2022
Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non–ST-Segment–Elevation Myocardial Infarction in China: 2006 to 2015
Guo W, Du X, Gao Y, Hu S, Lu Y, Dreyer RP, Li X, Spatz ES, Masoudi FA, Krumholz HM, Zheng X. Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non–ST-Segment–Elevation Myocardial Infarction in China: 2006 to 2015. Circulation Cardiovascular Quality And Outcomes 2022, 15: e008535. PMID: 35607994, PMCID: PMC9208815, DOI: 10.1161/circoutcomes.121.008535.Peer-Reviewed Original ResearchConceptsSegment elevation myocardial infarctionInvasive strategyMyocardial infarctionHospital mortalityHospital outcomesMultivariable logistic regression modelCardiovascular risk factorsElevation myocardial infarctionSex-related disparitiesQuality of careProportion of womenLogistic regression modelsSex differencesClinical characteristicsClinical profileRisk factorsClinical covariatesSex-specific differencesPatientsInfarctionST segmentSex gapChinese hospitalsMortalityWomen
2015
Hospital Variability in Use of Anticoagulant Strategies During Acute Myocardial Infarction Treated With an Early Invasive Strategy
Arnold SV, Li SX, Alexander KP, Spertus JA, Nallamothu BK, Curtis JP, Kosiborod M, Gupta A, Wang TY, Lin H, Dharmarajan K, Strait KM, Lowe TJ, Krumholz HM. Hospital Variability in Use of Anticoagulant Strategies During Acute Myocardial Infarction Treated With an Early Invasive Strategy. Journal Of The American Heart Association 2015, 4: e002009. PMID: 26077589, PMCID: PMC4599539, DOI: 10.1161/jaha.115.002009.Peer-Reviewed Original ResearchConceptsEarly invasive strategyAnticoagulant strategiesMyocardial infarctionBleeding rateInvasive strategyAcute myocardial infarction patientsOptimal anticoagulant strategyHalf of patientsPercutaneous coronary interventionAcute myocardial infarctionMyocardial infarction patientsHospital use patternsComparative effectiveness studiesRisk-standardized mortalityChoice of anticoagulantsMedian odds ratioCoronary interventionPatient factorsSystemic anticoagulationHospital variabilityInfarction patientsPrincipal diagnosisOdds ratioMultivariate regression modelPatterns of use
2008
An early invasive strategy versus ischemia-guided management after fibrinolytic therapy for ST-segment elevation myocardial infarction: A meta-analysis of contemporary randomized controlled trials
Wijeysundera HC, You JJ, Nallamothu BK, Krumholz HM, Cantor WJ, Ko DT. An early invasive strategy versus ischemia-guided management after fibrinolytic therapy for ST-segment elevation myocardial infarction: A meta-analysis of contemporary randomized controlled trials. American Heart Journal 2008, 156: 564-572.e2. PMID: 18760142, DOI: 10.1016/j.ahj.2008.04.024.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryCardiac CatheterizationElectrocardiographyFemaleFibrinolytic AgentsHemorrhageHumansInjections, IntravenousInpatientsMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaMyocardial ReperfusionRandomized Controlled Trials as TopicRecurrenceStentsStrokeThrombolytic TherapyConceptsST-segment elevation myocardial infarctionEarly invasive strategyPercutaneous coronary interventionElevation myocardial infarctionFibrinolytic therapyInvasive strategyMajor bleedingSTEMI patientsMyocardial infarctionHospital major bleedingIntravenous fibrinolytic therapyLarge randomized trialsRisk of strokeSignificant reductionCause mortalityEligible trialsCoronary interventionRandomized trialsContemporary trialsStent useInclusion criteriaPatientsReinfarctionTherapyTrialsRegional Variation in Cardiac Catheterization Appropriateness and Baseline Risk After Acute Myocardial Infarction
Ko DT, Wang Y, Alter DA, Curtis JP, Rathore SS, Stukel TA, Masoudi FA, Ross JS, Foody JM, Krumholz HM. Regional Variation in Cardiac Catheterization Appropriateness and Baseline Risk After Acute Myocardial Infarction. Journal Of The American College Of Cardiology 2008, 51: 716-723. PMID: 18279735, DOI: 10.1016/j.jacc.2007.10.039.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac catheterization useBaseline riskCardiac catheterizationMyocardial infarctionCardiology/American Heart Association classificationRisk-standardized mortality ratesAmerican Heart Association classificationCardiac catheterization ratesGRACE risk scoreHigh-risk patientsClass I patientsClass III patientsClass II patientsPatient appropriatenessCatheterization ratesHospital admissionI patientsPrimary outcomeAMI patientsII patientsIII patientsAppropriate indicationsInvasive strategyPhysician characteristics
2002
Cardiogenic shock complicating acute myocardial infarction in elderly patients: Does admission to a tertiary center improve survival?
Berger AK, Radford MJ, Krumholz HM. Cardiogenic shock complicating acute myocardial infarction in elderly patients: Does admission to a tertiary center improve survival? American Heart Journal 2002, 143: 768-776. PMID: 12040336, DOI: 10.1067/mhj.2002.122289.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiogenic shockMyocardial infarctionRevascularization servicesCoronary revascularizationPrognosis of patientsCommunity-based cohortCooperative Cardiovascular Project databaseCardiovascular resourcesEarly revascularizationIndex hospitalizationClinical characteristicsElderly patientsCoronary angioplastyTertiary centerBetter prognosisRevascularization capabilityInvasive strategyClinical trialsTreatment strategiesSurgery facilitiesInfarctionPatientsHospitalEarly benefits