Featured Publications
Generalizing the per-protocol treatment effect: The case of ACTG A5095
Lu H, Cole S, Hall H, Schisterman E, Breger T, Edwards J, Westreich D. Generalizing the per-protocol treatment effect: The case of ACTG A5095. Clinical Trials 2018, 16: 52-62. PMID: 30326736, PMCID: PMC6693502, DOI: 10.1177/1740774518806311.Peer-Reviewed Original ResearchConceptsFour-drug antiretroviral regimenThree-drug regimenConventional intentionAntiretroviral regimenVirologic failureTreat comparisonProtocol deviationsRisk differenceTarget populationTreatment assignmentThree-drug armInverse probability weightsACTG A5095Protocol effectUS HIVHazard ratioRandomized trialsInverse oddsTreatment protocolRegimenUS individualsHIVProtocol estimatesTrialsProtocol analysis
2020
Sleep, sedentary activity, physical activity, and cognitive function among older adults: The National Health and Nutrition Examination Survey, 2011–2014
Wei J, Hou R, Xie L, Chandrasekar E, Lu H, Wang T, Li C, Xu H. Sleep, sedentary activity, physical activity, and cognitive function among older adults: The National Health and Nutrition Examination Survey, 2011–2014. Journal Of Science And Medicine In Sport 2020, 24: 189-194. PMID: 33032913, DOI: 10.1016/j.jsams.2020.09.013.Peer-Reviewed Original ResearchConceptsCognitive functionOlder adultsBetter cognitionSleep durationLong-term cognitive outcomesDigit Symbol Substitution TestAnimal Fluency TestAssociation of sleepFavorable cognitionsFluency testCognitive outcomesSelf-reported timeSubstitution TestSedentary activitiesPhysical activityCognitionLongitudinal studyExcessive sleepFuture researchNational HealthSleepGlobal Physical Activity QuestionnaireActivity statusPhysical Activity QuestionnaireNutrition Examination Survey
2019
Factors influencing caspofungin plasma concentrations in kidney transplant patients with high incidence of invasive fungal infections
Yang Q, Zhang T, Zhao D, Zhang Y, Dong Y, Sun D, Du Q, Zheng J, Lu H, Dong Y. Factors influencing caspofungin plasma concentrations in kidney transplant patients with high incidence of invasive fungal infections. Journal Of Clinical Pharmacy And Therapeutics 2019, 45: 72-80. PMID: 31468555, DOI: 10.1111/jcpt.13026.Peer-Reviewed Original ResearchConceptsKidney transplant patientsInvasive fungal infectionsTransplant patientsConcomitant medicationsPlasma concentrationsContinuous renal replacement therapyFungal infectionsRenal replacement therapyUncontrolled observational studiesAntifungal prophylaxisKidney recipientsTrough concentrationsBaseline diseaseReplacement therapyObservational studyHealthy volunteersCyclosporine AProphylaxisHigh incidencePatientsMultivariate analysisMedicationsALB concentrationLiquid chromatography-tandem mass spectrometry methodCandida sppLate-life depression and cognitive function among older adults in the U.S.: The National Health and Nutrition Examination Survey, 2011–2014
Wei J, Ying M, Xie L, Chandrasekar E, Lu H, Wang T, Li C. Late-life depression and cognitive function among older adults in the U.S.: The National Health and Nutrition Examination Survey, 2011–2014. Journal Of Psychiatric Research 2019, 111: 30-35. PMID: 30660811, DOI: 10.1016/j.jpsychires.2019.01.012.Peer-Reviewed Original ResearchConceptsCognitive functionOlder adultsLate-life depressionExecutive function/processing speedLower cognitionDepressive symptomsDomain-specific cognitive functionDigit Symbol Substitution TestAnimal Fluency TestWord recall testDelayed Word Recall TestLower cognitive functionRecall testOverall cognitionFluency testProcessing speedCognitionCognitive depressive symptomsSubstitution TestNational HealthZ-scoreSpecific domainsDepressionMultivariable linear regression modelsPatient Health Questionnaire
2018
Development and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database
Zhao Y, Lu H, Thai S, Li X, Hui J, Tang H, Zhai S, Sun L, Wang T. Development and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database. International Journal Of Clinical Pharmacy 2018, 40: 862-869. PMID: 29464448, DOI: 10.1007/s11096-018-0594-z.Peer-Reviewed Original ResearchConceptsDrug-induced anaphylaxisBeijing Pharmacovigilance DatabasePositive predictive valueAdverse drug eventsPharmacovigilance databaseAnaphylactic shockSpecific diagnosisSerious adverse drug eventsPhysician adjudicatorsChart abstractionAnaphylactic reactionsClinical criteriaDrug eventsAnaphylactoid reactionsMAIN OUTCOMEPredictive valueAnaphylaxisDiagnosisGold standardConfidence intervalsPatientsCriteria componentsHospitalDatabaseGreater number
2017
Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults
Gross A, Lu H, Meoni L, Gallo J, Schrack J, Sharrett A. Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults. Journal Of Alzheimer's Disease 2017, 59: 1349-1358. PMID: 28759969, DOI: 10.3233/jad-170290.Peer-Reviewed Original ResearchConceptsPhysical activityCox proportional hazards modelLate-life cognitionMidlife physical activityPhysical activity measuresProportional hazards modelOnset of dementiaCognitive testsNormal older adultsCross-sectional findingsRandomized trialsRegular exerciseMetabolic equivalentsDementia onsetObservational studyHazards modelDementiaActivity measuresCognitive healthOlder adultsBetter cognitionCross-sectional dataLater lifeCohortNull findings