2012
Discontinuation of Antihyperglycemic Therapy After Acute Myocardial Infarction: Medical Necessity or Medical Error?
Lovig KO, Horwitz L, Lipska K, Kosiborod M, Krumholz HM, Inzucchi SE. Discontinuation of Antihyperglycemic Therapy After Acute Myocardial Infarction: Medical Necessity or Medical Error? The Joint Commission Journal On Quality And Patient Safety 2012, 38: 403-407. PMID: 23002492, PMCID: PMC3534988, DOI: 10.1016/s1553-7250(12)38051-3.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionLeft ventricular ejection fractionAntihyperglycemic therapyDiabetic patientsMyocardial infarctionMedical necessityOne-year mortalityDetailed chart reviewVentricular ejection fractionIschemic heart diseaseNational Medicare databaseMedical errorsAcademic medical centerQuality improvement opportunitiesChart reviewClinical characteristicsOlder patientsRecurrent hypoglycemiaEjection fractionMedicare databaseBlood glucoseHeart diseasePrincipal diagnosisCommunity hospitalMedical Center
2006
National Trends in Outcomes Among Elderly Patients with Heart Failure
Kosiborod M, Lichtman JH, Heidenreich PA, Normand SL, Wang Y, Brass LM, Krumholz HM. National Trends in Outcomes Among Elderly Patients with Heart Failure. The American Journal Of Medicine 2006, 119: 616.e1-616.e7. PMID: 16828634, DOI: 10.1016/j.amjmed.2005.11.019.Peer-Reviewed Original ResearchConceptsHeart failure managementHeart failureElderly patientsHospital readmissionFailure managementOne-year mortalityThirty-day readmissionRisk-adjusted analysisCause hospital readmissionReferent yearCause mortalityReadmissionMedicare beneficiariesBetter outcomesMortality trendsMortalityPatientsRisk adjustmentTemporal trendsNational trendsOutcomesNational sampleFailureYears
2005
77 ADMISSION BODY TEMPERATURE AND MORTALITY IN PATIENTS HOSPITALIZED FOR HEART FAILURE
Nallamothu B, Payvar S, Wang Y, Kosiborod M, Foody J, Masoudi F, Havranek E, Casscells S, Krumholz H. 77 ADMISSION BODY TEMPERATURE AND MORTALITY IN PATIENTS HOSPITALIZED FOR HEART FAILURE. Journal Of Investigative Medicine 2005, 53: s400. DOI: 10.2310/6650.2005.00205.76.Peer-Reviewed Original ResearchOne-year mortalityAdmission body temperatureHeart failureWorse survivalBody temperatureLow body temperatureLogistic regressionPatients 65 yearsAdvanced heart failurePATIENTS HOSPITALIZEDHospital deathMultivariate adjustmentPatient subgroupsIndependent associationClinical dataStudy populationPatientsPolynomial logistic regressionCare ProjectMortalityHospitalSurvivalFailureSignificant relationshipHospitalized
2001
Acute myocardial infarction in the elderly: differences by age
Mehta R, Rathore S, Radford M, Wang Y, Wang Y, Krumholz H. Acute myocardial infarction in the elderly: differences by age. Journal Of The American College Of Cardiology 2001, 38: 736-741. PMID: 11527626, DOI: 10.1016/s0735-1097(01)01432-2.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAge-associated differencesElderly patientsClinical characteristicsAge groupsMyocardial infarctionThirty-day mortality rateMedicare beneficiaries ageOne-year mortalityPrior coronary diseaseProportion of patientsST-segment elevationOlder age groupsSignificant age-associated differencesChest painEffect of ageOlder patientsRenal insufficiencyCoronary diseaseHeart failureHospital admissionPatient characteristicsSuccessive age groupsSymptom onsetDiabetic patientsPredicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project
Krumholz H, Chen J, Chen Y, Wang Y, Radford M. Predicting one-year mortality among elderly survivors of hospitalization for an acute myocardial infarction: results from the Cooperative Cardiovascular Project. Journal Of The American College Of Cardiology 2001, 38: 453-459. PMID: 11499737, DOI: 10.1016/s0735-1097(01)01395-x.Peer-Reviewed Original ResearchConceptsOne-year mortalityAcute myocardial infarctionMyocardial infarctionPeripheral vascular diseaseCohort of patientsBody mass indexCooperative Cardiovascular ProjectRisk of mortalityDeath one yearPopulation-based sampleSimple risk modelRenal dysfunctionVentricular dysfunctionElderly patientsOlder patientsUrinary incontinenceHeart failureMass indexAcute carePrognostic importanceMean ageVascular diseaseMedical recordsRisk groupsOlder survivorsEffectiveness of beta-blocker therapy after acute myocardial infarction in elderly patients with chronic obstructive pulmonary disease or asthma
Chen J, Radford M, Wang Y, Marciniak T, Krumholz H. Effectiveness of beta-blocker therapy after acute myocardial infarction in elderly patients with chronic obstructive pulmonary disease or asthma. Journal Of The American College Of Cardiology 2001, 37: 1950-1956. PMID: 11401137, DOI: 10.1016/s0735-1097(01)01225-6.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseBeta-blocker therapyAcute myocardial infarctionOne-year mortalityObstructive pulmonary diseasePulmonary diseaseElderly patientsSurvival benefitMyocardial infarctionSevere chronic obstructive pulmonary diseaseBeta-agonist therapyElderly AMI patientsSevere pulmonary diseaseCooperative Cardiovascular ProjectAsthma patientsClinical factorsAMI patientsMild diseaseClinical trialsDischarge useSevere diseaseAsthmaPatientsTherapyDisease
1999
Beta-blocker therapy for secondary prevention of myocardial infarction in elderly diabetic patients
Chen J, Marciniak T, Radford M, Wang Y, Krumholz H. Beta-blocker therapy for secondary prevention of myocardial infarction in elderly diabetic patients. Journal Of The American College Of Cardiology 1999, 34: 1388-1394. PMID: 10551683, DOI: 10.1016/s0735-1097(99)00383-6.Peer-Reviewed Original ResearchConceptsBeta-blocker therapyElderly diabetic patientsAcute myocardial infarctionInsulin-treated diabeticsOne-year mortalityDiabetic patientsDiabetic complicationsMyocardial infarctionNational Cooperative Cardiovascular ProjectSix-month readmission ratesOne-year mortality rateRetrospective cohort studyRisk of readmissionHospital medical recordsCooperative Cardiovascular ProjectCommunity practice settingsElderly diabeticsCohort studyComplication rateReadmission ratesSecondary preventionClinical factorsHospital readmissionRandomized trialsPotential confounders
1995
A cost-effectiveness model of thrombolytic therapy for acute myocardial infarction
Kalish S, Gurwitz J, Krumholz H, Avorn J. A cost-effectiveness model of thrombolytic therapy for acute myocardial infarction. Journal Of General Internal Medicine 1995, 10: 321-330. PMID: 7562123, DOI: 10.1007/bf02599951.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsTissue plasminogen activatorAcute myocardial infarctionAdditional quality-adjusted life yearMyocardial infarctionGUSTO trialThrombolytic therapyOne-year mortality dataOccluded Coronary Arteries (GUSTO-I) trialMortality dataPlasminogen activatorLong-term medical costsCoronary Arteries trialOne-year mortalityUse of streptokinaseInferior wall infarctionCost-effective therapyCost-effectiveness modelDecision analysis modelSurvival benefitSymptom onsetClinical outcomesRelative survival advantageThrombolytic agentsSurvival advantage