2020
Presentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study
Gupta A, Tsang S, Hajduk A, Krumholz HM, Nanna MG, Green P, Dodson JA, Chaudhry SI. Presentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2020, 134: 95-103. PMID: 32805225, PMCID: PMC7752813, DOI: 10.1016/j.amjmed.2020.07.020.Peer-Reviewed Original ResearchConceptsOldest-old patientsMyocardial infarctionFunctional impairmentOlder patientsMobility impairmentsCox proportional hazards regressionMiddle-old patientsProportional hazards regressionAcute myocardial infarctionCase fatality rateAcute myocardial infarction hospitalizationsSILVER-AMI StudyYears of ageMyocardial infarction hospitalizationsChest painCoronary revascularizationAtypical presentationHazards regressionClinical variablesRisk factorsAdvanced agePrimary symptomsPatientsFatality rateHealth status
2016
Association of Guideline-Based Admission Treatments and Life Expectancy After Myocardial Infarction in Elderly Medicare Beneficiaries
Bucholz EM, Butala NM, Normand SL, Wang Y, Krumholz HM. Association of Guideline-Based Admission Treatments and Life Expectancy After Myocardial Infarction in Elderly Medicare Beneficiaries. Journal Of The American College Of Cardiology 2016, 67: 2378-2391. PMID: 27199062, PMCID: PMC5097252, DOI: 10.1016/j.jacc.2016.03.507.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAspirinFemaleFollow-Up StudiesGuideline AdherenceHospitalizationHumansLife ExpectancyMaleMedicareMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPractice Guidelines as TopicThrombolytic TherapyTime-to-TreatmentUnited StatesConceptsAcute myocardial infarctionPrimary percutaneous coronary interventionGuideline-based therapyYears of lifeAdmission therapyLife expectancyMyocardial infarctionMedicare beneficiariesCox proportional hazards regressionAcute reperfusion therapyLate survival benefitReceipt of aspirinPercutaneous coronary interventionLong-term outcomesProportional hazards regressionCooperative Cardiovascular ProjectElderly Medicare beneficiariesDose-response relationshipAssociation of GuidelineShort life expectancyLonger life expectancyReperfusion therapyCoronary interventionD2B timeElderly patientsUnderweight, Markers of Cachexia, and Mortality in Acute Myocardial Infarction: A Prospective Cohort Study of Elderly Medicare Beneficiaries
Bucholz EM, Krumholz HA, Krumholz HM. Underweight, Markers of Cachexia, and Mortality in Acute Myocardial Infarction: A Prospective Cohort Study of Elderly Medicare Beneficiaries. PLOS Medicine 2016, 13: e1001998. PMID: 27093615, PMCID: PMC4836735, DOI: 10.1371/journal.pmed.1001998.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overBody Mass IndexCachexiaComorbidityFemaleFrail ElderlyGeriatric AssessmentHospital MortalityHumansInsurance BenefitsKaplan-Meier EstimateMaleMedicareMyocardial InfarctionNutrition AssessmentNutritional StatusPrevalencePrognosisProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsThinnessTime FactorsUnited StatesConceptsLower body mass indexNormal weight patientsBody mass indexAcute myocardial infarctionUnderweight patientsWeight patientsSubset of patientsHigh riskFrailty measuresLaboratory markersMyocardial infarctionMedicare beneficiariesNutritional statusCox proportional hazards regressionUnderweight body mass indexMarkers of cachexiaLong-term mortalityProspective cohort studyCohort-based studyMeasures of frailtyProportional hazards regressionCooperative Cardiovascular ProjectElderly Medicare beneficiariesImportant risk factorSignificant chronic illnessIncidence and Determinants of Traumatic Intracranial Bleeding Among Older Veterans Receiving Warfarin for Atrial Fibrillation
Dodson JA, Petrone A, Gagnon DR, Tinetti ME, Krumholz HM, Gaziano JM. Incidence and Determinants of Traumatic Intracranial Bleeding Among Older Veterans Receiving Warfarin for Atrial Fibrillation. JAMA Cardiology 2016, 1: 65. PMID: 27437657, PMCID: PMC5600874, DOI: 10.1001/jamacardio.2015.0345.Peer-Reviewed Original ResearchConceptsTraumatic intracranial bleedingIntracranial bleedingInternational normalized ratioIschemic strokeAtrial fibrillationIncidence rateAnticonvulsant useWarfarin therapyNormalized ratioRisk factorsOlder adultsVeterans AffairsCox proportional hazards regressionVA electronic medical recordsMean patient agePatients 75 yearsRetrospective cohort studyClinical Modification codesCoronary artery diseaseProportional hazards regressionService claims dataVA administrative dataSignificant predictorsHealth care professionalsElectronic medical recordsSlow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry
Dodson JA, Arnold SV, Gosch KL, Gill TM, Spertus JA, Krumholz HM, Rich MW, Chaudhry SI, Forman DE, Masoudi FA, Alexander KP. Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry. Journal Of The American Geriatrics Society 2016, 64: 596-601. PMID: 26926309, PMCID: PMC4803531, DOI: 10.1111/jgs.14016.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionSlow gaitHospital readmissionGait speedOlder adultsCox proportional hazards regressionMarker of frailtySlow gait speedTranslational researchProportional hazards regressionOutcomes 1 yearRisk of mortalityAssessment 1 monthBaseline characteristicsObservational cohortClinical factorsDiabetes mellitusHeart failureHazards regressionPrognostic importancePrognostic valueHigh prevalenceInfarctionReadmission
2015
Life Expectancy and Years of Potential Life Lost After Acute Myocardial Infarction by Sex and Race A Cohort-Based Study of Medicare Beneficiaries
Bucholz EM, Normand SL, Wang Y, Ma S, Lin H, Krumholz HM. Life Expectancy and Years of Potential Life Lost After Acute Myocardial Infarction by Sex and Race A Cohort-Based Study of Medicare Beneficiaries. Journal Of The American College Of Cardiology 2015, 66: 645-655. PMID: 26248991, PMCID: PMC5459400, DOI: 10.1016/j.jacc.2015.06.022.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionWhite patientsBlack patientsLife expectancyMyocardial infarctionMedicare beneficiariesCox proportional hazards regressionPotential lifeProspective cohort studyCohort-based studyProportional hazards regressionCooperative Cardiovascular ProjectBurden of diseaseLong-term survivalCohort studyClinical presentationHazards regressionBlack raceSurvival advantageGeneral populationPatientsAverage ageRace differencesLife expectancy estimatesYPLLNational Trends in Hospital Readmission Rates among Medicare Fee-for-Service Survivors of Mitral Valve Surgery, 1999–2010
Dodson JA, Wang Y, Murugiah K, Dharmarajan K, Cooper Z, Hashim S, Nuti SV, Spatz E, Desai N, Krumholz HM. National Trends in Hospital Readmission Rates among Medicare Fee-for-Service Survivors of Mitral Valve Surgery, 1999–2010. PLOS ONE 2015, 10: e0132470. PMID: 26147225, PMCID: PMC4493110, DOI: 10.1371/journal.pone.0132470.Peer-Reviewed Original ResearchConceptsMitral valve surgeryLength of stayHospital LOSReadmission ratesHospital readmission ratesOlder patientsHospital readmissionMedicare feeMean hospital LOSSurvival rateProportional hazards regressionYears of ageValve surgeryHazards regressionService patientsWorse outcomesAge subgroupsPatientsOlder adultsSurvivorsNational trendsReadmissionModest declineWomenSubgroups
2012
Body Mass Index and Mortality in Acute Myocardial Infarction Patients
Bucholz EM, Rathore SS, Reid KJ, Jones PG, Chan PS, Rich MW, Spertus JA, Krumholz HM. Body Mass Index and Mortality in Acute Myocardial Infarction Patients. The American Journal Of Medicine 2012, 125: 796-803. PMID: 22483510, PMCID: PMC3408565, DOI: 10.1016/j.amjmed.2012.01.018.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexAcute myocardial infarctionMyocardial infarctionLower mortalityObesity paradoxMass indexAssociation of BMIMedian body mass indexCox proportional hazards regressionAcute myocardial infarction patientsImpact of obesityRegistry of patientsProportional hazards regressionMyocardial infarction patientsContinuous variablesDomains of patientsDiabetes subgroupsClinical characteristicsMultivariable adjustmentHeart failurePatient characteristicsBMI groupsDiabetes mellitusHazards regression
2008
Cerebrovascular Disease Risk in Older Head and Neck Cancer Patients After Radiotherapy
Smith GL, Smith BD, Buchholz TA, Giordano SH, Garden AS, Woodward WA, Krumholz HM, Weber RS, Ang K, Rosenthal DI. Cerebrovascular Disease Risk in Older Head and Neck Cancer Patients After Radiotherapy. Journal Of Clinical Oncology 2008, 26: 5119-5125. PMID: 18725647, PMCID: PMC4879715, DOI: 10.1200/jco.2008.16.6546.Peer-Reviewed Original ResearchConceptsCerebrovascular disease riskNeck cancer patientsDisease riskCerebrovascular eventsCerebrovascular riskCardiac riskCancer patientsNeck cancerTreatment groupsTen-year incidenceProportional hazards regressionDefinitive radiotherapyPostoperative radiotherapyCardiac eventsOlder patientsCerebrovascular diseaseHazards regressionNonmetastatic headMean ageVascular diseaseBaseline riskPatientsSurgeryRadiotherapyControl diagnosis
2006
Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death
Heidenreich PA, Spertus JA, Jones PG, Weintraub WS, Rumsfeld JS, Rathore SS, Peterson ED, Masoudi FA, Krumholz HM, Havranek EP, Conard MW, Williams RE, Consortium C. Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death. Journal Of The American College Of Cardiology 2006, 47: 752-756. PMID: 16487840, DOI: 10.1016/j.jacc.2005.11.021.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireB-type natriuretic peptideKCCQ summary scoreHeart failureKCCQ scoresHealth status measuresClinical conditionsNew York Heart Association functional class IVSummary scoresStatus measuresFunctional class IVIschemic HF etiologyLower KCCQ scoresSequential multivariable modelsBaseline patient characteristicsHeart failure outpatientsPatient's clinical conditionProportional hazards regressionBNP levelsHF etiologyHF hospitalizationHF admissionsHF patientsPatient characteristicsWalk distance
2003
The prognostic importance of anemia in patients with heart failure
Kosiborod M, Smith GL, Radford MJ, Foody JM, Krumholz HM. The prognostic importance of anemia in patients with heart failure. The American Journal Of Medicine 2003, 114: 112-119. PMID: 12586230, DOI: 10.1016/s0002-9343(02)01498-5.Peer-Reviewed Original ResearchConceptsHeart failureLow hematocritHospital readmissionPrognostic importanceHematocrit levelsMultivariate Cox proportional hazards regressionLeft ventricular ejection fractionCox proportional hazards regressionTraditional risk factorsVentricular ejection fractionPrincipal discharge diagnosisProportional hazards regressionRisk of deathElderly patientsOlder patientsClinical factorsEjection fractionIndependent predictorsDischarge diagnosisHazards regressionMedian hematocritPrognostic valueMean ageTreatable conditionRisk factors
2001
Depression and Risk of Heart Failure Among Older Persons With Isolated Systolic Hypertension
Abramson J, Berger A, Krumholz HM, Vaccarino V. Depression and Risk of Heart Failure Among Older Persons With Isolated Systolic Hypertension. JAMA Internal Medicine 2001, 161: 1725-1730. PMID: 11485505, DOI: 10.1001/archinte.161.14.1725.Peer-Reviewed Original ResearchConceptsHeart failureSystolic hypertensionMyocardial infarctionDepressed personsOlder personsCox proportional hazards regressionEpidemiological Studies Depression ScaleIsolated systolic hypertensionIncident heart failureCoronary heart diseaseProportional hazards regressionBlood pressureElectrocardiographic abnormalitiesHazards regressionElderly ProgramCholesterol levelsHeart diseaseRisk factorsNondepressed personsDepression ScaleAdditional adjustmentElevated riskHigh riskTreatment groupsHypertension