2007
Adverse Effects of Combination Angiotensin II Receptor Blockers Plus Angiotensin-Converting Enzyme Inhibitors for Left Ventricular Dysfunction: A Quantitative Review of Data From Randomized Clinical Trials
Phillips CO, Kashani A, Ko DK, Francis G, Krumholz HM. Adverse Effects of Combination Angiotensin II Receptor Blockers Plus Angiotensin-Converting Enzyme Inhibitors for Left Ventricular Dysfunction: A Quantitative Review of Data From Randomized Clinical Trials. JAMA Internal Medicine 2007, 167: 1930-1936. PMID: 17923591, DOI: 10.1001/archinte.167.18.1930.Peer-Reviewed Original ResearchConceptsAngiotensin II receptor blockersSymptomatic left ventricular dysfunctionLeft ventricular dysfunctionII receptor blockersVentricular dysfunctionAdverse effectsMedication discontinuationReceptor blockersSymptomatic hypotensionRenal functionACE inhibitorsClinical trialsRelative riskEnzyme inhibitorsAngiotensin converting enzyme (ACE) inhibitorsACE inhibitor therapyHealth clinical trialsChronic heart failureRandomized clinical trialsAcute myocardial infarctionConfidence intervalsRandom-effects modelSignificant increaseEligible RCTsHeart failure
1999
Risk factors for heart failure in the elderly: a prospective community-based study
Chen Y, Vaccarino V, Williams C, Butler J, Berkman L, Krumholz H. Risk factors for heart failure in the elderly: a prospective community-based study. The American Journal Of Medicine 1999, 106: 605-612. PMID: 10378616, DOI: 10.1016/s0002-9343(99)00126-6.Peer-Reviewed Original ResearchConceptsTraditional cardiovascular risk factorsCardiovascular risk factorsHeart failureRisk factorsMyocardial infarctionRisk ratioCommunity-based elderly populationProportional hazards regression modelsProspective community-based studyIncident heart failureBody mass indexHazards regression modelsConfidence intervalsCommunity-based studyManagement of diabetesYears of ageConnecticut cohortChart reviewBlood pressureIndependent predictorsMass indexMale sexElderly ProgramPulse pressurePreventive strategies
1997
Functional Disability Before Myocardial Infarction in the Elderly as a Determinant of Infarction Severity and Postinfarction Mortality
Vaccarino V, Berkman LF, Mendes de Leon CF, Seeman TE, Horwitz RI, Krumholz HM. Functional Disability Before Myocardial Infarction in the Elderly as a Determinant of Infarction Severity and Postinfarction Mortality. JAMA Internal Medicine 1997, 157: 2196-2204. PMID: 9342996, DOI: 10.1001/archinte.1997.00440400046006.Peer-Reviewed Original ResearchConceptsMyocardial infarctionClinical severityFunctional disabilityElderly patientsDaily livingHigh mortalityAcute myocardial infarctionHigher clinical severityMore comorbiditiesPostinfarction mortalityHospital arrivalMI severityInfarction severityHospital treatmentHigh comorbidityRelative riskOutcome measuresCommon conditionPatientsTreatment interventionsMortalityOlder ageSeverity characteristicsSeverityConfidence intervals