2020
Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research
Bikdeli B, Madhavan MV, Gupta A, Jimenez D, Burton JR, Der Nigoghossian C, Chuich T, Nouri SN, Dreyfus I, Driggin E, Sethi S, Sehgal K, Chatterjee S, Ageno W, Madjid M, Guo Y, Tang LV, Hu Y, Bertoletti L, Giri J, Cushman M, Quéré I, Dimakakos EP, Gibson CM, Lippi G, Favaloro EJ, Fareed J, Tafur AJ, Francese DP, Batra J, Falanga A, Clerkin KJ, Uriel N, Kirtane A, McLintock C, Hunt BJ, Spyropoulos AC, Barnes GD, Eikelboom JW, Weinberg I, Schulman S, Carrier M, Piazza G, Beckman JA, Leon MB, Stone GW, Rosenkranz S, Goldhaber SZ, Parikh SA, Monreal M, Krumholz HM, Konstantinides SV, Weitz JI, Lip GYH, Group T. Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research. Thrombosis And Haemostasis 2020, 120: 1004-1024. PMID: 32473596, PMCID: PMC7516364, DOI: 10.1055/s-0040-1713152.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2COVID-19Respiratory syndrome coronavirus 2Subgroup of patientsCOVID-19 patientsFuture prospective studiesManagement of thrombosisSyndrome coronavirus 2Coronavirus disease 2019Mechanism of actionViral illnessThrombotic eventsRandomized trialsProspective studyAntithrombotic effectCoronavirus 2Antithrombotic agentsAntithrombotic drugsAntiviral effectDisease 2019Thrombotic diseaseAntithrombotic propertiesDosing approachWorldwide pandemic
2018
Association of Body Mass Index With Blood Pressure Among 1.7 Million Chinese Adults
Linderman GC, Lu J, Lu Y, Sun X, Xu W, Nasir K, Schulz W, Jiang L, Krumholz HM. Association of Body Mass Index With Blood Pressure Among 1.7 Million Chinese Adults. JAMA Network Open 2018, 1: e181271-e181271. PMID: 30646115, PMCID: PMC6324286, DOI: 10.1001/jamanetworkopen.2018.1271.Peer-Reviewed Original ResearchConceptsBody mass indexSystolic blood pressureBlood pressureAntihypertensive medicationsMass indexMean (SD) BMIMean (SD) systolic BPIncrease of BPUnit body mass indexPrimary health care sitesComprehensive subgroup analysisMillion Persons ProjectDiastolic blood pressureSubgroup of patientsCross-sectional studyElectronic BP monitorsHealth care sitesSubgroup of individualsUntreated subgroupSubgroup analysisCare sitesBP monitorMAIN OUTCOMEChinese adultsChinese population
2009
Relationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Goyal A, Krumholz HM, Masoudi FA, Xiao L, Spertus JA. Relationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction. JAMA 2009, 301: 1556-1564. PMID: 19366775, DOI: 10.1001/jama.2009.496.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionInsulin therapyHospital mortalityIatrogenic hypoglycemiaHypoglycemic eventsMyocardial infarctionMortality riskGlucose-lowering therapyRetrospective cohort studySubgroup of patientsHigher mortality riskLogistic regression modelsMore comorbiditiesSubsequent hospitalizationMultivariable adjustmentCohort studyGlucose loweringGlucose controlEpisodic hypoglycemiaMAIN OUTCOMEHypoglycemiaPatientsHealth FactsHigh mortalityTherapy
2006
Acute, Severe Noncardiac Conditions in Patients with Acute Myocardial Infarction
Lichtman JH, Fathi A, Radford MJ, Lin Z, Loeser CS, Krumholz HM. Acute, Severe Noncardiac Conditions in Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2006, 119: 843-850. PMID: 17000215, DOI: 10.1016/j.amjmed.2006.03.040.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac conditionsHospital mortalityPrognostic importanceMyocardial infarctionMortality riskYale-New Haven HospitalExcessive mortality riskHospital mortality riskSubgroup of patientsSubset of patientsRisk-adjusted analysisRisk of deathMultivariable logistic modelCardiac severityInitial therapyConsecutive patientsClinical presentationMultivariable analysisMedical historyPatientsPatient recordsMortalityMarked increaseInfarction
1999
Gender differences in symptom presentation associated with coronary heart disease
Milner K, Funk M, Richards S, Wilmes R, Vaccarino V, Krumholz H. Gender differences in symptom presentation associated with coronary heart disease. The American Journal Of Cardiology 1999, 84: 396-399. PMID: 10468075, DOI: 10.1016/s0002-9149(99)00322-7.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseNon-chest pain symptomsChest painEmergency departmentPain symptomsUnadjusted analysesHeart diseaseSymptom presentationYale-New Haven HospitalSubgroup of patientsNurse data collectorsGender differencesMidback painProspective studyPainNauseaVomitingSymptomsPatientsWomenDyspneaSignificant gender differencesMenDiseaseIndigestion