2015
Effectiveness of implantable cardioverter-defibrillators in survivors of inhospital cardiac arrest
Chan PS, Krumholz HM, Spertus JA, Curtis LH, Li Y, Hammill BG, Nallamothu BK, investigators A. Effectiveness of implantable cardioverter-defibrillators in survivors of inhospital cardiac arrest. American Heart Journal 2015, 169: 870-878.e1. PMID: 26027626, PMCID: PMC4451609, DOI: 10.1016/j.ahj.2015.02.016.Peer-Reviewed Original ResearchConceptsInhospital cardiac arrestLong-term mortalityHospital cardiac arrestCardiac arrestICD treatmentLower long-term mortalityImplantable cardioverter-defibrillator therapyHigh illness acuityHigher unadjusted mortalityICD-treated patientsCardiac Arrest RegistryCardioverter-defibrillator therapyPulseless ventricular tachycardiaHigh-risk populationComparative effectiveness studiesLong-term survivalPropensity score analysisLower mortality rateArrest etiologyEligible survivorsICD trialsHospital deathICD therapyIndex hospitalizationUntreated patients
2014
Trends in Hospitalizations Among Medicare Survivors of Aortic Valve Replacement in the United States From 1999 to 2010
Murugiah K, Wang Y, Dodson JA, Nuti SV, Dharmarajan K, Ranasinghe I, Cooper Z, Krumholz HM. Trends in Hospitalizations Among Medicare Survivors of Aortic Valve Replacement in the United States From 1999 to 2010. The Annals Of Thoracic Surgery 2014, 99: 509-517. PMID: 25527425, PMCID: PMC4454375, DOI: 10.1016/j.athoracsur.2014.08.045.Peer-Reviewed Original ResearchConceptsAortic valve replacementValve replacementHospitalization ratesAnnual Medicare paymentsPrincipal diagnosisOne-year hospitalization rateCommon principal diagnosisRisk of hospitalizationMean lengthGeneral Medicare populationMedicare paymentsPostoperative complicationsHeart failureBlack patientsMedicare patientsHospitalizationMedicare populationMedicare beneficiariesMortality ratePatientsStayCumulative daysCumulative lengthCertain subgroupsSurvivorsReadmission Rates and Long-Term Hospital Costs Among Survivors of an In-Hospital Cardiac Arrest
Chan PS, Nallamothu BK, Krumholz HM, Curtis LH, Li Y, Hammill BG, Spertus JA. Readmission Rates and Long-Term Hospital Costs Among Survivors of an In-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2014, 7: 889-895. PMID: 25351479, PMCID: PMC4241155, DOI: 10.1161/circoutcomes.114.000925.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestInpatient costsMean inpatient costsLarge national registryInpatient resource useNeurological statusReadmission patternsHospital dispositionPatient demographicsReadmission ratesMean ageInpatient useNational registryYounger ageReadmissionArrestAgeYearsDaysPatientsRegistryResource useSurvivors
2012
A Validated Prediction Tool for Initial Survivors of In-Hospital Cardiac Arrest
Chan PS, Spertus JA, Krumholz HM, Berg RA, Li Y, Sasson C, Nallamothu BK, Investigators F. A Validated Prediction Tool for Initial Survivors of In-Hospital Cardiac Arrest. JAMA Internal Medicine 2012, 172: 947-953. PMID: 22641228, PMCID: PMC3517176, DOI: 10.1001/archinternmed.2012.2050.Peer-Reviewed Original ResearchConceptsFavorable neurological survivalHospital cardiac arrestNeurological survivalCardiac arrestNeurological statusDerivation cohortValidation cohortInitial cardiac arrest rhythmIn-Hospital Cardiac ArrestBaseline neurological statusFavorable neurological statusGuidelines-Resuscitation registryCardiac arrest rhythmSevere neurological deficitsPulseless ventricular tachycardiaMultivariate logistic regressionSimple prediction toolRenal insufficiencyArrest rhythmNeurological deficitsHepatic insufficiencyMechanical ventilationMalignant diseaseVentricular tachycardiaInitial survivorsPhysical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry
Dodson JA, Arnold SV, Reid KJ, Gill TM, Rich MW, Masoudi FA, Spertus JA, Krumholz HM, Alexander KP. Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry. American Heart Journal 2012, 163: 790-796. PMID: 22607856, PMCID: PMC3359897, DOI: 10.1016/j.ahj.2012.02.024.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedAngioplasty, Balloon, CoronaryAttitude to HealthCardiac CatheterizationCoronary AngiographyDepressionElectrocardiographyFemaleFollow-Up StudiesHealth SurveysHumansIncidenceIndependent LivingMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPhysical FitnessPoisson DistributionPredictive Value of TestsQuality of LifeRegistriesRisk AssessmentSickness Impact ProfileSurveys and QuestionnairesSurvivorsTime FactorsTranslational Research, BiomedicalConceptsAcute myocardial infarctionPhysical function declineFunction declinePhysical functionMyocardial infarctionHealth statusEuroQol-5DUninsured statusTime of AMIShort Form-12 Physical Component ScoreIndependence lossEnd-stage renal diseasePost-acute myocardial infarctionCardiac rehabilitation referralPhysical component scorePatients' health statusQuality of lifePoisson regression modelsTRIUMPH registryRehabilitation referralRenal diseaseNonwhite raceFemale sexRisk factorsUnmarried status
2009
Increased Mortality among Survivors of Myocardial Infarction with Kidney Dysfunction: the Contribution of Gaps in the use of Guideline-Based Therapies
Peterson PN, Ambardekar AV, Jones PG, Krumholz HM, Schelbert E, Spertus JA, Rumsfeld JS, Masoudi FA. Increased Mortality among Survivors of Myocardial Infarction with Kidney Dysfunction: the Contribution of Gaps in the use of Guideline-Based Therapies. BMC Cardiovascular Disorders 2009, 9: 29. PMID: 19586550, PMCID: PMC2716301, DOI: 10.1186/1471-2261-9-29.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedFemaleGlomerular Filtration RateHumansKaplan-Meier EstimateKidney DiseasesMaleMiddle AgedMyocardial InfarctionPractice Guidelines as TopicProportional Hazards ModelsProspective StudiesRegistriesRisk AssessmentSeverity of Illness IndexSurvivorsTime FactorsTreatment OutcomeUnited StatesConceptsGlomerular filtration rateAcute myocardial infarctionGuideline-based medical therapyGuideline-based therapyMedical therapyKidney dysfunctionMyocardial infarctionUse of guidelinesEligible patientsRenal dysfunctionHazard ratioCox regressionPathophysiological abnormalitiesClinical variablesKidney diseaseFiltration rateNovel therapiesUS CentersHigh mortalityPatientsTherapyFurther adjustmentMortalityDysfunctionTreatment factors
2007
Predictors of weight change in overweight patients with myocardial infarction
Fadl YY, Krumholz HM, Kosiborod M, Masoudi FA, Peterson PN, Reid KJ, Weintraub WS, Buchanan DM, Spertus JA. Predictors of weight change in overweight patients with myocardial infarction. American Heart Journal 2007, 154: 711-717. PMID: 17892997, DOI: 10.1016/j.ahj.2007.06.006.Peer-Reviewed Original ResearchConceptsPost-MI patientsMyocardial infarctionOverweight patientsWeight changeWeight lossDepression 1 monthMean weight changePercent weight changeMultivariable linear regressionBaseline obesityOverweight survivorsMorbid obesityObese patientsProspective cohortMultivariable analysisIndependent correlatesWeight managementLifestyle characteristicsPatientsMean increasePREMIER studyHealth insuranceMonthsOverweightInfarction
2003
Long‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project
Foody JM, Wang Y, Kiefe CI, Ellerbeck EF, Gold J, Radford MJ, Krumholz HM. Long‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project. Journal Of The American Geriatrics Society 2003, 51: 930-936. PMID: 12834512, DOI: 10.1046/j.1365-2389.2003.51305.x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTotal serum cholesterolElevated total serum cholesterolCoronary artery diseaseCause mortalityTotal cholesterolSerum cholesterolElderly survivorsPrognostic importanceMyocardial infarctionCholesterol levelsLong-term prognostic importanceRetrospective medical record reviewAdjusted hazard ratioMedical record reviewLower total cholesterolStudy inclusion criteriaYear of dischargePrimary endpointOlder patientsArtery diseaseHazard ratioRecord reviewAcute careLipid subfractions
2001
Predicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project
Krumholz H, Chen J, Chen Y, Wang Y, Radford M. Predicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project. Journal Of The American College Of Cardiology 2001, 38: 453-459. PMID: 11499737, DOI: 10.1016/s0735-1097(01)01395-x.Peer-Reviewed Original ResearchConceptsOne-year mortalityAcute myocardial infarctionMyocardial infarctionPeripheral vascular diseaseCohort of patientsBody mass indexCooperative Cardiovascular ProjectRisk of mortalityDeath one yearPopulation-based sampleSimple risk modelRenal dysfunctionVentricular dysfunctionElderly patientsOlder patientsUrinary incontinenceHeart failureMass indexAcute carePrognostic importanceMean ageVascular diseaseMedical recordsRisk groupsOlder survivors