2023
Opportunities and Achievement of Medication Initiation Among Inpatients With Heart Failure With Reduced Ejection Fraction
Swat S, Xu H, Allen L, Greene S, DeVore A, Matsouaka R, Goyal P, Peterson P, Hernandez A, Krumholz H, Yancy C, Fonarow G, Hess P, Program A. Opportunities and Achievement of Medication Initiation Among Inpatients With Heart Failure With Reduced Ejection Fraction. JACC Heart Failure 2023, 11: 918-929. PMID: 37318420, DOI: 10.1016/j.jchf.2023.04.015.Peer-Reviewed Original ResearchConceptsEvidence-based medicationsMedication initiationReduced ejection fractionNumber of medicationsMultivariable logistic regressionNumber of patientsPre-existing conditionsReduced ejectionEjection fractionHeart failureMultivariable analysisFemale sexLower oddsMedicationsMean net gainPatientsRural hospitalsAdmissionOlder ageLogistic regressionStudy periodMean numberOddsInitiationRural locations
2017
Urban–Rural Comparisons in Hospital Admission, Treatments, and Outcomes for ST-Segment–Elevation Myocardial Infarction in China From 2001 to 2011
Li X, Murugiah K, Li J, Masoudi FA, Chan PS, Hu S, Spertus JA, Wang Y, Downing NS, Krumholz HM, Jiang L. Urban–Rural Comparisons in Hospital Admission, Treatments, and Outcomes for ST-Segment–Elevation Myocardial Infarction in China From 2001 to 2011. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003905. PMID: 29158421, PMCID: PMC6312853, DOI: 10.1161/circoutcomes.117.003905.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChinaDisease ManagementFemaleHealthcare DisparitiesHospital MortalityHospitalizationHospitals, RuralHospitals, UrbanHumansMaleMiddle AgedOdds RatioQuality ImprovementRetrospective StudiesRural PopulationST Elevation Myocardial InfarctionSurvival RateTime FactorsUrban PopulationConceptsEvidence-based treatmentsMyocardial infarctionEnzyme inhibitors/angiotensin receptor blockersRural hospitalsST-segment elevation myocardial infarctionUrban-rural disparitiesAngiotensin receptor blockersElevation myocardial infarctionAdjusted odds ratioResource-intensive careRisk-adjusted ratesHospital deathReperfusion therapyReceptor blockersHospital admissionCardiac facilitiesPatient outcomesOdds ratioCare persistUrban hospitalΒ-blockersBetter outcomesRural careHealthcare resourcesST segment
2015
10 year trends in urban–rural disparities in treatments and outcomes after ST-elevation myocardial infarction in China: insights from the China PEACE-Retrospective Acute Myocardial Infarction Study
Li X, Murugiah K, Li J, Wang Q, Hu S, Masoudi F, Spertus J, Downing N, Chan P, Krumholz H, Jiang L, Group C. 10 year trends in urban–rural disparities in treatments and outcomes after ST-elevation myocardial infarction in China: insights from the China PEACE-Retrospective Acute Myocardial Infarction Study. The Lancet 2015, 386: s2. DOI: 10.1016/s0140-6736(15)00580-2.Peer-Reviewed Original ResearchST-segment elevation myocardial infarctionCase of STEMIUrban hospitalRural hospitalsMyocardial infarctionAcute Myocardial Infarction StudyST-elevation myocardial infarctionMedical chart abstractionACEI/ARBMyocardial Infarction StudyElevation myocardial infarctionMedical record abstractionAdjusted odds ratioCertain clinical conditionsTwo-stage random sampling designQuality of careRisk-adjusted ratesCompleteness of documentationHospital complicationsHospital mortalityHospital deathReperfusion therapyChart abstractionComposite outcomeFamily Planning CommissionNational Quality Assessment of Early Clopidogrel Therapy in Chinese Patients With Acute Myocardial Infarction (AMI) in 2006 and 2011: Insights From the China Patient‐Centered Evaluative Assessment of Cardiac Events (PEACE)–Retrospective AMI Study
Zhang L, Desai NR, Li J, Hu S, Wang Q, Li X, Masoudi FA, Spertus JA, Nuti SV, Wang S, Krumholz HM, Jiang L, Group T. National Quality Assessment of Early Clopidogrel Therapy in Chinese Patients With Acute Myocardial Infarction (AMI) in 2006 and 2011: Insights From the China Patient‐Centered Evaluative Assessment of Cardiac Events (PEACE)–Retrospective AMI Study. Journal Of The American Heart Association 2015, 4: e001906. PMID: 26163041, PMCID: PMC4608074, DOI: 10.1161/jaha.115.001906.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsian PeopleChinaClopidogrelDrug Administration ScheduleFemaleHealthcare DisparitiesHumansMaleMiddle AgedMyocardial InfarctionNational Health ProgramsPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPractice Patterns, Physicians'Quality ImprovementQuality Indicators, Health CareResidence CharacteristicsRetrospective StudiesRisk FactorsRural Health ServicesTiclopidineTime FactorsTreatment OutcomeUrban Health ServicesConceptsAcute myocardial infarctionEarly clopidogrel useClopidogrel therapyClopidogrel useRural hospitalsMyocardial infarctionQuality improvement initiativesEligible patientsClopidogrel administrationReperfusion therapyCardiac eventsHospital admissionAMI patientsChina PatientChinese patientsPatterns of useUrban hospitalPatientsClopidogrelChinese trialsHospitalTherapyEarly useAMI studyImprovement initiativesWide Variation Found In Hospital Facility Costs For Maternity Stays Involving Low-Risk Childbirth
Xu X, Gariepy A, Lundsberg LS, Sheth SS, Pettker CM, Krumholz HM, Illuzzi JL. Wide Variation Found In Hospital Facility Costs For Maternity Stays Involving Low-Risk Childbirth. Health Affairs 2015, 34: 1212-1219. PMID: 26153317, DOI: 10.1377/hlthaff.2014.1088.Peer-Reviewed Original ResearchConceptsCesarean deliveryHospital costsMaternity staysSerious maternal morbidityNationwide Inpatient SampleCoordination of careValue of careMaternal morbidityHospital admissionInpatient SampleDelivery system reformRural hospitalsUS hospitalsHospital practiceSafe reductionHospitalChildbirthStayLong stayHigh rateCareLower proportionUnited StatesFacility costs
2011
National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention
Herrin J, Miller LE, Turkmani DF, Nsa W, Drye EE, Bernheim SM, Ling SM, Rapp MT, Han LF, Bratzler DW, Bradley EH, Nallamothu BK, Ting HH, Krumholz HM. National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 171: 1879-1886. PMID: 22123793, PMCID: PMC4312661, DOI: 10.1001/archinternmed.2011.481.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionDIDO timeCoronary interventionST-segment elevation acute myocardial infarctionMixed-effects multivariable modelElevation acute myocardial infarctionPrimary percutaneous coronary interventionMedian DIDO timeAcute myocardial infarctionFibrinolytic therapyPatient characteristicsMultivariable analysisEmergency departmentMyocardial infarctionHospital characteristicsMultivariable modelPatientsRural hospitalsHospitalMedicaid ServicesAge categoriesInterventionAfrican AmericansMinutesTreatment time
2008
Hospital Remoteness And Thirty-Day Mortality From Three Serious Conditions
Ross JS, Normand SL, Wang Y, Nallamothu BK, Lichtman JH, Krumholz HM. Hospital Remoteness And Thirty-Day Mortality From Three Serious Conditions. Health Affairs 2008, 27: 1707-1717. PMID: 18997230, DOI: 10.1377/hlthaff.27.6.1707.Peer-Reviewed Original ResearchConceptsRisk-standardized mortality ratesThirty-day mortalityAcute myocardial infarctionHigh-quality health careMedicare administrative dataGeographic remotenessHeart failureMyocardial infarctionSerious conditionMillions of AmericansRural U.S. communitiesMortality differencesMortality rateRural hospitalsSmaller mortality differencesHealth careAdministrative dataHospitalU.S. communitiesCareHospitalizationInfarctionPneumoniaMortality