2010
Automated External Defibrillators and Survival After In-Hospital Cardiac Arrest
Chan PS, Krumholz HM, Spertus JA, Jones PG, Cram P, Berg RA, Peberdy MA, Nadkarni V, Mancini ME, Nallamothu BK, Investigators F. Automated External Defibrillators and Survival After In-Hospital Cardiac Arrest. JAMA 2010, 304: 2129-2136. PMID: 21078809, PMCID: PMC3587791, DOI: 10.1001/jama.2010.1576.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestAED useHospital dischargeHospitalized patientsShockable rhythmNonshockable rhythmsIn-Hospital Cardiac ArrestMultivariable hierarchical regressionGeneral hospital wardsEntire study populationExternal defibrillatorsPropensity score analysisUse of AEDsCohort studyImproved survivalPatient factorsStudy populationMAIN OUTCOMEPatientsHospital wardsUS hospitalsHospital sitesHospital unitsAEDs
2009
Hospital Variation in Time to Defibrillation After In-Hospital Cardiac Arrest
Chan PS, Nichol G, Krumholz HM, Spertus JA, Nallamothu BK. Hospital Variation in Time to Defibrillation After In-Hospital Cardiac Arrest. JAMA Internal Medicine 2009, 169: 1265-1273. PMID: 19636027, DOI: 10.1001/archinternmed.2009.196.Peer-Reviewed Original ResearchConceptsCardiac arrestHospital factorsHospital variationIn-Hospital Cardiac ArrestHospital-level effectsHospital cardiac arrestWorse survivalImproved survivalPatient factorsAdult inpatientsHospital predictorsNational registryHospital ratesCardiopulmonary resuscitationGreater oddsIdentical covariatesDefibrillation delaysHospitalDefibrillationDefibrillation timeSurvivalArrestWide variationPatientsInpatientsGlucose Normalization and Outcomes in Patients With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Krumholz HM, Masoudi FA, Goyal A, Xiao L, Jones PG, Fiske S, Spertus JA. Glucose Normalization and Outcomes in Patients With Acute Myocardial Infarction. JAMA Internal Medicine 2009, 169: 438-446. PMID: 19273773, DOI: 10.1001/archinternmed.2008.593.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionInsulin therapyMyocardial infarctionGlucose levelsGlucose normalizationBetter survivalElevated blood glucose levelsMultivariable logistic regression modelPropensity-matched analysisMean glucose levelBlood glucose levelsPropensity-matching methodsLow glucose levelsLogistic regression modelsHospital mortalityMultivariable adjustmentImproved survivalHyperglycemic patientsSpontaneous resolutionPatientsMortality rateUS hospitalsAdmissionInfarctionTherapy
1997
Quality of Care, Process, and Outcomes in Elderly Patients With Pneumonia
Meehan TP, Fine MJ, Krumholz HM, Scinto JD, Galusha DH, Mockalis JT, Weber GF, Petrillo MK, Houck PM, Fine JM. Quality of Care, Process, and Outcomes in Elderly Patients With Pneumonia. JAMA 1997, 278: 2080-2084. PMID: 9403422, DOI: 10.1001/jama.1997.03550230056037.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Bacterial AgentsBlood Specimen CollectionCenters for Medicare and Medicaid Services, U.S.FemaleHospital MortalityHumansLogistic ModelsMaleMedicareOutcome and Process Assessment, Health CarePneumoniaQuality Indicators, Health CareRetrospective StudiesSeverity of Illness IndexSurvival AnalysisUnited StatesConceptsBlood culture collectionProcess of careHospital arrivalElderly patientsAntibiotic administrationQuality of careBlood culturesMulticenter retrospective cohort studyOxygenation assessmentInitial antibiotic administrationRetrospective cohort studyCare performanceMedical record reviewHours of arrivalAcute care hospitalsLogistic regression analysisCohort studyCare hospitalImproved survivalRecord reviewHospital careMedicare patientsFrequent causePneumoniaPatients
1995
Sex differences in mortality after myocardial infarction. Is there evidence for an increased risk for women?
Vaccarino V, Krumholz H, Berkman L, Horwitz R. Sex differences in mortality after myocardial infarction. Is there evidence for an increased risk for women? Circulation 1995, 91: 1861-71. PMID: 7882498, DOI: 10.1161/01.cir.91.6.1861.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMortality rateIncreased early mortalitySex differencesUnadjusted mortality ratesHigh mortality rateEnglish-language literatureEarly phaseImproved survivalPatient seriesEarly mortalityFemale sexRisk factorsOutcome eventsCrude rateMEDLINE searchInfarctionSurvival rateOlder ageMortalityWomenAgeMenNumber of studiesLower survival