2019
Digoxin Use and Associated Adverse Events Among Older Adults
Angraal S, Nuti SV, Masoudi FA, Freeman JV, Murugiah K, Shah ND, Desai NR, Ranasinghe I, Wang Y, Krumholz HM. Digoxin Use and Associated Adverse Events Among Older Adults. The American Journal Of Medicine 2019, 132: 1191-1198. PMID: 31077654, DOI: 10.1016/j.amjmed.2019.04.022.Peer-Reviewed Original ResearchConceptsRate of hospitalizationDigoxin useDigoxin toxicityNational Prescription AuditMedicare feeService beneficiariesDigoxin prescriptionAssociated adverse eventsAdverse eventsCohort studyAdverse outcomesSecondary diagnosisNational cohortPrescription auditPrescription trendsClinical guidelinesHospitalizationMortality rateClinical practiceOlder adultsSubsequent outcomesOutcomesToxicityPrescriptionNational-level trends
2012
Hospital Patterns of Use of Positive Inotropic Agents in Patients With Heart Failure
Partovian C, Gleim SR, Mody PS, Li SX, Wang H, Strait KM, Allen LA, Lagu T, Normand SL, Krumholz HM. Hospital Patterns of Use of Positive Inotropic Agents in Patients With Heart Failure. Journal Of The American College Of Cardiology 2012, 60: 1402-1409. PMID: 22981548, PMCID: PMC3636773, DOI: 10.1016/j.jacc.2012.07.011.Peer-Reviewed Original ResearchConceptsPositive inotropic agentsRisk-standardized ratesInotropic agentsHeart failureInotrope useHospital patternsMortality rateRisk-standardized mortality ratesHospital mortality rateHeart failure patientsLittle clinical evidenceLength of stayPatient case mixHierarchical logistic regression modelsLogistic regression modelsIntraclass correlation coefficientFailure patientsHospital variationClinical evidenceInterhospital variationClinical guidelinesIndividual hospital effectsHospital ratesHospital effectsPatterns of use
2006
Physician Board Certification and the Care and Outcomes of Elderly Patients with Acute Myocardial Infarction
Chen J, Rathore SS, Wang Y, Radford MJ, Krumholz HM. Physician Board Certification and the Care and Outcomes of Elderly Patients with Acute Myocardial Infarction. Journal Of General Internal Medicine 2006, 21: 238-244. PMID: 16637823, PMCID: PMC1828098, DOI: 10.1111/j.1525-1497.2006.00326.x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionBoard-certified physiciansPhysician board certificationMyocardial infarctionFamily practitionersInternal medicineBoard certificationHigher useUse of aspirinQuality of careMultivariate regression analysisBoard-certified internistsElderly patientsHospitalized patientsClinical guidelinesMedicare patientsAspirinPatientsMortalityPhysiciansFamily practiceCareInfarctionRegression analysisCardiologists
2002
Sex differences in cardiac catheterization after acute myocardial infarction: the role of procedure appropriateness.
Rathore SS, Wang Y, Radford MJ, Ordin DL, Krumholz HM. Sex differences in cardiac catheterization after acute myocardial infarction: the role of procedure appropriateness. Annals Of Internal Medicine 2002, 137: 487-93. PMID: 12230349, DOI: 10.7326/0003-4819-137-6-200209170-00008.Peer-Reviewed Original ResearchConceptsCardiac catheterization useAcute myocardial infarctionCardiac catheterizationMyocardial infarctionMultivariable adjustmentEquivocal indicationsSex differencesProcedure useChart-abstracted dataLower crude ratesRisk-standardized ratesU.S. acute care hospitalsDays of hospitalizationAcute care hospitalsClinical guidelinesHospital characteristicsMedicare patientsCrude rateInappropriate treatmentRetrospective analysisCatheterizationInfarctionPatientsElderly personsWomenβ-Blocker Therapy in Heart Failure: Scientific Review
Foody JM, Farrell MH, Krumholz HM. β-Blocker Therapy in Heart Failure: Scientific Review. JAMA 2002, 287: 883-889. PMID: 11851582, DOI: 10.1001/jama.287.7.883.Peer-Reviewed Original ResearchConceptsHeart failure patientsHeart failureClinical trialsFailure patientsClinical outcomesClass IIDrug Administration indicationsBeta-blocker usePrimary end pointΒ-blocker therapyScientific rationaleTreatment of patientsCare of patientsEnglish-language articlesPotential physiologic roleBasic science studiesClass of agentsSystolic dysfunctionMortality benefitPlacebo treatmentDATA EXTRACTIONClinical guidelinesSTUDY SELECTIONCurrent recommendationsPatients
2001
An Evidence-Based Assessment of Federal Guidelines for Overweight and Obesity as They Apply to Elderly Persons
Heiat A, Vaccarino V, Krumholz HM. An Evidence-Based Assessment of Federal Guidelines for Overweight and Obesity as They Apply to Elderly Persons. JAMA Internal Medicine 2001, 161: 1194-1203. PMID: 11343442, DOI: 10.1001/archinte.161.9.1194.Peer-Reviewed Original ResearchConceptsCardiovascular mortalityElderly personsCause mortalityMortality riskCoronary heart disease eventsIdeal weightUS clinical guidelinesHeart disease eventsSignificant prognostic factorsTreatment of overweightBaseline health statusExcess mortality riskRelative mortality riskBody mass indexMiddle-aged populationHigher BMI valuesAdditional pertinent articlesEnglish-language studiesSpecific age groupsPrognostic factorsMass indexSignificant positive associationHealthy weightPrognostic importanceClinical guidelinesCan Practice Guidelines Be Transported Effectively to Different Settings? Results from a Multicenter Interventional Study
Lichtman J, Roumanis S, Radford M, Riedinger M, Weingarten S, Krumholz H. Can Practice Guidelines Be Transported Effectively to Different Settings? Results from a Multicenter Interventional Study. The Joint Commission Journal On Quality And Patient Safety 2001, 27: 42-53. PMID: 11147239, DOI: 10.1016/s1070-3241(01)27005-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedChest PainConnecticutFollow-Up StudiesHealth Care SurveysHospitalizationHumansInterviews as TopicMaleMiddle AgedNebraskaNorth CarolinaOutcome Assessment, Health CarePatient DischargePatient SatisfactionPennsylvaniaPractice Guidelines as TopicProspective StudiesSouth CarolinaSurveys and QuestionnairesConceptsChest painClinical guidelinesIntervention periodGuideline adherenceGuideline implementationPatient outcomesLow-risk chest pain patientsLow-risk chest painStandardized protocolMulticenter interventional studyLow-risk patientsChest pain patientsInterventional trialsPain patientsSuccessful translationClinical outcomesGuideline periodInterventional studyPatient satisfactionPatient's physicianPractice guidelinesHospital settingBaseline valuesClinical practicePain