2013
HbA1c and Risk of Severe Hypoglycemia in Type 2 Diabetes
Lipska KJ, Warton EM, Huang ES, Moffet HH, Inzucchi SE, Krumholz HM, Karter AJ. HbA1c and Risk of Severe Hypoglycemia in Type 2 Diabetes. Diabetes Care 2013, 36: 3535-3542. PMID: 23900589, PMCID: PMC3816866, DOI: 10.2337/dc13-0610.Peer-Reviewed Original ResearchConceptsSevere hypoglycemiaType 2 diabetesRelative riskGlycemic controlSelf-reported severe hypoglycemiaType 2 diabetic patientsGlucose-lowering therapyPoor glycemic controlRate of hypoglycemiaPotential effect modifiersIntegrated healthcare systemYears of ageEligible survey respondentsPoisson regression modelsDiabetes durationDiabetes medicationsDiabetic patientsClinical variablesDiabetes StudyNormal glycemiaMain exposureEffect modifiersHypoglycemiaType 2Patients
2010
Discontinuation of Antihyperglycemic Therapy and Clinical Outcomes After Acute Myocardial Infarction in Older Patients With Diabetes
Lipska KJ, Wang Y, Kosiborod M, Masoudi FA, Havranek EP, Krumholz HM, Inzucchi SE. Discontinuation of Antihyperglycemic Therapy and Clinical Outcomes After Acute Myocardial Infarction in Older Patients With Diabetes. Circulation Cardiovascular Quality And Outcomes 2010, 3: 236-242. PMID: 20354220, DOI: 10.1161/circoutcomes.109.887620.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAntihyperglycemic therapyAntihyperglycemic agentsOlder patientsMyocardial infarctionMortality rateMultivariable Cox proportional hazards modelsCox proportional hazards modelFrequency of discontinuationGlucose-lowering agentsGlucose-lowering therapyInclusion/exclusion criteriaProportional hazards modelYear of dischargeHigh mortality rateDiabetic regimenFirst rehospitalizationReadmission ratesSecondary outcomesHeart failurePrimary outcomeClinical outcomesMultivariable analysisRetrospective studyIndependent association
2009
Relationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Goyal A, Krumholz HM, Masoudi FA, Xiao L, Spertus JA. Relationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction. JAMA 2009, 301: 1556-1564. PMID: 19366775, DOI: 10.1001/jama.2009.496.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionInsulin therapyHospital mortalityIatrogenic hypoglycemiaHypoglycemic eventsMyocardial infarctionMortality riskGlucose-lowering therapyRetrospective cohort studySubgroup of patientsHigher mortality riskLogistic regression modelsMore comorbiditiesSubsequent hospitalizationMultivariable adjustmentCohort studyGlucose loweringGlucose controlEpisodic hypoglycemiaMAIN OUTCOMEHypoglycemiaPatientsHealth FactsHigh mortalityTherapy