2020
Quality of Care for Patients Hospitalized for Heart Failure in China
Gupta A, Yu Y, Tan Q, Liu S, Masoudi FA, Du X, Zhang J, Krumholz HM, Li J. Quality of Care for Patients Hospitalized for Heart Failure in China. JAMA Network Open 2020, 3: e1918619. PMID: 31913489, PMCID: PMC6991250, DOI: 10.1001/jamanetworkopen.2019.18619.Peer-Reviewed Original ResearchConceptsQuality of careHospital levelHF careEligible patientsComposite performance scoreEvidence-based β-blockersAngiotensin-converting enzyme inhibitorRetrospective cross-sectional studyVentricular ejection fraction assessmentMedian rateAngiotensin receptor blockersMedian patient ageHeart failure epidemicCross-sectional studyEjection fraction assessmentMedian odds ratioPerformance scoresHF hospitalizationReceptor blockersPatient ageHeart failureHospital admissionMedical recordsOdds ratioMAIN OUTCOME
2019
Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction
Angraal S, Mortazavi BJ, Gupta A, Khera R, Ahmad T, Desai NR, Jacoby DL, Masoudi FA, Spertus JA, Krumholz HM. Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction. JACC Heart Failure 2019, 8: 12-21. PMID: 31606361, DOI: 10.1016/j.jchf.2019.06.013.Peer-Reviewed Original ResearchConceptsHF hospitalizationRisk of mortalityEjection fractionBlood urea nitrogen levelsLogistic regressionPrevious HF hospitalizationHeart failure hospitalizationReduced ejection fractionReceiver-operating characteristic curveRisk of deathBody mass indexBlood urea nitrogenUrea nitrogen levelsHealth status dataMean c-statisticKCCQ scoresTOPCAT trialFailure hospitalizationHeart failureHemoglobin levelsMass indexC-statisticHospitalizationUrea nitrogenMortalityP415330-Day readmission after hospitalization for heart failure in china
Li J, Bai X, Zhang L, Masoudi F, Spertus J, Krumholz H. P415330-Day readmission after hospitalization for heart failure in china. European Heart Journal 2019, 40: ehz745.0725. DOI: 10.1093/eurheartj/ehz745.0725.Peer-Reviewed Original ResearchDays of dischargeHeart failurePatient characteristicsMedian odds ratioOdds ratioChronic obstructive pulmonary diseaseIndex hospital stayObstructive pulmonary diseaseWeeks of dischargeValvular heart diseaseTransitions of careHF hospitalizationRandom hospitalsCause readmissionEligible patientsHospital stayHospitalization stayReadmission diagnosesReadmission ratesConsecutive patientsHospital readmissionMedian agePulmonary diseasePatient factorsC-statistic
2016
Treatment for Multiple Acute Cardiopulmonary Conditions in Older Adults Hospitalized with Pneumonia, Chronic Obstructive Pulmonary Disease, or Heart Failure
Dharmarajan K, Strait KM, Tinetti ME, Lagu T, Lindenauer PK, Lynn J, Krukas MR, Ernst FR, Li SX, Krumholz HM. Treatment for Multiple Acute Cardiopulmonary Conditions in Older Adults Hospitalized with Pneumonia, Chronic Obstructive Pulmonary Disease, or Heart Failure. Journal Of The American Geriatrics Society 2016, 64: 1574-1582. PMID: 27448329, PMCID: PMC4988873, DOI: 10.1111/jgs.14303.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAgedAged, 80 and overAnti-Bacterial AgentsCardiotonic AgentsCohort StudiesComorbidityCross-Sectional StudiesDiureticsDrug Therapy, CombinationFemaleHeart FailureHospitalizationHumansMalePneumoniaPulmonary Disease, Chronic ObstructiveRetrospective StudiesUnited StatesVasodilator AgentsConceptsChronic obstructive pulmonary diseaseAcute cardiopulmonary conditionsObstructive pulmonary diseaseHeart failureCardiopulmonary conditionsOlder adultsPulmonary diseasePremier Research DatabaseEpisodes of pneumoniaRetrospective cohort studyReal-world treatmentHF hospitalizationCohort studyHospital daysPneumonia hospitalizationsCOPD hospitalizationsClinical syndromeAcute conditionsPneumoniaDiagnostic uncertaintyResearch DatabaseHospitalizationDiagnostic categoriesU.S. hospitalsAdults
2015
Racial Differences in Heart Failure Outcomes Evidence From the Tele-HF Trial (Telemonitoring to Improve Heart Failure Outcomes)
Qian F, Parzynski CS, Chaudhry SI, Hannan EL, Shaw BA, Spertus JA, Krumholz HM. Racial Differences in Heart Failure Outcomes Evidence From the Tele-HF Trial (Telemonitoring to Improve Heart Failure Outcomes). JACC Heart Failure 2015, 3: 531-538. PMID: 26160368, PMCID: PMC8635169, DOI: 10.1016/j.jchf.2015.03.005.Peer-Reviewed Original ResearchConceptsPatient-reported health statusKansas City Cardiomyopathy QuestionnaireHeart failureBlack patientsHealth statusHF hospitalizationRacial differencesBaseline KCCQ scoresClinical laboratory valuesPatient-reported outcomesSignificant racial differencesKCCQ scoresHF admissionsPatient demographicsWhite patientsLaboratory valuesPropensity score methodsPatientsHospitalizationOutcome evidenceMonthsLinear mixed modelsBaselineTrialsStatus
2013
National Trends in Heart Failure Hospitalization After Acute Myocardial Infarction for Medicare Beneficiaries
Chen J, Hsieh AF, Dharmarajan K, Masoudi FA, Krumholz HM. National Trends in Heart Failure Hospitalization After Acute Myocardial Infarction for Medicare Beneficiaries. Circulation 2013, 128: 2577-2584. PMID: 24190958, PMCID: PMC4415510, DOI: 10.1161/circulationaha.113.003668.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHF hospitalizationHeart failureMyocardial infarctionMedicare beneficiariesManagement of AMIHeart failure hospitalizationSubsequent HF hospitalizationNumber of patientsNational trendsHigh-risk conditionsContemporary national trendsRelative annual increaseDemographic factorsFailure hospitalizationPerson yearsClinical comorbiditiesNational sampleComplete national sampleHospitalizationMedicare feeAMI hospitalizationService beneficiariesAnnual declineStudy periodDiagnoses and Timing of 30-Day Readmissions After Hospitalization for Heart Failure, Acute Myocardial Infarction, or Pneumonia
Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, Barreto-Filho JA, Kim N, Bernheim SM, Suter LG, Drye EE, Krumholz HM. Diagnoses and Timing of 30-Day Readmissions After Hospitalization for Heart Failure, Acute Myocardial Infarction, or Pneumonia. JAMA 2013, 309: 355-363. PMID: 23340637, PMCID: PMC3688083, DOI: 10.1001/jama.2012.216476.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCommon readmission diagnosesAcute MI hospitalizationReadmission diagnosesDays of hospitalizationPatient demographic characteristicsHeart failureMyocardial infarctionHF hospitalizationReadmission timingPneumonia hospitalizationsMedian timeMI hospitalizationMedicare feeIndex HF hospitalizationIndex pneumonia hospitalizationProportion of patientsDemographic characteristicsService claims dataMI cohortPneumonia cohortHF cohortCondition categoriesHospitalizationReadmission
2012
Procedure Intensity and the Cost of Care
Chen SI, Dharmarajan K, Kim N, Strait KM, Li SX, Safavi KC, Lindenauer PK, Krumholz HM, Lagu T. Procedure Intensity and the Cost of Care. Circulation Cardiovascular Quality And Outcomes 2012, 5: 308-313. PMID: 22576844, PMCID: PMC3415230, DOI: 10.1161/circoutcomes.112.966069.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCosts and Cost AnalysisCross-Sectional StudiesFemaleHeart FailureHospital Bed CapacityHospital CostsHospital MortalityHospitalizationHospitals, RuralHospitals, TeachingHospitals, UrbanHumansLength of StayLinear ModelsMaleMiddle AgedModels, EconomicOutcome and Process Assessment, Health CareResidence CharacteristicsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsHF hospitalizationHeart failureInvasive proceduresHospital groupRisk-standardized mortality ratesProportion of patientsLength of stayCost of careWilcoxon rank sum testHigher procedure ratesRank sum testPatient demographicsPerspective databaseMedian lengthSurgical proceduresProcedure ratesHospitalizationOutcome differencesMortality rateHospitalPatientsPractice styleProcedure useSum testOverall use
2011
National and Regional Trends in Heart Failure Hospitalization and Mortality Rates for Medicare Beneficiaries, 1998-2008
Chen J, Normand SL, Wang Y, Krumholz HM. National and Regional Trends in Heart Failure Hospitalization and Mortality Rates for Medicare Beneficiaries, 1998-2008. JAMA 2011, 306: 1669-1678. PMID: 22009099, PMCID: PMC3688069, DOI: 10.1001/jama.2011.1474.Peer-Reviewed Original ResearchConceptsHF hospitalization ratesHeart failure hospitalizationHospitalization ratesMortality rateFailure hospitalizationHeart failure hospitalization ratesPrincipal discharge diagnosis codeOne-year mortality rateDischarge diagnosis codesIschemic heart diseaseAcute care hospitalsService Medicare beneficiariesLower ratesBlack menHF hospitalizationPatient demographicsCare hospitalDiagnosis codesHeart diseaseRisk factorsMedicare beneficiariesHospitalizationStudy periodMortalityNational mean
2008
Statistical Models and Patient Predictors of Readmission for Heart Failure: A Systematic Review
Ross JS, Mulvey GK, Stauffer B, Patlolla V, Bernheim SM, Keenan PS, Krumholz HM. Statistical Models and Patient Predictors of Readmission for Heart Failure: A Systematic Review. JAMA Internal Medicine 2008, 168: 1371-1386. PMID: 18625917, DOI: 10.1001/archinte.168.13.1371.Peer-Reviewed Original ResearchMeSH KeywordsDisease ProgressionEvidence-Based MedicineFemaleHeart FailureHospitalizationHumansIncidenceMaleModels, StatisticalPatient ReadmissionPredictive Value of TestsProportional Hazards ModelsQuality-Adjusted Life YearsRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSurvival AnalysisUnited StatesConceptsPatient characteristicsPatient readmission riskReadmission riskPatient riskSystematic reviewReadmission ratesHospital ratesOvid Evidence-Based Medicine ReviewsEligible English-language publicationsEvidence-Based Medicine ReviewsHeart failure hospitalizationPatient risk stratificationEnglish-language literatureEnglish-language publicationsFailure hospitalizationHF hospitalizationAdult patientsHeart failureHospital readmissionMedicine ReviewsRisk stratificationPatient predictorsInclusion criteriaReadmissionCombined outcome
2006
Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death
Heidenreich PA, Spertus JA, Jones PG, Weintraub WS, Rumsfeld JS, Rathore SS, Peterson ED, Masoudi FA, Krumholz HM, Havranek EP, Conard MW, Williams RE, Consortium C. Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death. Journal Of The American College Of Cardiology 2006, 47: 752-756. PMID: 16487840, DOI: 10.1016/j.jacc.2005.11.021.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireB-type natriuretic peptideKCCQ summary scoreHeart failureKCCQ scoresHealth status measuresClinical conditionsNew York Heart Association functional class IVSummary scoresStatus measuresFunctional class IVIschemic HF etiologyLower KCCQ scoresSequential multivariable modelsBaseline patient characteristicsHeart failure outpatientsPatient's clinical conditionProportional hazards regressionBNP levelsHF etiologyHF hospitalizationHF admissionsHF patientsPatient characteristicsWalk distance
2005
Low-to-Moderate Alcohol Intake and Health Status in Heart Failure Patients
Salisbury AC, House JA, Conard MW, Krumholz HM, Spertus JA. Low-to-Moderate Alcohol Intake and Health Status in Heart Failure Patients. Journal Of Cardiac Failure 2005, 11: 323-328. PMID: 15948080, DOI: 10.1016/j.cardfail.2004.11.009.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireModerate alcohol intakeHealth statusHF hospitalizationAlcohol intakeAlcohol abstinenceBaseline Kansas City Cardiomyopathy QuestionnaireShort Form-12 scoresComplete alcohol abstinenceHeart failure guidelinesMulticenter observational studyHeart failure patientsModerate alcohol consumptionSF-12 scoresKCCQ scoresHF outpatientsHF patientsFailure patientsMultivariable analysisBaseline differencesObservational studyModerate drinkersAlcohol consumptionSimilar outcomesAlcohol use
2004
Adverse Effects of β-Blocker Therapy for Patients With Heart Failure: A Quantitative Overview of Randomized Trials
Ko DT, Hebert PR, Coffey CS, Curtis JP, Foody JM, Sedrakyan A, Krumholz HM. Adverse Effects of β-Blocker Therapy for Patients With Heart Failure: A Quantitative Overview of Randomized Trials. JAMA Internal Medicine 2004, 164: 1389-1394. PMID: 15249347, DOI: 10.1001/archinte.164.13.1389.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedBisoprololBradycardiaCarbazolesCarvedilolDizzinessFatigueFemaleFollow-Up StudiesHeart Conduction SystemHeart FailureHumansHypotensionMaleMetoprololMiddle AgedPropanolaminesRisk FactorsRisk Reduction BehaviorSeverity of Illness IndexStatistics as TopicTreatment FailureVentricular Dysfunction, LeftWithholding TreatmentConceptsBeta-blocker therapyHeart failureAdverse effectsLeft ventricular systolic dysfunctionBeta-blocker trialsCardiovascular adverse effectsChronic heart failureHeart Failure TrialVentricular systolic dysfunctionΒ-blocker therapyRisk of hypotensionLife-saving therapyRandom-effects modelHF hospitalizationCause mortalitySystolic dysfunctionCause withdrawalsFailure TrialRandomized trialsAbsolute riskElectronic searchPatientsMEDLINE databaseTherapyAbsolute increase