blazer DG, Krumholz H, Nietert PJ, Kromhout D, Laughlin G, Berkman L, Wallace RB, Simons LA, Dennison EM, Barr ELM, Meyer HE, Wood AM, Danesh J, Di Angelantonio E, Davidson KW. Association Between Depressive Symptoms and Incident Cardiovascular Diseases. JAMA 2020, 324: 2396-2405. PMID: 33320224, PMCID: PMC7739139, DOI: 10.1001/jama.2020.23068.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular DiseasesCohort StudiesCoronary DiseaseDepressionFemaleHumansIncidenceMaleMiddle AgedRisk FactorsStrokeConceptsCoronary heart diseaseHazard ratioStroke eventsCardiovascular diseaseCorresponding incidence ratesDepressive symptomsHigher depression scoresCHD eventsCVD eventsCVD incidencePooled analysisIncidence rateDepression scoresNonfatal coronary heart diseasePatient Health Questionnaire-2Epidemiological Studies Depression ScaleIncident cardiovascular diseasePHQ-2 scoreAdditional risk factorsBaseline depressive symptomsSelf-reported depressive symptomsCES-D scoresEmerging Risk Factors CollaborationIndividual participant dataUK Biobank
2019
Effects of Mobile Text Messaging on Glycemic Control in Patients With Coronary Heart Disease and Diabetes Mellitus
Huo X, Krumholz HM, Bai X, Spatz ES, Ding Q, Horak P, Zhao W, Gong Q, Zhang H, Yan X, Sun Y, Liu J, Wu X, Guan W, Wang X, Li J, Li X, Spertus JA, Masoudi FA, Zheng X. Effects of Mobile Text Messaging on Glycemic Control in Patients With Coronary Heart Disease and Diabetes Mellitus. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005805. PMID: 31474119, DOI: 10.1161/circoutcomes.119.005805.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsian PeopleBiomarkersBlood GlucoseChinaCoronary DiseaseCulturally Competent CareDiabetes MellitusExerciseFemaleGlycated HemoglobinHealth CommunicationHealthy LifestyleHumansHypoglycemic AgentsMaleMedication AdherenceMiddle AgedMotivationPatient Education as TopicRisk Reduction BehaviorSelf CareSingle-Blind MethodTelemedicineText MessagingTime FactorsTreatment OutcomeConceptsCoronary heart diseaseHeart diseaseGlycemic controlIntervention groupUsual careDiabetes mellitusBlood glucosePhysical activityControl groupText message-based interventionBlood pressure controlProportion of patientsRisk factor managementGood glycemic controlSystolic blood pressureBody mass indexText messaging programsText message interventionMobile health interventionsSecondary outcomesBlood pressurePrimary outcomeLDL cholesterolMass indexMedication adherenceEffect of Text Messaging on Risk Factor Management in Patients With Coronary Heart Disease
Zheng X, Spatz ES, Bai X, Huo X, Ding Q, Horak P, Wu X, Guan W, Chow CK, Yan X, Sun Y, Wang X, Zhang H, Liu J, Li J, Li X, Spertus JA, Masoudi FA, Krumholz HM. Effect of Text Messaging on Risk Factor Management in Patients With Coronary Heart Disease. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005616. PMID: 30998400, DOI: 10.1161/circoutcomes.119.005616.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsian PeopleBlood PressureChinaCoronary DiseaseCulturally Competent CareFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedPatient Education as TopicRisk AssessmentRisk FactorsSecondary PreventionSingle-Blind MethodTelemedicineText MessagingTime FactorsTreatment OutcomeConceptsCoronary heart diseaseSystolic blood pressureBody mass indexBlood pressureHeart diseaseSecondary preventionIntervention groupPhysical activityEnd pointSmoking statusMass indexControl groupPrimary end pointRisk factor controlSecondary end pointsRisk factor managementLDL-C levelsDisease-specific knowledgeMobile phone textMobile health technologyUsual careDiabetes mellitusMedication adherenceRisk factorsFactor management
2017
Design and rationale of the Cardiovascular Health and Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study: two randomised controlled trials of text messaging to improve secondary prevention for coronary heart disease and diabetes
Huo X, Spatz ES, Ding Q, Horak P, Zheng X, Masters C, Zhang H, Irwin ML, Yan X, Guan W, Li J, Li X, Spertus JA, Masoudi FA, Krumholz HM, Jiang L. Design and rationale of the Cardiovascular Health and Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study: two randomised controlled trials of text messaging to improve secondary prevention for coronary heart disease and diabetes. BMJ Open 2017, 7: e018302. PMID: 29273661, PMCID: PMC5778311, DOI: 10.1136/bmjopen-2017-018302.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood PressureChinaCoronary DiseaseDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2ExerciseFemaleGlycated HemoglobinHumansLife StyleMaleMedication AdherenceMiddle AgedMotivationResearch DesignRisk FactorsSecondary PreventionSelf CareSingle-Blind MethodTelemedicineText MessagingYoung AdultConceptsSystolic blood pressureBody mass indexTrials of textProportion of patientsMedication adherencePhysical activitySecondary outcomesPrimary outcomeSmoking cessationCardiovascular healthMellitus StudySecondary coronary heart disease preventionCoronary heart disease preventionLow-density lipoprotein cholesterolUsual scientific forumsBlood pressure controlRisk factor managementHeart disease preventionCoronary heart diseaseMobile health interventionsInstitutional review boardUniversity Institutional Review BoardBehavioral skills modelText messagingBehavioral change techniquesHospital Performance on Percutaneous Coronary Intervention Process and Outcomes Measures
Chui PW, Parzynski CS, Nallamothu BK, Masoudi FA, Krumholz HM, Curtis JP. Hospital Performance on Percutaneous Coronary Intervention Process and Outcomes Measures. Journal Of The American Heart Association 2017, 6: e004276. PMID: 28446493, PMCID: PMC5524055, DOI: 10.1161/jaha.116.004276.Peer-Reviewed Original ResearchMeSH KeywordsCardiac RehabilitationCoronary DiseaseCross-Sectional StudiesHealthcare DisparitiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMedicarePatient DischargePatient ReadmissionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsProcess Assessment, Health CareQuality ImprovementQuality Indicators, Health CareReferral and ConsultationRegistriesRisk FactorsTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesConceptsProcess measuresReadmission ratesOutcome measuresNational Cardiovascular Data Registry CathPCI RegistryHospital performancePercutaneous coronary interventionSpecific process measuresRisk-standardized mortalityPCI patientsCathPCI RegistryCoronary interventionHospital variationOutcome ratesHospital qualityPhysician ConsortiumMortalitySmall percentageWeak correlationAssociationIntervention processPatients
2015
The Variation in Recovery
Spatz ES, Curry LA, Masoudi FA, Zhou S, Strait KM, Gross CP, Curtis JP, Lansky AJ, Soares Barreto-Filho JA, Lampropulos JF, Bueno H, Chaudhry SI, D'Onofrio G, Safdar B, Dreyer RP, Murugiah K, Spertus JA, Krumholz HM. The Variation in Recovery. Circulation 2015, 132: 1710-1718. PMID: 26350057, PMCID: PMC4858327, DOI: 10.1161/circulationaha.115.016502.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAlgorithmsAortic DissectionClassificationCoronary DiseaseDiagnostic Techniques, CardiovascularFemaleHumansMaleMedical RecordsMiddle AgedMyocardial InfarctionMyocardiumOxygen ConsumptionPhenotypePlaque, AtheroscleroticProspective StudiesReproducibility of ResultsRisk FactorsSex FactorsTreatment OutcomeYoung AdultConceptsAcute myocardial infarctionCoronary artery diseaseArtery diseaseClinical phenotypeNonobstructive coronary artery diseaseYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseYoung womenType 2 acute myocardial infarctionBiological disease mechanismsSubset of patientsThird universal definitionUnique clinical phenotypeCulprit lesionClinical characteristicsMyocardial infarctionTherapeutic efficacyUniversal definitionStudy participantsPatientsSupply-demand mismatchYoung adultsDisease mechanismsPatient studiesCurrent classification schemes
2013
Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis
Silverman MG, Blaha MJ, Krumholz HM, Budoff MJ, Blankstein R, Sibley CT, Agatston A, Blumenthal RS, Nasir K. Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis. European Heart Journal 2013, 35: 2232-2241. PMID: 24366919, PMCID: PMC4150068, DOI: 10.1093/eurheartj/eht508.Peer-Reviewed Original ResearchConceptsCoronary artery calciumCoronary heart disease eventsRisk factor burdenHeart disease eventsMulti-Ethnic StudyCAC 0Artery calciumRF burdenEvent ratesDisease eventsAbsence of CACDistribution of CACTraditional risk factor burdenCHD event ratesElevated event rateHigh CAC burdenFramingham risk scoreLow HDL cholesterolLow event ratesCAC burdenCHD eventsCAC scoreHDL cholesterolLDL cholesterolCigarette smoking
2011
Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention
Curtis JP, Rathore SS, Wang Y, Chen J, Nallamothu BK, Krumholz HM. Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention. Circulation Cardiovascular Quality And Outcomes 2011, 5: 21-30. PMID: 22147887, PMCID: PMC3801197, DOI: 10.1161/circoutcomes.110.960385.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionIntra-aortic balloon pumpPercutaneous coronary interventionHospital quartilesHospital mortalityIABP useCoronary interventionBalloon pumpHospital characteristicsST-segment elevation myocardial infarctionDepressed left ventricular functionHigh-risk PCI patientsSegment elevation myocardial infarctionElevation myocardial infarctionLeft ventricular functionHierarchical logistic regression modelsLogistic regression modelsIABP usageCardiogenic shockPCI patientsCathPCI RegistryHemodynamic supportVentricular functionHospital variationMultivariable analysis
2010
Meta-analysis: effects of percutaneous coronary intervention versus medical therapy on angina relief.
Wijeysundera HC, Nallamothu BK, Krumholz HM, Tu JV, Ko DT. Meta-analysis: effects of percutaneous coronary intervention versus medical therapy on angina relief. Annals Of Internal Medicine 2010, 152: 370-9. PMID: 20231568, DOI: 10.7326/0003-4819-152-6-201003160-00007.Peer-Reviewed Original ResearchMeSH KeywordsAngina PectorisAngioplasty, Balloon, CoronaryCoronary DiseaseDrug-Eluting StentsHumansMyocardial InfarctionRegression AnalysisConceptsPercutaneous coronary interventionStable coronary artery diseaseEvidence-based medicationsCoronary artery diseaseMedical therapyAngina reliefCoronary interventionArtery diseaseIndependent reviewersTrials of PCIIncremental benefitRecent myocardial infarctionInclusion of patientsEvidence-based therapiesStudy-level dataDrug-eluting stentsRandom-effects modelMeta-regression analysisLong-term usePatient characteristicsCochrane LibraryContemporary trialsLanguage restrictionsMyocardial infarctionRecent trials
2009
All-Cause Readmission and Repeat Revascularization After Percutaneous Coronary Intervention in a Cohort of Medicare Patients
Curtis JP, Schreiner G, Wang Y, Chen J, Spertus JA, Rumsfeld JS, Brindis RG, Krumholz HM. All-Cause Readmission and Repeat Revascularization After Percutaneous Coronary Intervention in a Cohort of Medicare Patients. Journal Of The American College Of Cardiology 2009, 54: 903-907. PMID: 19712799, DOI: 10.1016/j.jacc.2009.04.076.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionReadmission ratesRevascularization proceduresCause readmissionCoronary interventionPCI proceduresMortality rateIndex percutaneous coronary interventionAcute myocardial infarction patientsCause readmission rateIndex PCI procedureMedian readmission rateDays of dischargeRepeat revascularization proceduresMyocardial infarction patientsNon-AMI patientsPCI patientsRepeat revascularizationRevascularization ratesPrimary outcomeInfarction patientsSuch readmissionsMedicare patientsRetrospective analysisReadmission
2006
Comparison of Functional Status After Coronary Artery Bypass Grafting in Patients With and Without Diabetes Mellitus
Sahakyan K, Abramson JL, Krumholz HM, Vaccarino V. Comparison of Functional Status After Coronary Artery Bypass Grafting in Patients With and Without Diabetes Mellitus. The American Journal Of Cardiology 2006, 98: 619-623. PMID: 16923448, DOI: 10.1016/j.amjcard.2006.03.038.Peer-Reviewed Original ResearchConceptsPhysical Component Scale scoresCoronary artery bypassDiabetes mellitusPhysical functionMental healthArtery bypassScale scoreRisk of morbidityMental component scaleShort formHealth Survey dataDM statusFirst CABGCABG surgeryBaseline characteristicsConsecutive patientsFunctional recoveryFunctional statusPhysical functioningHealth SurveyCABGPatientsScore changeMellitusComponent scaleAHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update
Smith SC, Allen J, Blair SN, Bonow RO, Brass LM, Fonarow GC, Grundy SM, Hiratzka L, Jones D, Krumholz HM, Mosca L, Pasternak RC, Pearson T, Pfeffer MA, Taubert KA. AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update. Circulation 2006, 113: 2363-2372. PMID: 16702489, DOI: 10.1161/circulationaha.106.174516.Peer-Reviewed Original ResearchRegionalization of ST-Segment Elevation Acute Coronary Syndromes Care Putting a National Policy in Proper Perspective
Rathore SS, Epstein AJ, Nallamothu BK, Krumholz HM. Regionalization of ST-Segment Elevation Acute Coronary Syndromes Care Putting a National Policy in Proper Perspective. Journal Of The American College Of Cardiology 2006, 47: 1346-1349. PMID: 16580519, PMCID: PMC2789345, DOI: 10.1016/j.jacc.2005.11.053.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCISTEMI patientsFibrinolytic therapyPCI hospitalsST-segment elevation myocardial infarction (STEMI) careAcute coronary syndrome careHigh-volume PCI hospitalsHigh-risk STEMI patientsElevation Myocardial Infarction CareHigh-volume hospitalsLow-volume hospitalsPercutaneous coronary interventionMyocardial infarction careCardiac care facilitiesHealth care resourcesHealth care systemInitial hospitalPCI patientsCoronary interventionU.S. health care systemAverage patientSingle deathCare facilitiesPatients
2005
ACCF/ASNC Appropriateness Criteria for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging (SPECT MPI) A Report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group and the American Society of Nuclear Cardiology Endorsed by the American Heart Association
Brindis RG, Douglas PS, Hendel RC, Peterson ED, Wolk MJ, Allen JM, Patel MR, Raskin IE, Hendel RC, Bateman TM, Cerqueira MD, Gibbons RJ, Gillam LD, Gillespie JA, Hendel RC, Iskandrian AE, Jerome SD, Krumholz HM, Messer JV, Spertus JA, Stowers SA. ACCF/ASNC Appropriateness Criteria for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging (SPECT MPI) A Report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group and the American Society of Nuclear Cardiology Endorsed by the American Heart Association. Journal Of The American College Of Cardiology 2005, 46: 1587-1605. PMID: 16226194, DOI: 10.1016/j.jacc.2005.08.029.Peer-Reviewed Original ResearchConceptsTomography myocardial perfusion imagingMyocardial perfusion imagingSingle photon emissionAmerican CollegePerfusion imagingClinical practice guidelinesAmerican Heart AssociationAmerican SocietyReasonable approachNuclear cardiologyPhysician decision makingHealth services researchersHeart AssociationAppropriateness CriteriaAppropriateness reviewClinical indicationsPractice guidelinesCardiology FoundationClinical scenariosWorking GroupCardiovascular imagingNuclear cardiologistsReimbursement policiesScientific evidenceServices researchersRegionalization of Care for Acute Coronary Syndromes: More Evidence Is Needed
Rathore SS, Epstein AJ, Volpp KG, Krumholz HM. Regionalization of Care for Acute Coronary Syndromes: More Evidence Is Needed. JAMA 2005, 293: 1383-1387. PMID: 15769973, PMCID: PMC2790270, DOI: 10.1001/jama.293.11.1383.Peer-Reviewed Original Research
2004
Clinical trial of an educational intervention to achieve recommended cholesterol levels in patients with coronary artery disease
Lichtman JH, Amatruda J, Yaari S, Cheng S, Smith GL, Mattera JA, Roumanis SA, Wang Y, Radford MJ, Krumholz HM. Clinical trial of an educational intervention to achieve recommended cholesterol levels in patients with coronary artery disease. American Heart Journal 2004, 147: 522-528. PMID: 14999204, DOI: 10.1016/j.ahj.2003.06.003.Peer-Reviewed Original ResearchConceptsLDL cholesterol target levelsCholesterol target levelsProportion of patientsCoronary artery diseaseUsual care groupArtery diseaseLevels 1 yearCholesterol managementCare groupEducational interventionPatient knowledgeLow-density lipoprotein cholesterol (LDL-C) target levelsTarget levelCholesterol knowledgeUsual careClinical characteristicsSecondary outcomesPrimary outcomeCholesterol levelsClinical trialsIntervention groupPatientsHospitalizationDiseaseInterventionSocial Support as a Predictor of Participation in Cardiac Rehabilitation After Coronary Artery Bypass Graft Surgery
Husak L, Krumholz HM, Lin ZQ, Kasl SV, Mattera JA, Roumanis SA, Vaccarino V. Social Support as a Predictor of Participation in Cardiac Rehabilitation After Coronary Artery Bypass Graft Surgery. Journal Of Cardiopulmonary Rehabilitation And Prevention 2004, 24: 19-26. PMID: 14758099, DOI: 10.1097/00008483-200401000-00005.Peer-Reviewed Original ResearchMeSH KeywordsAgedConnecticutCoronary Artery BypassCoronary DiseaseFemaleFollow-Up StudiesHumansMaleMarital StatusMiddle AgedMultivariate AnalysisPredictive Value of TestsPrevalenceQuality of LifeReferral and ConsultationRisk FactorsSickness Impact ProfileSocial SupportStroke VolumeSurvival AnalysisTreatment OutcomeConceptsCoronary artery bypass graftCardiovascular disease risk factorsDisease risk factorsCardiac rehabilitationRisk factorsCoronary artery bypass graft surgeryArtery bypass graft surgerySocial supportBypass graft surgeryArtery bypass graftBetter physical functionCardiac rehabilitation participationQuality of lifeLow social supportMain predictive variableComorbidity burdenHospital complicationsGraft surgerySocial Support InventoryIndependent predictorsBypass graftPhysical functionPredictors of participationUnadjusted analysesMedical historyHospital Coronary Artery Bypass Graft Surgery Volume and Patient Mortality, 1998–2000
Rathore SS, Epstein AJ, Volpp KG, Krumholz HM. Hospital Coronary Artery Bypass Graft Surgery Volume and Patient Mortality, 1998–2000. Annals Of Surgery 2004, 239: 110-117. PMID: 14685108, PMCID: PMC1356200, DOI: 10.1097/01.sla.0000103066.22732.b8.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAnalysis of VarianceCause of DeathCoronary Artery BypassCoronary DiseaseFemaleHospital MortalityHumansIncidenceMaleMiddle AgedOdds RatioOutcome Assessment, Health CareProbabilityRegistriesRetrospective StudiesRisk AssessmentSampling StudiesSex DistributionTotal Quality ManagementUnited StatesConceptsLow-volume hospitalsMedium-volume hospitalsHigh-volume hospitalsSurgery volumeMortality riskMortality rateNational Inpatient Sample databaseRisk-standardized mortality ratesHospital CABG volumeHospital mortality rateRisk of mortalityLower mortality riskHealth care purchasersHospital mortalityMultivariable adjustmentVolume hospitalsBorderline significanceCABG volumeRetrospective analysisVolume groupMortality differencesPatientsHospitalLeapfrog GroupReliable marker
2003
Risk factors and secondary prevention in women with heart disease.
Rathore SS, Krumholz HM. Risk factors and secondary prevention in women with heart disease. Annals Of Internal Medicine 2003, 139: 954; author reply 954-5. PMID: 14644900, DOI: 10.7326/0003-4819-139-11-200312020-00016.Peer-Reviewed Original Research