2015
Decreased Subcortical Cholinergic Arousal in Focal Seizures
Motelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H. Decreased Subcortical Cholinergic Arousal in Focal Seizures. Neuron 2015, 85: 561-572. PMID: 25654258, PMCID: PMC4319118, DOI: 10.1016/j.neuron.2014.12.058.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresFocal temporal lobe seizuresReduced cholinergic neurotransmissionBilateral temporal lobesLoss of consciousnessPedunculopontine tegmental nucleusQuality of lifeBrainstem arousal systemsFunctional magnetic resonanceSeizure spreadCholinergic neuronsImpaired consciousnessFocal seizuresBasal forebrainAnterior hypothalamusCholinergic neurotransmissionTegmental nucleusLateral septumCortical functionRodent modelsTemporal lobeSubcortical regionsSeizuresImpair consciousnessSubcortical arousal
2013
Temporal Lobe Seizures
Furman M, Blumenfeld H. Temporal Lobe Seizures. 2013, 51-62. DOI: 10.1007/978-3-642-37580-4_4.Peer-Reviewed Original ResearchTemporal lobe seizuresTemporal epilepsyTemporal lobeFocal temporal lobe seizuresNetwork inhibition hypothesisSlow electroencephalogram activityLoss of consciousnessParietal association cortexImpaired consciousnessCortical dysfunctionSide effectsAnimal modelsNovel treatmentsAssociation cortexDeep anesthesiaAwake stateHuman patientsElectrophysiological techniquesMemory lossSeizuresElectroencephalogram (EEG) activityElectrophysiological dataEpilepsyCortexLobe
2010
Impaired consciousness in temporal lobe seizures: role of cortical slow activity
Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MC, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain 2010, 133: 3764-3777. PMID: 21081551, PMCID: PMC2995886, DOI: 10.1093/brain/awq316.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresSlow wave activityTemporal lobe epilepsySimple partial seizuresSubcortical arousal systemsImpaired consciousnessSeizure activityTemporal lobeLobe epilepsyArousal systemCortical functionFocal temporal lobe seizuresHz slow wave activityMesial temporal lobe epilepsyCortical slow activityDepressed cortical functionNetwork inhibition hypothesisTemporal lobe disordersComplex partial seizuresBilateral temporal lobesLanguage-dominant temporal lobeSlow wavesCortical-subcortical networksPowerful inhibitory effectIntracranial electroencephalography recordings