2022
Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity
Kronemer S, Aksen M, Ding J, Ryu J, Xin Q, Ding Z, Prince J, Kwon H, Khalaf A, Forman S, Jin D, Wang K, Chen K, Hu C, Agarwal A, Saberski E, Wafa S, Morgan O, Wu J, Christison-Lagay K, Hasulak N, Morrell M, Urban A, Todd Constable R, Pitts M, Mark Richardson R, Crowley M, Blumenfeld H. Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity. Nature Communications 2022, 13: 7342. PMID: 36446792, PMCID: PMC9707162, DOI: 10.1038/s41467-022-35117-4.Peer-Reviewed Original ResearchConceptsSubcortical networksConscious visual perceptionVisual perception taskNeurophysiology of consciousnessExecutive control networkMajor brain networksDefault mode networkFrontal eye fieldOvert reportPerception taskVisual consciousnessConscious perceptionFusiform cortexVisual perceptionAnterior insulaConscious experienceSalience networkBrain networksMode networkAnterior cingulateEye fieldTask reportControl networkFMRI changesNeural circuits
2016
Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study
Guo JN, Kim R, Chen Y, Negishi M, Jhun S, Weiss S, Ryu JH, Bai X, Xiao W, Feeney E, Rodriguez-Fernandez J, Mistry H, Crunelli V, Crowley MJ, Mayes LC, Constable RT, Blumenfeld H. Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. The Lancet Neurology 2016, 15: 1336-1345. PMID: 27839650, PMCID: PMC5504428, DOI: 10.1016/s1474-4422(16)30295-2.Peer-Reviewed Original ResearchConceptsAbsence seizuresCross-sectional studyFMRI amplitudeFunctional MRIBehavioral impairmentsJuvenile absence epilepsyBilateral spike-wave dischargesOnset of seizuresPediatric neurology practiceNational InstituteSpike-wave dischargesPhysiological changesBehavioral responsesDefault mode networkImpaired task performanceSeizure durationImpaired consciousnessElectroencephalography changesNeurology practiceAbsence epilepsyFMRI changesBehavioral deficitsMAIN OUTCOMEBehavioral testingEEG changes
2014
Physiological Basis of BOLD fMRI Decreases
Kim R, Hyder F, Blumenfeld H. Physiological Basis of BOLD fMRI Decreases. Neuromethods 2014, 88: 221-236. DOI: 10.1007/978-1-4939-0724-3_11.Peer-Reviewed Original ResearchCerebral blood flowCerebral blood volumeFMRI decreasesNeuronal activityLocal field potentialsNeuronal firingMagnetic resonance imaging (MRI) signal changesFunctional magnetic resonance imaging (fMRI) signal changesSpike-wave seizuresCortical slow oscillationsFMRI signal changesBOLD fMRI signalHippocampal seizuresSignal changesBasal gangliaDirect electrophysiological measurementsFMRI changesPhysiological basisSomatosensory stimulationBlood flowParadoxical decreaseAnimal modelsBlood volumeAnimal studiesCombined neuroimaging
2010
Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging
Bai X, Vestal M, Berman R, Negishi M, Spann M, Vega C, Desalvo M, Novotny EJ, Constable RT, Blumenfeld H. Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging. Journal Of Neuroscience 2010, 30: 5884-5893. PMID: 20427649, PMCID: PMC2946206, DOI: 10.1523/jneurosci.5101-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingCerebrovascular CirculationChildElectroencephalographyEpilepsy, AbsenceFemaleHumansLinear ModelsMagnetic Resonance ImagingMaleModels, NeurologicalMotor ActivityNeuropsychological TestsPsychomotor PerformanceSeizuresSignal Processing, Computer-AssistedTime FactorsConceptsTypical childhood absence seizuresChildhood absence seizuresAbsence seizuresFMRI decreasesSeizure onsetHz spike-wave dischargesMagnetic resonance imaging changesFunctional magnetic resonance imaging (fMRI) changesTime courseHz generalized spikeSpike-wave dischargesFunctional magnetic resonance imagingMagnetic resonance imagingRepetitive tapping taskLateral parietal cortexLateral frontal cortexImpaired consciousnessPediatric patientsImaging changesEEG time-frequency analysisSeizure endMean durationSeizure initiationGeneralized spikeFMRI changes