2024
When Direct Oral Anticoagulants Should Not Be Standard Treatment JACC State-of-the-Art Review
Bejjani A, Khairani C, Assi A, Piazza G, Sadeghipour P, Talasaz A, Fanikos J, Connors J, Siegal D, Barnes G, Martin K, Angiolillo D, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind M, Ruff C, Goldhaber S, Krumholz H, Mehran R, Cushman M, Eikelboom J, Lip G, Weitz J, Lopes R, Bikdeli B. When Direct Oral Anticoagulants Should Not Be Standard Treatment JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2024, 83: 444-465. PMID: 38233019, DOI: 10.1016/j.jacc.2023.10.038.Peer-Reviewed Original ResearchConceptsDirect oral anticoagulantsStandard of careRandomized controlled trialsOral anticoagulantsAtrial fibrillationCatheter-associated deep vein thrombosisCerebral venous sinus thrombosisControlled trialsVitamin K antagonistsThrombotic antiphospholipid syndromeEnd-stage renal diseaseLeft ventricular thrombusVenous thromboembolism treatmentVenous sinus thrombosisDeep vein thrombosisRheumatic heart diseaseReview of randomized controlled trialsEvidence-based reviewK antagonistsAntiphospholipid syndromeSinus thrombosisVentricular thrombusVein thrombosisThromboembolism treatmentVenous thrombosis
2023
PB0014 Do Antiphospholipid Antibodies Inform the Choice of Anticoagulant Agents in Patients with Atrial Fibrillation?
Bikdeli B, Bejjani A, Khairani C, Jimenez D, Monreal M, Siegal D, Kanthi Y, Barnes G, O’Donoghue M, Ruff C, Middeldorp S, Lopes R, Goldhaber S, Weitz J, Cushman M, Krumholz H, Lip G, Piazza G. PB0014 Do Antiphospholipid Antibodies Inform the Choice of Anticoagulant Agents in Patients with Atrial Fibrillation? Research And Practice In Thrombosis And Haemostasis 2023, 7: 100697. DOI: 10.1016/j.rpth.2023.100697.Peer-Reviewed Original ResearchReclassification of moderate aortic stenosis based on data-driven phenotyping of hemodynamic progression
Cho I, Kim W, Kim S, Ko K, Seong Y, Kim D, Seo J, Shim C, Ha J, Mori M, Gupta A, You S, Hong G, Krumholz H. Reclassification of moderate aortic stenosis based on data-driven phenotyping of hemodynamic progression. Scientific Reports 2023, 13: 6694. PMID: 37095171, PMCID: PMC10125992, DOI: 10.1038/s41598-023-33683-1.Peer-Reviewed Original ResearchConceptsRapid progression groupModerate aortic stenosisAortic valve replacementSlow progression groupAortic stenosisProgression groupHemodynamic progressionRapid progressionMore rapid progressionLatent class trajectory modelingTransthoracic echocardiography studyBetween-group differencesData-driven phenotypingPressure gradient measurementAVR ratesModerate ASCause mortalityValve replacementEchocardiography studyAtrial fibrillationTTE studiesEchocardiographic dataRisk factorsPredictive valuePatients
2022
Percutaneous Left Atrial Appendage Occlusion in Comparison to Non‐Vitamin K Antagonist Oral Anticoagulant Among Patients With Atrial Fibrillation
Noseworthy PA, Van Houten HK, Krumholz HM, Kent DM, Abraham NS, Graff‐Radford J, Alkhouli M, Henk HJ, Shah ND, Gersh BJ, Friedman PA, Holmes DR, Yao X. Percutaneous Left Atrial Appendage Occlusion in Comparison to Non‐Vitamin K Antagonist Oral Anticoagulant Among Patients With Atrial Fibrillation. Journal Of The American Heart Association 2022, 11: e027001. PMID: 36172961, PMCID: PMC9673739, DOI: 10.1161/jaha.121.027001.Peer-Reviewed Original ResearchConceptsComposite end pointAtrial appendage occlusionOral anticoagulantsAtrial fibrillationLower riskMajor bleedingSystemic embolismIntracranial bleedingAppendage occlusionNon-Vitamin K Antagonist Oral AnticoagulantsIschemic stroke/systemic embolismK Antagonist Oral AnticoagulantsPrimary composite end pointPropensity score overlap weightingStroke/systemic embolismEnd pointHigh bleeding riskSignificant differencesAntithrombotic regimensBleeding riskCause mortalityBaseline characteristicsComposite outcomeIschemic strokeSecondary outcomesInstitutional Variation in 30‐Day Complications Following Catheter Ablation of Atrial Fibrillation
Ngo L, Ali A, Ganesan A, Woodman R, Krumholz HM, Adams R, Ranasinghe I. Institutional Variation in 30‐Day Complications Following Catheter Ablation of Atrial Fibrillation. Journal Of The American Heart Association 2022, 11: e022009. PMID: 35156395, PMCID: PMC9245833, DOI: 10.1161/jaha.121.022009.Peer-Reviewed Original ResearchConceptsProcedure-related complicationsComplication rateAF ablationAtrial fibrillationCatheter ablationStroke/transient ischemic attackCare qualityTransient ischemic attackRisk of complicationsIschemic attackHospital stayCohort studyCommon complicationHospital dischargePericardial effusionCardiorespiratory failurePrimary outcomeProcedural characteristicsComplicationsPatientsHospitalStudy periodBackground ComplicationsPotential disparitiesFibrillation
2021
Predictors of increased mortality in untreated moderate aortic stenosis
Gupta A, Liu T, Pounds C, Sharma R, Yong C, Krumholz H, Leon M. Predictors of increased mortality in untreated moderate aortic stenosis. European Heart Journal 2021, 42: ehab724.1573. DOI: 10.1093/eurheartj/ehab724.1573.Peer-Reviewed Original ResearchModerate aortic stenosisLong-term mortalityCoronary artery diseaseSeverity of ASAortic stenosisArtery diseaseAtrial fibrillationHeart failureUntreated severe aortic stenosisWorse long-term mortalityPoor long-term survivalSevere aortic stenosisAortic valve replacementHigh-risk featuresMild aortic stenosisPrognosis of patientsKaplan-Meier analysisLong-term survivalElectronic health recordsValve replacementAS severityMale sexRisk factorsSeverity groupsHigh risk
2020
Clinical Outcomes With Beta-Blocker Use in Patients With Recent History of Myocardial Infarction
Jackevicius CA, Krumholz HM, Ross JS, Koh M, Chong A, Austin PC, Stukel TA, Azizi P, Ko DT. Clinical Outcomes With Beta-Blocker Use in Patients With Recent History of Myocardial Infarction. Canadian Journal Of Cardiology 2020, 36: 1633-1640. PMID: 32416066, DOI: 10.1016/j.cjca.2020.01.024.Peer-Reviewed Original ResearchConceptsPrior myocardial infarctionMyocardial infarctionStable patientsPopulation-based observational studyAngina 1 yearDeath/hospitalizationHistory of revascularisationBeta-blocker useMajor cardiovascular eventsHospital discharge diagnosisUse of BBsIndividual end pointsContemporary clinical trialsYears of ageCardiovascular eventsIndex dateCohort studyComposite outcomeBB useHeart failureMedian agePrimary outcomeClinical outcomesAtrial fibrillationDischarge diagnosis
2016
Incidence and Determinants of Traumatic Intracranial Bleeding Among Older Veterans Receiving Warfarin for Atrial Fibrillation
Dodson JA, Petrone A, Gagnon DR, Tinetti ME, Krumholz HM, Gaziano JM. Incidence and Determinants of Traumatic Intracranial Bleeding Among Older Veterans Receiving Warfarin for Atrial Fibrillation. JAMA Cardiology 2016, 1: 65. PMID: 27437657, PMCID: PMC5600874, DOI: 10.1001/jamacardio.2015.0345.Peer-Reviewed Original ResearchConceptsTraumatic intracranial bleedingIntracranial bleedingInternational normalized ratioIschemic strokeAtrial fibrillationIncidence rateAnticonvulsant useWarfarin therapyNormalized ratioRisk factorsOlder adultsVeterans AffairsCox proportional hazards regressionVA electronic medical recordsMean patient agePatients 75 yearsRetrospective cohort studyClinical Modification codesCoronary artery diseaseProportional hazards regressionService claims dataVA administrative dataSignificant predictorsHealth care professionalsElectronic medical records
2011
Gender Differences in Presentation, Management, and In-Hospital Outcomes for Patients with AMI in a Lower-Middle Income Country: Evidence from Egypt
Butala NM, Desai MM, Linnander EL, Wong YR, Mikhail DG, Ott LS, Spertus JA, Bradley EH, Aaty AA, Abdelfattah A, Gamal A, Kholeif H, Baz M, Allam AH, Krumholz HM. Gender Differences in Presentation, Management, and In-Hospital Outcomes for Patients with AMI in a Lower-Middle Income Country: Evidence from Egypt. PLOS ONE 2011, 6: e25904. PMID: 22022463, PMCID: PMC3192760, DOI: 10.1371/journal.pone.0025904.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHospital outcomesFemale patientsInitial presentationClinical managementDiagnosis of AMIIncome countriesIn-Hospital OutcomesOutcomes of patientsTime of presentationMultivariate logistic regressionGender differencesQuality of careLow-middle income countriesHospital mortalityHospital deathDiabetes mellitusHeart failureAtrial fibrillationHigher BMIMyocardial infarctionCardiovascular diseaseRegistry dataHigh-income countriesEgyptian hospitals
2006
Recursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery
Sedrakyan A, Zhang H, Treasure T, Krumholz HM. Recursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery. American Heart Journal 2006, 151: 720-724. PMID: 16504639, DOI: 10.1016/j.ahj.2005.05.010.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryAtrial fibrillationLow-risk groupAggressive prophylaxisRelative riskPredictors of AFArtery bypass graft surgeryCoronary artery bypass surgeryRisk of AFYale-New Haven HospitalOnly ejection fractionPreoperative atrial fibrillationBypass graft surgeryArtery bypass surgeryCoronary artery diseasePreoperative risk stratificationHigh-risk groupHeart disease severityPossible adverse eventsOlder age subgroupsArrhythmia prophylaxisGraft surgeryProphylactic therapyAdverse eventsBypass surgery
2005
The generalizability of observational data to elderly patients was dependent on the research question in a systematic review
Gross CP, Garg PP, Krumholz HM. The generalizability of observational data to elderly patients was dependent on the research question in a systematic review. Journal Of Clinical Epidemiology 2005, 58: 130-137. PMID: 15680745, DOI: 10.1016/j.jclinepi.2004.10.001.Peer-Reviewed Original ResearchConceptsCooperative Cardiovascular ProjectIntracranial hemorrhageSystematic reviewBeta-blocker useElderly patientsAngiography useCommunity patientsAtrial fibrillationRisk factorsObservational studyOutcome measuresRCT dataPresentation delayGlobal UtilizationT-PAPatientsSimilar predictorsTreatment variationStudy questionsCCP dataGUSTOHemorrhageReviewFibrillationAbsolute rate
2003
Gender, age, and heart failure with preserved left ventricular systolic function
Masoudi FA, Havranek EP, Smith G, Fish RH, Steiner JF, Ordin DL, Krumholz HM. Gender, age, and heart failure with preserved left ventricular systolic function. Journal Of The American College Of Cardiology 2003, 41: 217-223. PMID: 12535812, DOI: 10.1016/s0735-1097(02)02696-7.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic functionImpaired left ventricular systolic functionVentricular systolic functionHeart failureSystolic functionFemale genderDiagnosis of HFMedical chart abstractionCoronary artery diseasePrincipal discharge diagnosisAge 65 yearsMultivariable logistic regressionCross-sectional studyPotential confounding variablesRenal insufficiencyChart abstractionClinical characteristicsElderly patientsArtery diseaseEjection fractionPulmonary diseasePatient factorsAtrial fibrillationDischarge diagnosisPotential confounders
2002
Risk and Predictors of Stroke After Myocardial Infarction Among the Elderly
Lichtman JH, Krumholz HM, Wang Y, Radford MJ, Brass LM. Risk and Predictors of Stroke After Myocardial Infarction Among the Elderly. Circulation 2002, 105: 1082-1087. PMID: 11877359, DOI: 10.1161/hc0902.104708.Peer-Reviewed Original ResearchConceptsMonths of dischargeRisk of strokeAcute myocardial infarctionMyocardial infarctionIschemic strokeOlder patientsStroke admission ratesPatients 75 yearsPeripheral vascular diseasePredictors of strokeRisk stratification scoresRate of admissionSimple clinical factorsPrior strokeStroke admissionsClinical factorsHospital admissionIndependent predictorsStratification scoresAtrial fibrillationBlack racePrincipal diagnosisVascular diseaseAdmission ratesMedicare patients
1999
Variations in and correlates of length of stay in academic hospitals among patients with heart failure resulting from systolic dysfunction.
Krumholz HM, Chen YT, Bradford WD, Cerese J. Variations in and correlates of length of stay in academic hospitals among patients with heart failure resulting from systolic dysfunction. The American Journal Of Managed Care 1999, 5: 715-23. PMID: 10538451.Peer-Reviewed Original ResearchConceptsLength of stayCongestive heart failureHeart failureSystolic dysfunctionPatient characteristicsAcademic hospitalCollaborative quality improvement projectIndividual hospitalsAdmission clinical characteristicsRetrospective cohort studyPrincipal discharge diagnosisNumber of patientsQuality improvement projectUniversity HealthSystem ConsortiumCorrelates of lengthHospital stayPeripheral edemaClinical characteristicsCohort studyRenal failureClinical factorsMajor complicationsHospital eventsRegression modelsAtrial fibrillation
1998
Warfarin Use Following Ischemic Stroke Among Medicare Patients With Atrial Fibrillation
Brass LM, Krumholz HM, Scinto JD, Mathur D, Radford M. Warfarin Use Following Ischemic Stroke Among Medicare Patients With Atrial Fibrillation. JAMA Internal Medicine 1998, 158: 2093-2100. PMID: 9801175, DOI: 10.1001/archinte.158.19.2093.Peer-Reviewed Original ResearchConceptsUse of warfarinAtrial fibrillationIschemic strokeRecurrent strokeWarfarin useElderly patientsPrincipal diagnosisMedicare patientsLower riskConnecticut Peer Review OrganizationRegimen of warfarinElderly stroke patientsRisk of strokeAcute myocardial infarctionHigh-risk populationHigh rateChart reviewPeer review organizationsStroke patientsMyocardial infarctionWarfarin sodiumPatientsWarfarinFibrillationAnticoagulation
1997
Warfarin use among patients with atrial fibrillation.
Brass L, Krumholz H, Scinto J, Radford M. Warfarin use among patients with atrial fibrillation. Stroke 1997, 28: 2382-9. PMID: 9412618, DOI: 10.1161/01.str.28.12.2382.Peer-Reviewed Original ResearchConceptsAtrial fibrillationAdditional vascular risk factorsConnecticut Peer Review OrganizationRate of strokeVascular risk factorsStroke preventionWarfarin anticoagulationChart reviewElderly patientsRelative contraindicationPeer review organizationsRisk factorsMedicare patientsAnticoagulationHigh riskPatientsWarfarinFibrillationStrokeContraindicationsAspirinReview organizationsPopulation sampleHospitalizationMonthsA collaborative project in Connecticut to improve the care of patients with acute myocardial infarction.
Meehan TP, Radford MJ, Vaccarino LV, Gottlieb LD, McGovern-Hughes B, Herman MV, Revkin JH, Therrien ML, Petrillo MK, Krumholz HM. A collaborative project in Connecticut to improve the care of patients with acute myocardial infarction. Connecticut Medicine 1997, 61: 147-55. PMID: 9097486.Peer-Reviewed Original ResearchConceptsConnecticut Peer Review OrganizationPeer review organizationsCare of patientsAcute myocardial infarction careChart abstraction toolUse of thrombolyticsAcute myocardial infarctionMyocardial infarction careStaff education sessionsNon-Medicare patientsBeta blockersAtrial fibrillationAppropriate medicationEmergency departmentMyocardial infarctionQI interventionsLocal hospitalImprovement interventionsEducation sessionsHospitalQI planPatientsIndividual hospitalsQI activitiesQI project
1996
A Collaborative Project in Connecticut to Improve the Care of Patients with Acute Myocardial Infarction
Meehan T, Radford M, Vaccarino L, Gottlieb L, McGovern-Hughes B, Herman M, Revkin J, Therrien M, Petrillo M, Krumholz H. A Collaborative Project in Connecticut to Improve the Care of Patients with Acute Myocardial Infarction. The Joint Commission Journal On Quality And Patient Safety 1996, 22: 751-761. PMID: 8937949, DOI: 10.1016/s1070-3241(16)30280-2.Peer-Reviewed Original ResearchConceptsConnecticut Peer Review OrganizationPeer review organizationsCare of patientsAcute myocardial infarction careChart abstraction toolUse of thrombolyticsAcute myocardial infarctionMyocardial infarction careStaff education sessionsNon-Medicare patientsBeta blockersAtrial fibrillationAppropriate medicationEmergency departmentMyocardial infarctionQI interventionsLocal hospitalImprovement interventionsEducation sessionsHospitalQI planPatientsIndividual hospitalsQI activitiesQI project
1993
Cardioversion from Atrial Fibrillation without Prolonged Anticoagulation with Use of Transesophageal Echocardiography to Exclude the Presence of Atrial Thrombi
Manning W, Silverman D, Gordon S, Krumholz H, Douglas P. Cardioversion from Atrial Fibrillation without Prolonged Anticoagulation with Use of Transesophageal Echocardiography to Exclude the Presence of Atrial Thrombi. New England Journal Of Medicine 1993, 328: 750-755. PMID: 8437595, DOI: 10.1056/nejm199303183281102.Peer-Reviewed Original ResearchConceptsAtrial thrombusLong-term anticoagulationAtrial fibrillationTransesophageal echocardiographyOral anticoagulationEarly cardioversionTransthoracic echocardiographyLong-term oral anticoagulationConventional noninvasive techniquesOral anticoagulation therapyShort-term anticoagulationPresence of thrombusAnticoagulation therapyEmbolic eventsQualifying patientsConsecutive patientsProlonged anticoagulationSuccessful cardioversionSinus rhythmAnticoagulationCardioversionEchocardiographyPatientsThrombusFibrillation