2014
Trends in Early Aspirin Use Among Patients With Acute Myocardial Infarction in China, 2001–2011: The China PEACE‐Retrospective AMI Study
Gao Y, Masoudi FA, Hu S, Li J, Zhang H, Li X, Desai NR, Krumholz HM, Jiang L, Group T. Trends in Early Aspirin Use Among Patients With Acute Myocardial Infarction in China, 2001–2011: The China PEACE‐Retrospective AMI Study. Journal Of The American Heart Association 2014, 3: e001250. PMID: 25304853, PMCID: PMC4323779, DOI: 10.1161/jaha.114.001250.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAspirinChinaCohort StudiesConfidence IntervalsDose-Response Relationship, DrugDrug Administration ScheduleFemaleHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioRetrospective StudiesRisk AssessmentRural PopulationSecondary PreventionSex FactorsSurvival AnalysisSurvival RateUrban PopulationConceptsAcute myocardial infarctionMyocardial infarctionAspirin useEarly treatmentSegment elevation acute myocardial infarctionElevation acute myocardial infarctionEarly useChina PEACE-Retrospective AMI StudyEarly aspirin therapyEarly aspirin useLimited healthcare resourcesAspirin therapyCardiogenic shockChest discomfortReperfusion therapyRate of useChina PatientRetrospective studyPatient groupFinal diagnosisHealthcare resourcesInfarctionPatientsAspirinAMI study
2006
Trends in Acute Myocardial Infarction in 4 US States Between 1992 and 2001
Masoudi FA, Foody JM, Havranek EP, Wang Y, Radford MJ, Allman RM, Gold J, Wiblin RT, Krumholz HM. Trends in Acute Myocardial Infarction in 4 US States Between 1992 and 2001. Circulation 2006, 114: 2806-2814. PMID: 17145994, DOI: 10.1161/circulationaha.106.611707.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAngiotensin-converting enzyme inhibitorEnzyme inhibitorsPrimary discharge diagnosisHealth system perspectiveQuality of careMore comorbiditiesClinical characteristicsDischarge diagnosisMyocardial infarctionAMI careMedicare patientsMultivariable modelTreatment criteriaMedicare populationTreatment ratesAspirinHealth impactsMortalityCarePresent studyOutcomesIndicator definitionsDiverse populationsInhibitorsImpact of Medication Therapy Discontinuation on Mortality After Myocardial Infarction
Ho PM, Spertus JA, Masoudi FA, Reid KJ, Peterson ED, Magid DJ, Krumholz HM, Rumsfeld JS. Impact of Medication Therapy Discontinuation on Mortality After Myocardial Infarction. JAMA Internal Medicine 2006, 166: 1842-1847. PMID: 17000940, DOI: 10.1001/archinte.166.17.1842.Peer-Reviewed Original ResearchConceptsTherapy discontinuationMyocardial infarctionEvidence-based medicationsMulticenter prospective cohortUse of aspirinMultivariable survival analysisTransitions of careDiscontinuation of useProspective registryMortality benefitProspective cohortMultivariable analysisOutpatient settingMI hospitalizationDiscontinuationMortality riskMedicationsPatientsSurvival analysisHigh mortalityMortalityTreatment factorsMonthsInfarctionAspirinPhysician Board Certification and the Care and Outcomes of Elderly Patients with Acute Myocardial Infarction
Chen J, Rathore SS, Wang Y, Radford MJ, Krumholz HM. Physician Board Certification and the Care and Outcomes of Elderly Patients with Acute Myocardial Infarction. Journal Of General Internal Medicine 2006, 21: 238-244. PMID: 16637823, PMCID: PMC1828098, DOI: 10.1111/j.1525-1497.2006.00326.x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionBoard-certified physiciansPhysician board certificationMyocardial infarctionFamily practitionersInternal medicineBoard certificationHigher useUse of aspirinQuality of careMultivariate regression analysisBoard-certified internistsElderly patientsHospitalized patientsClinical guidelinesMedicare patientsAspirinPatientsMortalityPhysiciansFamily practiceCareInfarctionRegression analysisCardiologists
2005
Aspirin Use in Older Patients With Heart Failure and Coronary Artery Disease National Prescription Patterns and Relationship With Outcomes
Masoudi FA, Wolfe P, Havranek EP, Rathore SS, Foody JM, Krumholz HM. Aspirin Use in Older Patients With Heart Failure and Coronary Artery Disease National Prescription Patterns and Relationship With Outcomes. Journal Of The American College Of Cardiology 2005, 46: 955-962. PMID: 16168275, DOI: 10.1016/j.jacc.2004.07.062.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseHeart failureAspirin prescriptionAspirin useRenal insufficiencyLower riskLower unadjusted ratesNational prescription patternsUse of aspirinClustering of patientsEvidence of harmCause readmissionCoronary eventsOlder patientsPrescription patternsSecondary preventionArtery diseaseACE inhibitorsMultivariable analysisUnadjusted ratesHospital characteristicsTreatment benefitMedicare beneficiariesAspirinPatientsSex and Racial Differences in the Management of Acute Myocardial Infarction, 1994 through 2002
Vaccarino V, Rathore SS, Wenger NK, Frederick PD, Abramson JL, Barron HV, Manhapra A, Mallik S, Krumholz HM. Sex and Racial Differences in the Management of Acute Myocardial Infarction, 1994 through 2002. New England Journal Of Medicine 2005, 353: 671-682. PMID: 16107620, PMCID: PMC2805130, DOI: 10.1056/nejmsa032214.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAspirinBlack PeopleCoronary AngiographyFemaleHealth Services AccessibilityHospital MortalityHumansLogistic ModelsMaleMiddle AgedMyocardial InfarctionMyocardial RevascularizationPlatelet Aggregation InhibitorsProcess Assessment, Health CareQuality of Health CareRisk FactorsSex FactorsUnited StatesWhite PeopleConceptsUse of aspirinMyocardial infarctionReperfusion therapyCoronary angiographyRacial differencesTreatment of patientsHospital deathHospital mortalityMultivariable adjustmentUnadjusted analysesNational registryInfarctionWhite womenAspirinAngiographyTherapyWhite menSexPatientsBlack womenSex differencesParticular treatmentBlack menWomenDeath
2004
The case for an adverse interaction between aspirin and non-steroidal anti-inflammatory drugs Is it time to believe the hype?**editorials published in the journal of the american college of cardiology reflect the views of the authors and do not necessarily represent the views of jacc or the american college of cardiology.
Curtis JP, Krumholz HM. The case for an adverse interaction between aspirin and non-steroidal anti-inflammatory drugs Is it time to believe the hype?**editorials published in the journal of the american college of cardiology reflect the views of the authors and do not necessarily represent the views of jacc or the american college of cardiology. Journal Of The American College Of Cardiology 2004, 43: 991-993. PMID: 15028355, DOI: 10.1016/j.jacc.2004.01.001.Commentaries, Editorials and Letters
2003
Regional variation in the treatment and outcomes of myocardial infarction: investigating New England’s advantage
Krumholz HM, Chen J, Rathore SS, Wang Y, Radford MJ. Regional variation in the treatment and outcomes of myocardial infarction: investigating New England’s advantage. American Heart Journal 2003, 146: 242-249. PMID: 12891191, DOI: 10.1016/s0002-8703(03)00237-0.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAngioplasty, Balloon, CoronaryAspirinCoronary Artery BypassFemaleFibrinolytic AgentsHospitalizationHumansLogistic ModelsMaleMyocardial InfarctionNew EnglandOutcome Assessment, Health CarePractice Patterns, Physicians'Quality of Health CareThrombolytic TherapyUnited StatesConceptsPractice patternsMortality rateReperfusion therapyBetter short-term outcomesMedical therapy useShort-term outcomesQuality of careHierarchical logistic regression modelsMyocardial infarction treatmentLogistic regression modelsTherapy useMyocardial infarctionHospital characteristicsPhysician characteristicsProvider characteristicsBetter outcomesInfarction treatmentPatientsMI treatmentRegional variationLow useRegional differencesAspirinHospitalTherapy
2002
Nonsteroidal antiinflammatory drugs after acute myocardial infarction
Ko D, Wang Y, Berger AK, Radford MJ, Krumholz HM. Nonsteroidal antiinflammatory drugs after acute myocardial infarction. American Heart Journal 2002, 143: 475-481. PMID: 11868054, DOI: 10.1067/mhj.2002.121270.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNonsteroidal antiinflammatory drugsNSAID therapyMyocardial infarctionAddition of aspirinMortality rateAspirin therapyElderly patientsAntiinflammatory drugsMedicare beneficiariesUse of NSAIDsRetrospective medical record reviewAdditional survival benefitMedical record reviewCooperative Cardiovascular ProjectElderly Medicare beneficiariesHospital dischargeOlder patientsSurvival benefitRecord reviewClinical informationInfarctionAspirinPatientsMedications
2001
Quality of care among elderly patients hospitalized with unstable angina
Shahi C, Rathore S, Wang Y, Thakur R, Wu W, Lewis J, Petrillo M, Radford M, Krumholz H. Quality of care among elderly patients hospitalized with unstable angina. American Heart Journal 2001, 142: 263-270. PMID: 11479465, DOI: 10.1067/mhj.2001.116477.Peer-Reviewed Original ResearchConceptsQuality of careMinutes of admissionUnstable anginaHealth care policyElderly patientsTherapeutic anticoagulationIntravenous heparinElectrocardiographic examinationCare policyPrescription of aspirinUse of aspirinHalf of patientsEligible patientsRisk stratificationConnecticut hospitalsElderly MedicareAnginaPatientsTherapeutic contraindicationsTherapeutic interventionsAspirinAdmissionHospitalCareAnticoagulationAspirin and angiotensin-converting enzyme inhibitors among elderly survivors of hospitalization for an acute myocardial infarction
Krumholz H, Chen Y, Wang Y, Radford M. Aspirin and angiotensin-converting enzyme inhibitors among elderly survivors of hospitalization for an acute myocardial infarction. ACC Current Journal Review 2001, 10: 7. DOI: 10.1016/s1062-1458(01)00289-6.Peer-Reviewed Original ResearchAspirin and Angiotensin-Converting Enzyme Inhibitors Among Elderly Survivors of Hospitalization for an Acute Myocardial Infarction
Krumholz HM, Chen YT, Wang Y, Radford MJ. Aspirin and Angiotensin-Converting Enzyme Inhibitors Among Elderly Survivors of Hospitalization for an Acute Myocardial Infarction. JAMA Internal Medicine 2001, 161: 538-544. PMID: 11252112, DOI: 10.1001/archinte.161.4.538.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionACE inhibitorsMyocardial infarctionInteraction of aspirinEnzyme inhibitorsAngiotensin-converting enzyme inhibitorAngiotensin converting enzyme (ACE) inhibitorsElderly patientsSecondary preventionRandomized trialsElderly survivorsLower riskAspirinPatientsMultivariate analysisHospitalizationMortalityMedicationsInfarctionInhibitorsTherapySurvivorsTrialsPreventionAspirin and the Treatment of Heart Failure in the Elderly
Krumholz HM, Chen YT, Radford MJ. Aspirin and the Treatment of Heart Failure in the Elderly. JAMA Internal Medicine 2001, 161: 577-582. PMID: 11252118, DOI: 10.1001/archinte.161.4.577.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseHeart failureArtery diseaseBenefits of aspirinPatients 65 yearsRetrospective cohort studyUse of aspirinGroup of patientsAspirin prescriptionAspirin therapyCohort studyDischarge medicationsOlder patientsPatient characteristicsRandomized trialsVascular diseaseTreatment characteristicsConnecticut hospitalsBaseline differencesAspirinPatientsLower mortalityStrong associationDiseaseStudy sample
1999
Performance of the '100 top hospitals': what does the report card report?
Chen J, Radford MJ, Wang Y, Marciniak TA, Krumholz HM. Performance of the '100 top hospitals': what does the report card report? Health Affairs 1999, 18: 53-68. PMID: 10425843, DOI: 10.1377/hlthaff.18.4.53.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionElderly AMI patientsThirty-day mortalityUse of aspirinLower readmission ratesHospital peer groupsTop hospitalsReadmission ratesAMI patientsSuperior clinical performanceHospital studyMyocardial infarctionHospital costsMedicare patientsBetter outcomesHospitalBetter carePatientsClinical performanceLower lengthReperfusionInfarctionAspirinStayMortalityDo “America's Best Hospitals” Perform Better for Acute Myocardial Infarction?
Chen J, Radford M, Wang Y, Marciniak T, Krumholz H. Do “America's Best Hospitals” Perform Better for Acute Myocardial Infarction? New England Journal Of Medicine 1999, 340: 286-292. PMID: 9920954, DOI: 10.1056/nejm199901283400407.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAngioplasty, Balloon, CoronaryAspirinFemaleHealth Care SurveysHospitalsHumansLogistic ModelsMaleMedicareMultivariate AnalysisMyocardial InfarctionOutcome and Process Assessment, Health CareQuality of Health CareSeverity of Illness IndexThrombolytic TherapyUnited StatesConceptsAcute myocardial infarctionShort-term mortalityMyocardial infarctionAmerica's Best HospitalsBest HospitalsSurvival advantageLower short-term mortalityBeta-blocker therapyRates of therapyHigh rateOutcomes of patientsUse of aspirinCooperative Cardiovascular ProjectElderly Medicare beneficiariesType of hospitalQuality of hospitalsReperfusion therapyElderly patientsRate of useBypass surgeryCardiac catheterizationCoronary angioplastyMedicare beneficiariesInfarctionAspirin
1997
Warfarin use among patients with atrial fibrillation.
Brass L, Krumholz H, Scinto J, Radford M. Warfarin use among patients with atrial fibrillation. Stroke 1997, 28: 2382-9. PMID: 9412618, DOI: 10.1161/01.str.28.12.2382.Peer-Reviewed Original ResearchConceptsAtrial fibrillationAdditional vascular risk factorsConnecticut Peer Review OrganizationRate of strokeVascular risk factorsStroke preventionWarfarin anticoagulationChart reviewElderly patientsRelative contraindicationPeer review organizationsRisk factorsMedicare patientsAnticoagulationHigh riskPatientsWarfarinFibrillationStrokeContraindicationsAspirinReview organizationsPopulation sampleHospitalizationMonths