2020
Revascularization Practices and Outcomes in Patients With Multivessel Coronary Artery Disease Who Presented With Acute Myocardial Infarction and Cardiogenic Shock in the US, 2009-2018
Khera R, Secemsky EA, Wang Y, Desai NR, Krumholz HM, Maddox TM, Shunk KA, Virani SS, Bhatt DL, Curtis J, Yeh RW. Revascularization Practices and Outcomes in Patients With Multivessel Coronary Artery Disease Who Presented With Acute Myocardial Infarction and Cardiogenic Shock in the US, 2009-2018. JAMA Internal Medicine 2020, 180: 1317-1327. PMID: 32833024, PMCID: PMC9377424, DOI: 10.1001/jamainternmed.2020.3276.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCohort StudiesCoronary VesselsFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionPatient DischargePercutaneous Coronary InterventionRisk AssessmentRisk FactorsShock, CardiogenicST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionMultivessel percutaneous coronary interventionMultivessel coronary artery diseasePercutaneous coronary interventionAcute myocardial infarctionCoronary artery diseaseCulprit vessel percutaneous coronary interventionCardiogenic shockHospital mortalityArtery diseaseMyocardial infarctionCohort studyPrimary outcomeHospital variationPCI strategyMedicare beneficiariesUnderwent multivessel PCISignificant hospital variationElevation myocardial infarctionSubset of patientsHigh-risk populationRecent evidenceHospital complicationsPCI useRevascularization practice
2016
Underweight, Markers of Cachexia, and Mortality in Acute Myocardial Infarction: A Prospective Cohort Study of Elderly Medicare Beneficiaries
Bucholz EM, Krumholz HA, Krumholz HM. Underweight, Markers of Cachexia, and Mortality in Acute Myocardial Infarction: A Prospective Cohort Study of Elderly Medicare Beneficiaries. PLOS Medicine 2016, 13: e1001998. PMID: 27093615, PMCID: PMC4836735, DOI: 10.1371/journal.pmed.1001998.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overBody Mass IndexCachexiaComorbidityFemaleFrail ElderlyGeriatric AssessmentHospital MortalityHumansInsurance BenefitsKaplan-Meier EstimateMaleMedicareMyocardial InfarctionNutrition AssessmentNutritional StatusPrevalencePrognosisProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsThinnessTime FactorsUnited StatesConceptsLower body mass indexNormal weight patientsBody mass indexAcute myocardial infarctionUnderweight patientsWeight patientsSubset of patientsHigh riskFrailty measuresLaboratory markersMyocardial infarctionMedicare beneficiariesNutritional statusCox proportional hazards regressionUnderweight body mass indexMarkers of cachexiaLong-term mortalityProspective cohort studyCohort-based studyMeasures of frailtyProportional hazards regressionCooperative Cardiovascular ProjectElderly Medicare beneficiariesImportant risk factorSignificant chronic illness
2015
The Variation in Recovery
Spatz ES, Curry LA, Masoudi FA, Zhou S, Strait KM, Gross CP, Curtis JP, Lansky AJ, Soares Barreto-Filho JA, Lampropulos JF, Bueno H, Chaudhry SI, D'Onofrio G, Safdar B, Dreyer RP, Murugiah K, Spertus JA, Krumholz HM. The Variation in Recovery. Circulation 2015, 132: 1710-1718. PMID: 26350057, PMCID: PMC4858327, DOI: 10.1161/circulationaha.115.016502.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAlgorithmsAortic DissectionClassificationCoronary DiseaseDiagnostic Techniques, CardiovascularFemaleHumansMaleMedical RecordsMiddle AgedMyocardial InfarctionMyocardiumOxygen ConsumptionPhenotypePlaque, AtheroscleroticProspective StudiesReproducibility of ResultsRisk FactorsSex FactorsTreatment OutcomeYoung AdultConceptsAcute myocardial infarctionCoronary artery diseaseArtery diseaseClinical phenotypeNonobstructive coronary artery diseaseYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseYoung womenType 2 acute myocardial infarctionBiological disease mechanismsSubset of patientsThird universal definitionUnique clinical phenotypeCulprit lesionClinical characteristicsMyocardial infarctionTherapeutic efficacyUniversal definitionStudy participantsPatientsSupply-demand mismatchYoung adultsDisease mechanismsPatient studiesCurrent classification schemes
2011
Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH)
Arnold SV, Chan PS, Jones PG, Decker C, Buchanan DM, Krumholz HM, Ho PM, Spertus JA. Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH). Circulation Cardiovascular Quality And Outcomes 2011, 4: 467-476. PMID: 21772003, PMCID: PMC3376532, DOI: 10.1161/circoutcomes.110.960468.Peer-Reviewed Original ResearchConceptsHealth status studiesMyocardial infarctionHealth statusPostdischarge careAcute Myocardial Infarction Patients' Health StatusSubset of patientsTranslational researchPost-MI outcomesRacial differencesHigh mortality ratePatients' health statusMI registryChart abstractionHospital dischargeWhite patientsBlack patientsVital statusMedical historyWorse outcomesTreatment characteristicsInpatient careBaseline interviewUS CentersBlood samplesPatients
2007
Acute Coronary Care in the Elderly, Part I
Alexander KP, Newby LK, Cannon CP, Armstrong PW, Gibler WB, Rich MW, Van de Werf F, White HD, Weaver WD, Naylor MD, Gore JM, Krumholz HM, Ohman EM. Acute Coronary Care in the Elderly, Part I. Circulation 2007, 115: 2549-2569. PMID: 17502590, DOI: 10.1161/circulationaha.107.182615.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAge FactorsAgedAged, 80 and overAngina, UnstableAngioplasty, Balloon, CoronaryAnticoagulantsCardiac CatheterizationClinical Trials as TopicComorbidityCreatinineDisease ManagementDisease SusceptibilityDose-Response Relationship, DrugEvidence-Based MedicineFemaleHospital MortalityHumansKidneyLife ExpectancyMaleMetabolic Clearance RateMulticenter Studies as TopicMyocardial InfarctionPlatelet Aggregation InhibitorsPractice Guidelines as TopicRegistriesRisk AssessmentRisk FactorsStentsTreatment OutcomeConceptsAcute coronary syndromeElderly patientsOlder patientsInvasive treatmentSegment elevation acute coronary syndromesAmerican Heart Association scientific statementST-segment elevation myocardial infarctionElevation acute coronary syndromeComplex health statusAcute coronary careSubset of patientsAcute cardiac diseaseAge subgroup analysisTreatment-related benefitsGuideline-based careTreatment-related risksOutcomes of importanceQuality of lifeLimited trial dataCommunity practiceBasis of ageApplication of evidenceHigher disease riskGeriatric perspectiveCoronary syndrome
2006
Acute, Severe Noncardiac Conditions in Patients with Acute Myocardial Infarction
Lichtman JH, Fathi A, Radford MJ, Lin Z, Loeser CS, Krumholz HM. Acute, Severe Noncardiac Conditions in Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2006, 119: 843-850. PMID: 17000215, DOI: 10.1016/j.amjmed.2006.03.040.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac conditionsHospital mortalityPrognostic importanceMyocardial infarctionMortality riskYale-New Haven HospitalExcessive mortality riskHospital mortality riskSubgroup of patientsSubset of patientsRisk-adjusted analysisRisk of deathMultivariable logistic modelCardiac severityInitial therapyConsecutive patientsClinical presentationMultivariable analysisMedical historyPatientsPatient recordsMortalityMarked increaseInfarction
2001
Predictors of costs of caring for elderly patients discharged with heart failure
Wexler D, Chen J, Smith G, Radford M, Yaari S, Bradford W, Krumholz H. Predictors of costs of caring for elderly patients discharged with heart failure. American Heart Journal 2001, 142: 350-357. PMID: 11479477, DOI: 10.1067/mhj.2001.116476.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overConnecticutFemaleHealth Services for the AgedHeart FailureHospital CostsHumansLength of StayMaleMedical RecordsMedicareModels, EconomicOutcome Assessment, Health CarePatient DischargePatient ReadmissionPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsConceptsHeart failureIndependent correlatesHeart failure-related admissionsHeart failure-related readmissionsSubstantial hospital costsHeart failure admissionsHistory of strokeSubset of patientsPrincipal discharge diagnosisSignificant independent correlatesOutcomes 6 monthsPredictors of costsMedicare administrative databasesCause readmissionClinical characteristicsElderly patientsAverage admissionDischarge diagnosisKidney failureCause costsCorrelates of costsMedical recordsRisk factorsAdministrative databasesConnecticut hospitals