2023
Mapping Lesion-Related Epilepsy to a Human Brain Network
Schaper F, Nordberg J, Cohen A, Lin C, Hsu J, Horn A, Ferguson M, Siddiqi S, Drew W, Soussand L, Winkler A, Simó M, Bruna J, Rheims S, Guenot M, Bucci M, Nummenmaa L, Staals J, Colon A, Ackermans L, Bubrick E, Peters J, Wu O, Rost N, Grafman J, Blumenfeld H, Temel Y, Rouhl R, Joutsa J, Fox M. Mapping Lesion-Related Epilepsy to a Human Brain Network. JAMA Neurology 2023, 80: 891-902. PMID: 37399040, PMCID: PMC10318550, DOI: 10.1001/jamaneurol.2023.1988.Peer-Reviewed Original ResearchConceptsRisk of epilepsyLesion locationBrain regionsPoststroke epilepsyControl patientsSeizure controlBrain lesionsIndependent cohortBrain networksLesion typeBrain stimulation sitesLesion network mappingLesion-related epilepsyImproved seizure controlDrug-resistant epilepsyCase-control studyBrain stimulation therapyHuman brain networksSpecific brain regionsDifferent lesion typesSpecific brain networksBasal gangliaVascular territoriesStimulation therapyMAIN OUTCOME
2019
Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study
Cohen E, Antwi P, Banz BC, Vincent P, Saha R, Arencibia CA, Ryu JH, Atac E, Saleem N, Tomatsu S, Swift K, Hu C, Krestel H, Farooque P, Levy S, Wu J, Crowley M, Vaca FE, Blumenfeld H. Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study. Epilepsia 2019, 61: 19-28. PMID: 31646628, PMCID: PMC7424790, DOI: 10.1111/epi.16356.Peer-Reviewed Original ResearchConceptsEpileptiform dischargesGeneralized epileptiform dischargesEEG amplitudeClinical seizuresElectroencephalographic featuresGeneralized epilepsyLarger sample sizeDriving impairmentClinical accompanimentBaseline testingPilot studyMotor vehicle safetyLonger durationSimultaneous EEGSeizuresVisual stimuliEEGSubjectsStimuliRiskSafetyDurationSample sizeResponseEpilepsy
2017
A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception
Herman WX, Smith RE, Kronemer SI, Watsky RE, Chen WC, Gober LM, Touloumes GJ, Khosla M, Raja A, Horien CL, Morse EC, Botta KL, Hirsch LJ, Alkawadri R, Gerrard JL, Spencer DD, Blumenfeld H. A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception. Cerebral Cortex 2017, 29: 461-474. PMID: 29194517, PMCID: PMC6319177, DOI: 10.1093/cercor/bhx327.Peer-Reviewed Original ResearchConceptsCerebral cortexVisual cortexHuman cerebral cortexDirect electrical recordingHz gamma powerDefault mode networkConscious perceptionNeuronal activityAssociation cortexBrain disordersIntracranial electrodesCortexMonophasic wavesMode networkCortex networkGamma powerGamma activationVisual thresholdFirst secondElectrical recordingsStimulus processingInitial activationStimuliActivationFindings
2016
Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study
Guo JN, Kim R, Chen Y, Negishi M, Jhun S, Weiss S, Ryu JH, Bai X, Xiao W, Feeney E, Rodriguez-Fernandez J, Mistry H, Crunelli V, Crowley MJ, Mayes LC, Constable RT, Blumenfeld H. Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. The Lancet Neurology 2016, 15: 1336-1345. PMID: 27839650, PMCID: PMC5504428, DOI: 10.1016/s1474-4422(16)30295-2.Peer-Reviewed Original ResearchConceptsAbsence seizuresCross-sectional studyFMRI amplitudeFunctional MRIBehavioral impairmentsJuvenile absence epilepsyBilateral spike-wave dischargesOnset of seizuresPediatric neurology practiceNational InstituteSpike-wave dischargesPhysiological changesBehavioral responsesDefault mode networkImpaired task performanceSeizure durationImpaired consciousnessElectroencephalography changesNeurology practiceAbsence epilepsyFMRI changesBehavioral deficitsMAIN OUTCOMEBehavioral testingEEG changes
2010
Impaired consciousness in temporal lobe seizures: role of cortical slow activity
Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MC, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain 2010, 133: 3764-3777. PMID: 21081551, PMCID: PMC2995886, DOI: 10.1093/brain/awq316.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresSlow wave activityTemporal lobe epilepsySimple partial seizuresSubcortical arousal systemsImpaired consciousnessSeizure activityTemporal lobeLobe epilepsyArousal systemCortical functionFocal temporal lobe seizuresHz slow wave activityMesial temporal lobe epilepsyCortical slow activityDepressed cortical functionNetwork inhibition hypothesisTemporal lobe disordersComplex partial seizuresBilateral temporal lobesLanguage-dominant temporal lobeSlow wavesCortical-subcortical networksPowerful inhibitory effectIntracranial electroencephalography recordingsDynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging
Bai X, Vestal M, Berman R, Negishi M, Spann M, Vega C, Desalvo M, Novotny EJ, Constable RT, Blumenfeld H. Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging. Journal Of Neuroscience 2010, 30: 5884-5893. PMID: 20427649, PMCID: PMC2946206, DOI: 10.1523/jneurosci.5101-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingCerebrovascular CirculationChildElectroencephalographyEpilepsy, AbsenceFemaleHumansLinear ModelsMagnetic Resonance ImagingMaleModels, NeurologicalMotor ActivityNeuropsychological TestsPsychomotor PerformanceSeizuresSignal Processing, Computer-AssistedTime FactorsConceptsTypical childhood absence seizuresChildhood absence seizuresAbsence seizuresFMRI decreasesSeizure onsetHz spike-wave dischargesMagnetic resonance imaging changesFunctional magnetic resonance imaging (fMRI) changesTime courseHz generalized spikeSpike-wave dischargesFunctional magnetic resonance imagingMagnetic resonance imagingRepetitive tapping taskLateral parietal cortexLateral frontal cortexImpaired consciousnessPediatric patientsImaging changesEEG time-frequency analysisSeizure endMean durationSeizure initiationGeneralized spikeFMRI changes
2000
Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks
Blumenfeld H, McCormick D. Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks. Journal Of Neuroscience 2000, 20: 5153-5162. PMID: 10864972, PMCID: PMC6772273, DOI: 10.1523/jneurosci.20-13-05153.2000.Peer-Reviewed Original ResearchConceptsParoxysmal oscillationsThalamic burstsReceptor antagonist CGP 35348Corticothalamic tractsSpindle wavesAntagonist CGP 35348Receptor antagonist picrotoxinSlow-wave sleepHz oscillationsHigh-frequency burstsNormal action potentialPerigeniculate neuronsCGP 35348Antagonist picrotoxinSlow IPSPCorticothalamic inputsFast IPSPsThalamocortical neuronsCortical influencesAbsence seizuresBurst firingCortical neuronsCortical firingThalamocortical networkCorticothalamic networks