2020
Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults
Ding Q, Spatz ES, Lipska KJ, Lin H, Spertus JA, Dreyer RP, Whittemore R, Funk M, Bueno H, Krumholz HM. Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults. Heart 2020, 107: 657-666. PMID: 33082173, PMCID: PMC8005796, DOI: 10.1136/heartjnl-2020-317101.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth statusDischarge diagnosisPharmacological treatmentMyocardial infarctionShort-term health statusYoung AMI Patients (VIRGO) studyDisease-specific health statusYoung adultsQuality of lifeHospital complicationsHospital mortalityMedication initiationBaseline characteristicsClinical outcomesDiabetesPatientsDiagnosisPatient studiesMonthsComplicationsInfarctionSignificant differencesOutcomesMortalitySex Differences in Symptom Phenotypes Among Patients With Acute Myocardial Infarction
Brush JE, Krumholz HM, Greene EJ, Dreyer RP. Sex Differences in Symptom Phenotypes Among Patients With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2020, 13: e005948. PMID: 32063049, PMCID: PMC7041412, DOI: 10.1161/circoutcomes.119.005948.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBiological Variation, IndividualFemaleHealth Status DisparitiesHumansInterviews as TopicMaleMiddle AgedMyocardial InfarctionPatient AdmissionPhenotypePredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsSex FactorsSpainSymptom AssessmentUnited StatesYoung AdultConceptsAcute myocardial infarctionMyocardial infarctionMedical recordsYoung womenDiagnosis of AMIObservational cohort studyMedical record abstractionSymptom phenotypeDiagnostic processAnalysis of symptomsVIRGO StudyCohort studyRecord abstractionIndividual patientsClinician's abilityDiagnosis rateStandardized interviewPhenotype subgroupsSymptomsSimilar findingsYoung adultsWomenMenInfarctionPatients
2019
Association of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study
Ding Q, Funk M, Spatz ES, Whittemore R, Lin H, Lipska KJ, Dreyer RP, Spertus JA, Krumholz HM. Association of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study. Journal Of The American Heart Association 2019, 8: e010988. PMID: 31441351, PMCID: PMC6755841, DOI: 10.1161/jaha.118.010988.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsDiabetes MellitusFemaleHealth StatusHealth Status IndicatorsHumansMaleMental HealthMiddle AgedMyocardial InfarctionPatient Reported Outcome MeasuresPredictive Value of TestsPrevalencePrognosisQuality of LifeRecovery of FunctionRisk AssessmentRisk FactorsSex FactorsSpainTime FactorsUnited StatesYoung AdultConceptsAcute myocardial infarctionEuroQol visual analogue scaleSeattle Angina QuestionnaireDiabetes mellitusForm Health SurveyHealth status outcomesHealth statusVIRGO StudyAnalog scaleMyocardial infarctionHealth SurveyStatus outcomesYoung adultsSAQ angina frequencyCardiovascular risk factorsHealth status scoresRisk of mortalityWorse health statusPoor health statusQuality of lifeWorse anginaAngina QuestionnaireClinical characteristicsHealthcare useStatus score
2018
Sex Differences in Omega‐3 and ‐6 Fatty Acids and Health Status Among Young Adults With Acute Myocardial Infarction: Results From the VIRGO Study
Lu Y, Ding Q, Xu X, Spatz ES, Dreyer RP, D'Onofrio G, Caulfield M, Nasir K, Spertus JA, Krumholz HM. Sex Differences in Omega‐3 and ‐6 Fatty Acids and Health Status Among Young Adults With Acute Myocardial Infarction: Results From the VIRGO Study. Journal Of The American Heart Association 2018, 7: e008189. PMID: 29848494, PMCID: PMC6015388, DOI: 10.1161/jaha.117.008189.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status scoresArachidonic acidVIRGO StudyStatus scoreMyocardial infarctionHealth statusPoorer health status outcomesYoung menPatient-reported health statusYoung womenOmega-3 fatty acidsSex differencesPatient-reported outcomesFatty acidsHealth status outcomesCardiovascular outcomesClinical characteristicsAdjusted analysisAMI patientsRisk factorsUS adultsStatus outcomesOmega-3Women 1Sex Differences in Timeliness of Reperfusion in Young Patients With ST‐Segment–Elevation Myocardial Infarction by Initial Electrocardiographic Characteristics
Gupta A, Barrabes JA, Strait K, Bueno H, Porta‐Sánchez A, Acosta‐Vélez J, Lidón R, Spatz E, Geda M, Dreyer RP, Lorenze N, Lichtman J, D'Onofrio G, Krumholz HM. Sex Differences in Timeliness of Reperfusion in Young Patients With ST‐Segment–Elevation Myocardial Infarction by Initial Electrocardiographic Characteristics. Journal Of The American Heart Association 2018, 7: e007021. PMID: 29514807, PMCID: PMC5907538, DOI: 10.1161/jaha.117.007021.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetElectrocardiographyFemaleHealthcare DisparitiesHumansMaleMiddle AgedMyocardial ReperfusionPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsSex FactorsSpainST Elevation Myocardial InfarctionTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesYoung AdultConceptsST-segment elevation myocardial infarctionElectrocardiographic characteristicsMyocardial infarctionReperfusion delayYounger patientsVentricular hypertrophyST elevationPrehospital ECGLateral leadsMultivariable logistic regression modelTimeliness of reperfusionVoltage criteriaElevation myocardial infarctionLeft ventricular hypertrophyAcute myocardial infarctionYears of ageLogistic regression modelsSex differencesClinical characteristicsCohort studyElectrocardiographic correlatesMultivariable analysisFemale sexSpanish hospitalsReperfusion guidelines
2017
Comparison of Electrocardiographic Characteristics in Men Versus Women ≤ 55 Years With Acute Myocardial Infarction (a Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients Substudy)
Barrabés JA, Gupta A, Porta-Sánchez A, Strait KM, Acosta-Vélez JG, D'Onofrio G, Lidón RM, Geda M, Dreyer RP, Lorenze NP, Lichtman JH, Spertus JA, Bueno H, Krumholz HM. Comparison of Electrocardiographic Characteristics in Men Versus Women ≤ 55 Years With Acute Myocardial Infarction (a Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients Substudy). The American Journal Of Cardiology 2017, 120: 1727-1733. PMID: 28865896, DOI: 10.1016/j.amjcard.2017.07.106.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionST-segment depressionElectrocardiographic presentationMyocardial infarctionQ wavesAnterior ST segment depressionST-segment elevation myocardial infarction diagnosisOutcome of AMIYoung AMI patientsMen Versus WomenST-segment elevationLonger QTc intervalsIntraventricular conduction disturbancesCentral core labNegative T wavesAbnormal Q wavesGender-related differencesBaseline characteristicsContemporary registryAnterior leadsMyocardial infarction diagnosisYounger patientsQTc intervalAMI patientsWorse prognosis
2016
Gender differences in physical activity following acute myocardial infarction in adults: A prospective, observational study
Minges KE, Strait KM, Owen N, Dunstan DW, Camhi SM, Lichtman J, Geda M, Dreyer RP, Bueno H, Beltrame JF, Curtis JP, Krumholz HM. Gender differences in physical activity following acute myocardial infarction in adults: A prospective, observational study. European Journal Of Preventive Cardiology 2016, 24: 192-203. PMID: 27885060, DOI: 10.1177/2047487316679905.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAustraliaCardiac RehabilitationChi-Square DistributionExerciseExercise TherapyFemaleHealth BehaviorHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedMyocardial InfarctionOdds RatioPatient ComplianceProspective StudiesRisk FactorsSex FactorsSpainTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsAcute myocardial infarctionPost-acute myocardial infarctionMyocardial infarctionPhysical activityRegular physical activity participationYoung AMI Patients (VIRGO) studyPhysical activity recommendationsAmerican Heart AssociationPhysical activity trajectoriesNon-white raceMyocardial infarction recoveryPhysical activity participationGender differencesHospital dischargeHeart AssociationLifestyle behaviorsActivity recommendationsObservational studyInfarctionAustralian hospitalsTargeted interventionsOne monthPatientsTime pointsLonger durationSex Differences in Financial Barriers and the Relationship to Recovery After Acute Myocardial Infarction
Beckman AL, Bucholz EM, Zhang W, Xu X, Dreyer RP, Strait KM, Spertus JA, Krumholz HM, Spatz ES. Sex Differences in Financial Barriers and the Relationship to Recovery After Acute Myocardial Infarction. Journal Of The American Heart Association 2016, 5: e003923. PMID: 27742618, PMCID: PMC5121496, DOI: 10.1161/jaha.116.003923.Peer-Reviewed Original ResearchMeSH KeywordsAdultAftercareDepressionDrug CostsFemaleHealth Services AccessibilityHumansIncomeLinear ModelsMaleMedication AdherenceMiddle AgedMultivariate AnalysisMyocardial InfarctionPatient Health QuestionnaireProspective StudiesRecovery of FunctionSex FactorsSocioeconomic FactorsSpainUnited StatesConceptsAcute myocardial infarctionMyocardial infarctionFinancial barriersHealth status 12 monthsYoung adultsPost-AMI outcomesYear post-AMIYoung AMI patientsMultivariable linear regression modelsGreater depressive symptomatologyMental functional statusSex differencesClinical characteristicsYounger patientsAMI patientsPost-AMIFunctional statusWorse outcomesBaseline healthPsychosocial statusOutcomes 1Depressive symptomatologyPatientsMore womenHealth careSexual Activity and Function in the Year After an Acute Myocardial Infarction Among Younger Women and Men in the United States and Spain
Lindau ST, Abramsohn E, Bueno H, D’Onofrio G, Lichtman JH, Lorenze NP, Sanghani RM, Spatz ES, Spertus JA, Strait KM, Wroblewski K, Zhou S, Krumholz HM. Sexual Activity and Function in the Year After an Acute Myocardial Infarction Among Younger Women and Men in the United States and Spain. JAMA Cardiology 2016, 1: 754-764. PMID: 27579897, PMCID: PMC5459405, DOI: 10.1001/jamacardio.2016.2362.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionSexual function problemsSexual activityMyocardial infarctionYoung AMI Patients (VIRGO) studyYoung womenSexual problemsModifiable risk factorsLogistic regression analysisMultinomial logistic regression analysisPrevalent sexual problemPhysician counselingMedian ageMost young adultsSexual functionRisk factorsSpanish hospitalsMAIN OUTCOMEErectile difficultiesFirst monthYoung adultsTime pointsWomenMore womenPatient studiesEditor’s Choice-Sex differences in young patients with acute myocardial infarction: A VIRGO study analysis
Bucholz EM, Strait KM, Dreyer RP, Lindau ST, D’Onofrio G, Geda M, Spatz ES, Beltrame JF, Lichtman JH, Lorenze NP, Bueno H, Krumholz HM. Editor’s Choice-Sex differences in young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2016, 6: 610-622. PMID: 27485141, PMCID: PMC5459677, DOI: 10.1177/2048872616661847.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionYoung womenTime of AMIST-segment elevation myocardial infarctionHigh clinical risk scoreSegment elevation myocardial infarctionChronic obstructive pulmonary diseaseYoung AMI patientsCardiovascular risk factorsClinical risk scorePre-hospital delayProspective cohort studyCongestive heart failureElevation myocardial infarctionObstructive pulmonary diseaseHigh-risk populationYoung menMental health statusElectrocardiogram findingsMorbid obesityCardiovascular riskCohort studyRenal failureYounger patients
2015
Sex Differences in Cardiac Risk Factors, Perceived Risk, and Health Care Provider Discussion of Risk and Risk Modification Among Young Patients With Acute Myocardial Infarction The VIRGO Study
Leifheit-Limson EC, D’Onofrio G, Daneshvar M, Geda M, Bueno H, Spertus JA, Krumholz HM, Lichtman JH. Sex Differences in Cardiac Risk Factors, Perceived Risk, and Health Care Provider Discussion of Risk and Risk Modification Among Young Patients With Acute Myocardial Infarction The VIRGO Study. Journal Of The American College Of Cardiology 2015, 66: 1949-1957. PMID: 26515996, PMCID: PMC4628727, DOI: 10.1016/j.jacc.2015.08.859.Peer-Reviewed Original ResearchConceptsCardiac risk factorsAcute myocardial infarctionHealth care provider discussionsRisk modificationRisk factorsHeart diseaseHealth care providersProvider discussionsVIRGO StudyYounger patientsMyocardial infarctionCare providersSignificant cardiac risk factorsYoung AMI patientsPatients age 18Heart disease riskRisk factor prevalenceSelf-perceived riskModified Poisson regressionSex differencesFactor prevalenceAMI patientsCardiac riskSpanish hospitalsProvider feedbackInsurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction
Chen SI, Wang Y, Dreyer R, Strait KM, Spatz ES, Xu X, Smolderen KG, Desai NR, Lorenze NP, Lichtman JH, Spertus JA, D'Onofrio G, Bueno H, Masoudi FA, Krumholz HM. Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction. The American Journal Of Cardiology 2015, 116: 1827-1832. PMID: 26541907, PMCID: PMC5323057, DOI: 10.1016/j.amjcard.2015.09.018.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrehospital delayInsurance statusMyocardial infarctionSpanish patientsGender differencesHealth care systemUS patientsProspective studyUS cohortUS womenPatientsUniversal insuranceCare systemWomenSignificant gender differencesInfarctionMenInsurance groupsHoursStatusAssociationLarge proportionDifferencesCohortDepressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study
Smolderen KG, Strait KM, Dreyer RP, D'Onofrio G, Zhou S, Lichtman JH, Geda M, Bueno H, Beltrame J, Safdar B, Krumholz HM, Spertus JA. Depressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study. Journal Of The American Heart Association 2015, 4: e001424. PMID: 25836055, PMCID: PMC4579927, DOI: 10.1161/jaha.114.001424.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDepressive symptomsLifetime historyMyocardial infarctionRisk factorsYoung acute myocardial infarctionYoung AMI Patients (VIRGO) studyMore cardiovascular risk factorsYoung womenCardiovascular risk factorsTime of admissionAdverse medical outcomesMore depressive symptomsLow socioeconomic profileAMI severityVIRGO StudyCardiovascular riskChart abstractionYounger patientsClinical profileRelevant sex differencesPatient profilesAMI admissionsMedical outcomesPatientsGender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis
Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior coronary artery diseaseCoronary artery diseaseHealth statusMyocardial infarctionYounger patientsArtery diseaseCoronary artery disease historyDisease-specific health statusAcute myocardial infarction patientsAggressive symptom controlCornerstone of careWorse physical functionBaseline health statusMedical record abstractionVisual analog scaleHealth status outcomesMyocardial infarction patientsDisease-specific measuresMean health scoresLogistic regression analysisQuality of lifeHealth status informationGender differencesSymptom control
2014
Sexual Activity and Counseling in the First Month After Acute Myocardial Infarction Among Younger Adults in the United States and Spain
Lindau ST, Abramsohn EM, Bueno H, D'Onofrio G, Lichtman JH, Lorenze NP, Mehta Sanghani R, Spatz ES, Spertus JA, Strait K, Wroblewski K, Zhou S, Krumholz HM. Sexual Activity and Counseling in the First Month After Acute Myocardial Infarction Among Younger Adults in the United States and Spain. Circulation 2014, 130: 2302-2309. PMID: 25512442, PMCID: PMC4322946, DOI: 10.1161/circulationaha.114.012709.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsCounselingFemaleHumansLongitudinal StudiesMaleMiddle AgedMyocardial InfarctionPhysician-Patient RelationsProspective StudiesRisk AssessmentSex FactorsSexual BehaviorSexual Dysfunction, PhysiologicalSexual Dysfunctions, PsychologicalSpainUnited StatesYoung AdultConceptsAcute myocardial infarctionSexual activityMyocardial infarctionPatient experienceYoung AMI Patients (VIRGO) studyBaseline sexual activityPhysicians counsel patientsRisk-adjusted analysisMen ages 18Sample of womenPhysician counselingCounsel patientsMedian ageSociety guidelinesFemale genderHeart rateSexual inactivityU.S. womenAge 18First monthPatientsYoung adultsPatient studiesCounselingWomen
2010
Opportunities to Improve Care for Patients With ST-Segment Elevation Myocardial Infarction: Focusing on How to Deliver the Care
Krumholz H. Opportunities to Improve Care for Patients With ST-Segment Elevation Myocardial Infarction: Focusing on How to Deliver the Care. Revista Española De Cardiología 2010, 63: 509-512. PMID: 20450842, DOI: 10.1016/s1885-5857(10)70110-9.Peer-Reviewed Original ResearchOportunidades para mejorar la asistencia de los pacientes con infarto de miocardio con elevación del segmento ST: enfoque sobre la prestación de la asistencia
Krumholz HM. Oportunidades para mejorar la asistencia de los pacientes con infarto de miocardio con elevación del segmento ST: enfoque sobre la prestación de la asistencia. Revista Española De Cardiología 2010, 63: 509-512. DOI: 10.1016/s0300-8932(10)70110-x.Peer-Reviewed Original ResearchThe relationship between systolic blood pressure on admission and mortality in older patients with heart failure
Vidán MT, Bueno H, Wang Y, Schreiner G, Ross JS, Chen J, Krumholz HM. The relationship between systolic blood pressure on admission and mortality in older patients with heart failure. European Journal Of Heart Failure 2010, 12: 148-155. PMID: 20083624, PMCID: PMC2807767, DOI: 10.1093/eurjhf/hfp195.Peer-Reviewed Original ResearchConceptsAdmission systolic blood pressureSystolic blood pressureHeart failureBlood pressureOlder patientsNational Heart Failure ProjectHigher systolic blood pressureInitial systolic blood pressureHeart Failure ProjectMultivariable logistic regressionPrevious hypertensionSBP 90Ventricular dysfunctionClinical factorsIndependent associationOdds ratioMedicare patientsMortality ratePatientsMmHgLogistic regressionMortalityAdmissionSubgroupsInverse relationship