2020
Presentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study
Gupta A, Tsang S, Hajduk A, Krumholz HM, Nanna MG, Green P, Dodson JA, Chaudhry SI. Presentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2020, 134: 95-103. PMID: 32805225, PMCID: PMC7752813, DOI: 10.1016/j.amjmed.2020.07.020.Peer-Reviewed Original ResearchConceptsOldest-old patientsMyocardial infarctionFunctional impairmentOlder patientsMobility impairmentsCox proportional hazards regressionMiddle-old patientsProportional hazards regressionAcute myocardial infarctionCase fatality rateAcute myocardial infarction hospitalizationsSILVER-AMI StudyYears of ageMyocardial infarction hospitalizationsChest painCoronary revascularizationAtypical presentationHazards regressionClinical variablesRisk factorsAdvanced agePrimary symptomsPatientsFatality rateHealth status
2019
Disparities in Socioeconomic Context and Association With Blood Pressure Control and Cardiovascular Outcomes in ALLHAT
Shahu A, Herrin J, Dhruva SS, Desai NR, Davis BR, Krumholz HM, Spatz ES. Disparities in Socioeconomic Context and Association With Blood Pressure Control and Cardiovascular Outcomes in ALLHAT. Journal Of The American Heart Association 2019, 8: e012277. PMID: 31362591, PMCID: PMC6761647, DOI: 10.1161/jaha.119.012277.Peer-Reviewed Original ResearchConceptsBlood pressure controlLow-income sitesCardiovascular outcomesPressure controlALLHAT participantsPoor blood pressure controlEnd-stage renal diseaseHospitalization/mortalityAdverse cardiovascular eventsCardiovascular risk factorsWorse cardiovascular outcomesHigh blood pressureStandardized treatment protocolRandomized clinical trialsBackground Observational studiesLow socioeconomic statusHighest income quintileAngina hospitalizationCardiovascular eventsCause mortalityCoronary revascularizationClinical characteristicsBlood pressureRenal diseaseClinical outcomes
2018
Comparison of Physician Visual Assessment With Quantitative Coronary Angiography in Assessment of Stenosis Severity in China
Zhang H, Mu L, Hu S, Nallamothu BK, Lansky AJ, Xu B, Bouras G, Cohen DJ, Spertus JA, Masoudi FA, Curtis JP, Gao R, Ge J, Yang Y, Li J, Li X, Zheng X, Li Y, Krumholz HM, Jiang L. Comparison of Physician Visual Assessment With Quantitative Coronary Angiography in Assessment of Stenosis Severity in China. JAMA Internal Medicine 2018, 178: 239-247. PMID: 29340571, PMCID: PMC5838612, DOI: 10.1001/jamainternmed.2017.7821.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChinaCoronary AngiographyCoronary StenosisCoronary VesselsCross-Sectional StudiesFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPractice Patterns, Physicians'Predictive Value of TestsProspective StudiesRisk AssessmentSeverity of Illness IndexTime FactorsConceptsPhysician visual assessmentPercutaneous coronary interventionAcute myocardial infarctionQuantitative coronary angiographyStenosis severityCoronary angiographyMean agePCI studiesMean percent diameter stenosisIndependent core laboratoryPercent diameter stenosisCross-sectional studyNon-AMI patientsStandard clinical practiceFractional flow reserveSubset of participantsQCA assessmentCoronary revascularizationMore stenosisCoronary interventionCoronary lesionsChina PatientCoronary angiogramDiameter stenosisMyocardial infarction
2015
Appropriate Use Criteria for Coronary Revascularization and Trends in Utilization, Patient Selection, and Appropriateness of Percutaneous Coronary Intervention
Desai NR, Bradley SM, Parzynski CS, Nallamothu BK, Chan PS, Spertus JA, Patel MR, Ader J, Soufer A, Krumholz HM, Curtis JP. Appropriate Use Criteria for Coronary Revascularization and Trends in Utilization, Patient Selection, and Appropriateness of Percutaneous Coronary Intervention. JAMA 2015, 314: 2045-2053. PMID: 26551163, PMCID: PMC5459470, DOI: 10.1001/jama.2015.13764.Peer-Reviewed Original ResearchConceptsNonacute percutaneous coronary interventionPercutaneous coronary interventionAppropriate use criteriaInappropriate percutaneous coronary interventionHospital-level variationCoronary revascularizationPatient selectionUse criteriaCoronary interventionStudy periodAppropriateness of PCINational Cardiovascular Data Registry CathPCI RegistryProportion of PCIsMultivessel coronary artery diseaseHigh-risk findingsCoronary artery diseaseAnnual PCI volumesCross-sectional analysisAngina severityAntianginal medicationsAcute indicationsCathPCI RegistryArtery diseasePCI volumePCI procedures
2011
Statin Use in Outpatients With Obstructive Coronary Artery Disease
Arnold SV, Spertus JA, Tang F, Krumholz HM, Borden WB, Farmer SA, Ting HH, Chan PS. Statin Use in Outpatients With Obstructive Coronary Artery Disease. Circulation 2011, 124: 2405-2410. PMID: 22064595, PMCID: PMC3527107, DOI: 10.1161/circulationaha.111.038265.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArterial Occlusive DiseasesCardiovascular DiseasesCholesterol, LDLCoronary Artery DiseaseFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedOutpatientsPractice Guidelines as TopicProspective StudiesRegistriesRetrospective StudiesRisk FactorsTreatment OutcomeConceptsObstructive coronary artery diseaseLow-density lipoprotein cholesterol levelsCoronary artery diseaseLipoprotein cholesterol levelsLipid-lowering therapyCholesterol levelsStatin therapyUntreated patientsStatin treatmentArtery diseaseLow-density lipoprotein cholesterol valuesNonstatin lipid-lowering medicationsRobust clinical trial evidenceRecent coronary revascularizationClinical trial evidenceLipid-lowering medicationsRoutine outpatient careLipoprotein cholesterol valuesRate of treatmentNonstatin medicationsNonstatin therapiesOutpatient registryCardiovascular morbidityCoronary revascularizationLipid management
2007
Opening of Specialty Cardiac Hospitals and Use of Coronary Revascularization in Medicare Beneficiaries
Nallamothu BK, Rogers MA, Chernew ME, Krumholz HM, Eagle KA, Birkmeyer JD. Opening of Specialty Cardiac Hospitals and Use of Coronary Revascularization in Medicare Beneficiaries. JAMA 2007, 297: 962-968. PMID: 17341710, DOI: 10.1001/jama.297.9.962.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCardiac Care FacilitiesCardiology Service, HospitalCatchment Area, HealthCoronary Artery BypassHealth Care SurveysHealth Services Needs and DemandHospitals, GeneralHumansLinear ModelsMedicareMyocardial RevascularizationPractice Patterns, Physicians'Program DevelopmentReimbursement, IncentiveUnited StatesUtilization ReviewConceptsHospital referral regionsPopulation-based ratesSpecialty cardiac hospitalsCardiac hospitalTotal revascularizationCoronary revascularizationGeneral HospitalMedicare beneficiariesCardiac programAnnual population-based ratesAcute myocardial infarctionCost-efficient careMyocardial infarctionAdjusted ratesRevascularizationReferral regionsProcedure utilizationHospitalCABGPCIPatientsLinear regression modelsRegression modelsRelative increaseHealth care marketDoes Health Status Differ between Men And Women in Early Recovery after Myocardial Infarction
Garavalia LS, Decker C, Reid KJ, Lichtman JH, Parashar S, Vaccarino V, Krumholz HM, Spertus JA. Does Health Status Differ between Men And Women in Early Recovery after Myocardial Infarction. Journal Of Women's Health 2007, 16: 93-101. PMID: 17324100, DOI: 10.1089/jwh.2006.m073.Peer-Reviewed Original ResearchConceptsMyocardial infarctionHealth statusNon-ST segment elevation myocardial infarctionRisk-adjusted multivariable modelsSegment elevation myocardial infarctionChronic lung diseaseElevation myocardial infarctionWorse health statusPoor physical functioningQuality of lifeResidual anginaCoronary revascularizationHeart failureLung diseaseMI patientsPhysical functionMultivariable PoissonMultivariable modelPhysical functioningEarly recoveryGreater prevalenceInfarctionPatientsAdditional treatmentWomen
2004
Regional variations in racial differences in the treatment of elderly patients hospitalized with acute myocardial infarction
Rathore SS, Masoudi FA, Havranek EP, Krumholz HM. Regional variations in racial differences in the treatment of elderly patients hospitalized with acute myocardial infarction. The American Journal Of Medicine 2004, 117: 811-822. PMID: 15589484, PMCID: PMC2790535, DOI: 10.1016/j.amjmed.2004.06.034.Peer-Reviewed Original ResearchConceptsBeta-blocker useMyocardial infarctionWhite patientsCoronary revascularizationBlack patientsRacial differencesCardiac catheterization useLower crude ratesUse of aspirinDay of admissionHealth care useTreatment of patientsAcute myocardial infarctionService Medicare beneficiariesMedical record dataQuality of careElderly feeRevascularization useAspirin useMultivariable adjustmentElderly patientsCardiac catheterizationCardiac proceduresCare useCrude rate
2003
Sex Differences in Use of Coronary Revascularization in Elderly Patients After Acute Myocardial Infarction A Tale of Two Therapies
Rathore SS, Foody JM, Radford MJ, Krumholz HM. Sex Differences in Use of Coronary Revascularization in Elderly Patients After Acute Myocardial Infarction A Tale of Two Therapies. CHEST Journal 2003, 124: 2079-2086. PMID: 14665483, DOI: 10.1378/chest.124.6.2079.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRisk-standardized ratesPercutaneous coronary interventionCoronary revascularizationElderly patientsCardiac catheterizationRevascularization therapyMedicare patientsCoronary artery bypass graft surgeryArtery bypass graft surgerySex differencesMultivariable logistic regression modelCrude overall ratesBypass graft surgeryCoronary revascularization ratesType of therapyMedical record dataLogistic regression modelsRevascularization useCABG surgeryGraft surgeryMultivariable adjustmentRevascularization ratesCoronary interventionHospital admission
2002
Cardiogenic shock complicating acute myocardial infarction in elderly patients: Does admission to a tertiary center improve survival?
Berger AK, Radford MJ, Krumholz HM. Cardiogenic shock complicating acute myocardial infarction in elderly patients: Does admission to a tertiary center improve survival? American Heart Journal 2002, 143: 768-776. PMID: 12040336, DOI: 10.1067/mhj.2002.122289.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiogenic shockMyocardial infarctionRevascularization servicesCoronary revascularizationPrognosis of patientsCommunity-based cohortCooperative Cardiovascular Project databaseCardiovascular resourcesEarly revascularizationIndex hospitalizationClinical characteristicsElderly patientsCoronary angioplastyTertiary centerBetter prognosisRevascularization capabilityInvasive strategyClinical trialsTreatment strategiesSurgery facilitiesInfarctionPatientsHospitalEarly benefits
2000
Impact of Smoking on Health-Related Quality of Life After Percutaneous Coronary Revascularization
Taira D, Seto T, Ho K, Krumholz H, Cutlip D, Berezin R, Kuntz R, Cohen D. Impact of Smoking on Health-Related Quality of Life After Percutaneous Coronary Revascularization. Circulation 2000, 102: 1369-1374. PMID: 10993854, DOI: 10.1161/01.cir.102.12.1369.Peer-Reviewed Original ResearchConceptsGeneral health perceptionSmoking statusHealth perceptionMedical Outcomes Study SF-36 questionnaireSymptomatic coronary artery diseaseMental healthRole-physical functioningImpact of smokingLate myocardial infarctionHealth-related qualityPercutaneous coronary revascularizationSF-36 questionnaireCoronary artery diseaseMulticenter clinical trialTime of PTCAQuality of lifeHRQoL improvementContinued smokingCoronary revascularizationBaseline characteristicsArtery diseaseIndex procedureSmoking cessationPhysical functionMyocardial infarctionPerceptions of Benefit and Risk of Patients Undergoing First‐time Elective Percutaneous Coronary Revascularization
Holmboe E, Fiellin D, Cusanelli E, Remetz M, Krumholz H. Perceptions of Benefit and Risk of Patients Undergoing First‐time Elective Percutaneous Coronary Revascularization. Journal Of General Internal Medicine 2000, 15: 632-637. PMID: 11029677, PMCID: PMC1495592, DOI: 10.1046/j.1525-1497.2000.90823.x.Peer-Reviewed Original ResearchConceptsElective percutaneous coronary revascularizationPercutaneous coronary revascularizationMajority of patientsCoronary revascularizationAbnormal diagnostic test resultsFuture myocardial infarctionRelief of symptomsRisk of patientsDiagnostic test resultsConsecutive patientsMean ageMyocardial infarctionLong-term benefitsPossible complicationsPotential complicationsPatient decisionPatient expectationsPatientsSemistructured questionnaireRevascularizationComplicationsRiskPerceptions of benefitsPotential riskQuestionnaireAre β-Blockers Effective in Elderly Patients Who Undergo Coronary Revascularization After Acute Myocardial Infarction?
Chen J, Radford MJ, Wang Y, Marciniak TA, Krumholz HM. Are β-Blockers Effective in Elderly Patients Who Undergo Coronary Revascularization After Acute Myocardial Infarction? JAMA Internal Medicine 2000, 160: 947-952. PMID: 10761959, DOI: 10.1001/archinte.160.7.947.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryPercutaneous transluminal coronary angioplastyBeta-blocker therapyAcute myocardial infarctionNonrevascularized groupCoronary revascularizationElderly patientsMyocardial infarctionNon-revascularized groupArtery bypass surgeryTransluminal coronary angioplastyClinical practice guidelinesCooperative Cardiovascular ProjectRandomized clinical trialsAmerican Heart AssociationBypass surgerySuccessful revascularizationClinical factorsCoronary angioplastyHeart AssociationPotential confoundersClinical trialsPractice guidelinesRevascularizationAmerican College
1996
Changes in health after elective percutaneous coronary revascularization. A comparison of generic and specific measures.
Krumholz HM, McHorney CA, Clark L, Levesque M, Baim DS, Goldman L. Changes in health after elective percutaneous coronary revascularization. A comparison of generic and specific measures. Medical Care 1996, 34: 754-9. PMID: 8709657, DOI: 10.1097/00005650-199608000-00003.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAngioplasty, Balloon, CoronaryBostonElective Surgical ProceduresFemaleHealth StatusHealth SurveysHumansMaleMental HealthMiddle AgedOutcome Assessment, Health CareProspective StudiesQuality of LifeReproducibility of ResultsSick RoleSurveys and QuestionnairesTime FactorsConceptsElective percutaneous coronary revascularizationCanadian Cardiovascular Society classificationPercutaneous coronary revascularizationHealth-related qualityCoronary revascularizationSpecific Activity ScaleRole limitationsElective percutaneous transluminal coronary angioplastyPercutaneous transluminal coronary angioplastyForm Health SurveyMedical Outcomes StudyTransluminal coronary angioplastyGeneral health perceptionRole physical scaleSF-36 Role Physical scaleSF-36 physical functioning scaleSF-36 measuresPhysical functioning scaleGeneral mental healthPhysical health problemsEmotional health problemsSymptomatic patientsCoronary angioplastyPhysical functioningSociety classification
1993
Coronary revascularization after myocardial infarction in the very elderly: outcomes and long-term follow-up.
Krumholz HM, Forman DE, Kuntz RE, Baim DS, Wei JY. Coronary revascularization after myocardial infarction in the very elderly: outcomes and long-term follow-up. Annals Of Internal Medicine 1993, 119: 1084-90. PMID: 8239227, DOI: 10.7326/0003-4819-119-11-199312010-00005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationContraindicationsFemaleFollow-Up StudiesHemodynamicsHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationProportional Hazards ModelsQuality of LifeRetrospective StudiesSurvival AnalysisTreatment OutcomeConceptsAcute myocardial infarctionCoronary revascularizationMyocardial infarctionElderly patientsComplicated acute myocardial infarctionConsecutive patients 80 yearsCoronary artery bypass surgeryTertiary care teaching hospitalCox proportional hazards modelMedical therapy groupPatients 80 yearsRetrospective cohort studyArtery bypass surgerySevere valvular diseaseSignificant coronary diseaseInvasive cardiovascular proceduresProportional hazards modelQuality of lifeAngioplasty groupSurgery groupBypass surgeryCohort studyCardiac catheterizationCoronary diseaseSerious complications
1992
Selection of patients for coronary angiography and coronary revascularization early after myocardial infarction: is there evidence for a gender bias?
Krumholz HM, Douglas PS, Lauer MS, Pasternak RC. Selection of patients for coronary angiography and coronary revascularization early after myocardial infarction: is there evidence for a gender bias? Annals Of Internal Medicine 1992, 116: 785-90. PMID: 1567092, DOI: 10.7326/0003-4819-116-10-785.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAngioplasty, Balloon, CoronaryCardiac CatheterizationCoronary AngiographyCoronary Artery BypassFemaleHospitalizationHumansMaleMiddle AgedMyocardial InfarctionMyocardial RevascularizationOdds RatioPatient SelectionPrejudiceReferral and ConsultationRetrospective StudiesSeverity of Illness IndexSex FactorsVentricular Function, LeftConceptsCoronary artery diseaseSelection of patientsMyocardial infarctionCoronary angiographyArtery diseaseCoronary artery bypass graft surgeryArtery bypass graft surgeryCoronary artery bypass surgerySevere coronary artery diseasePercutaneous transluminal coronary angioplastyCreatine kinase MB fractionTertiary care teaching hospitalThree-vessel diseaseTwo-vessel diseaseArtery bypass surgeryBypass graft surgeryLeft main stenosisRetrospective cohort studyTransluminal coronary angioplastyPrincipal discharge diagnosisAcute myocardial infarctionAbnormal ejection fractionAge-adjusted ratesTherapeutic cardiovascular proceduresCoronary revascularization