2013
Patterns of Change in Nesiritide Use in Patients With Heart Failure How Hospitals React to New Information
Partovian C, Li SX, Xu X, Lin H, Strait KM, Hwa J, Krumholz HM. Patterns of Change in Nesiritide Use in Patients With Heart Failure How Hospitals React to New Information. JACC Heart Failure 2013, 1: 318-324. PMID: 24621935, PMCID: PMC5322944, DOI: 10.1016/j.jchf.2013.04.005.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Drug Reaction Reporting SystemsDrug UtilizationHeart FailureHospitalizationHospitalsHumansNatriuretic AgentsNatriuretic Peptide, BrainConceptsHeart failureNesiritide useHospital characteristicsHospital groupDecompensated heart failureProportion of hospitalizationsPatterns of changeMultivariate regression analysisPatient characteristicsEarly reliefHospital patternsHospitalTeaching statusPremier databaseMedical evidenceHospitalizationPatientsRegression analysisSafety concernsLow usersUse ratesGroupFailureFurther researchDyspnea
2009
Pooled Analysis of Rofecoxib Placebo-Controlled Clinical Trial Data: Lessons for Postmarket Pharmaceutical Safety Surveillance
Ross JS, Madigan D, Hill KP, Egilman DS, Wang Y, Krumholz HM. Pooled Analysis of Rofecoxib Placebo-Controlled Clinical Trial Data: Lessons for Postmarket Pharmaceutical Safety Surveillance. JAMA Internal Medicine 2009, 169: 1976-1985. PMID: 19933959, PMCID: PMC2830805, DOI: 10.1001/archinternmed.2009.394.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Drug Reaction Reporting SystemsCardiovascular SystemCyclooxygenase 2 InhibitorsDrug IndustryHumansIncidenceLactonesMyocardial InfarctionRandomized Controlled Trials as TopicRisk AssessmentSafety-Based Drug WithdrawalsSulfonesTime FactorsUnited StatesUnited States Food and Drug AdministrationConceptsPlacebo-controlled trialVoluntary market withdrawalAdverse eventsCardiovascular riskThromboembolic adverse eventsMain outcome measurementsClinical trial dataRofecoxib groupOutcome measurementsTrial dataPlaceboTrial durationSafety surveillanceTrialsMarket withdrawalDeathRiskP-valueSurveillance effortsSubjectsWithdrawalRofecoxibYearsIncidenceDose