Featured Publications
Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada. Clinical Infectious Diseases 2020, 73: e1408-e1414. PMID: 32780095, PMCID: PMC8492356, DOI: 10.1093/cid/ciaa1037.Peer-Reviewed Original ResearchMeSH KeywordsAdultCanadaCohort StudiesHIVHIV InfectionsHIV Integrase InhibitorsHumansTreatment OutcomeUnited StatesConceptsIntegrase strand transfer inhibitorsHuman immunodeficiency virusHazard ratioEFV groupAntiretroviral therapyStrand transfer inhibitorsClinical outcomesRisk differenceINSTI groupComposite outcomeImmunodeficiency virusClinical effectivenessNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapyEnd-stage liver diseaseLong-term clinical effectivenessEnd-stage renal diseaseLong-term clinical outcomesComposite clinical outcomeFirst ART regimenInitial ART regimensAdverse clinical outcomesModern antiretroviral therapyTransfer inhibitorsAcute myocardial infarctionInflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study
Lu H, Surkan P, Irwin M, Treisman G, Breen E, Sacktor N, Stall R, Wolinsky S, Jacobson L, Abraham A. Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study. American Journal Of Epidemiology 2019, 188: 1994-2003. PMID: 31642472, PMCID: PMC6825834, DOI: 10.1093/aje/kwz190.Peer-Reviewed Original ResearchMeSH KeywordsDepressionHIV InfectionsHumansInflammationMalePrevalenceProspective StudiesSexual and Gender MinoritiesUnited StatesConceptsHuman immunodeficiency virusMulticenter AIDS Cohort StudyAIDS Cohort StudyInflammatory processCohort studyHigher oddsDepressive symptomsSoluble tumor necrosis factor receptor 2Soluble interleukin-2 receptor αTumor necrosis factor receptor 2B-cell activating factorEpidemiological Studies Depression ScaleInterleukin-2 receptor αNecrosis factor receptor 2Relevant depression symptomsSoluble interleukin-6 receptorPathogenesis of depressionHigh-risk populationRisk of depressionFactor receptor 2Interleukin-6 receptorExploratory factor analysisHIV- menHIV- participantsInflammatory profileGeneralizing the per-protocol treatment effect: The case of ACTG A5095
Lu H, Cole S, Hall H, Schisterman E, Breger T, Edwards J, Westreich D. Generalizing the per-protocol treatment effect: The case of ACTG A5095. Clinical Trials 2018, 16: 52-62. PMID: 30326736, PMCID: PMC6693502, DOI: 10.1177/1740774518806311.Peer-Reviewed Original ResearchConceptsFour-drug antiretroviral regimenThree-drug regimenConventional intentionAntiretroviral regimenVirologic failureTreat comparisonProtocol deviationsRisk differenceTarget populationTreatment assignmentThree-drug armInverse probability weightsACTG A5095Protocol effectUS HIVHazard ratioRandomized trialsInverse oddsTreatment protocolRegimenUS individualsHIVProtocol estimatesTrialsProtocol analysis
2023
Optimizing Treatment for Human Immunodeficiency Virus to Improve Clinical Outcomes Using Precision Medicine
Jetsupphasuk M, Hudgens M, Lu H, Cole S, Edwards J, Adimora A, Althoff K, Silverberg M, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Moore R, Lang R, Gebo K, Rabkin C, Eron J. Optimizing Treatment for Human Immunodeficiency Virus to Improve Clinical Outcomes Using Precision Medicine. American Journal Of Epidemiology 2023, 192: 1341-1349. PMID: 36922393, PMCID: PMC10666965, DOI: 10.1093/aje/kwad057.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeHIVHIV InfectionsHumansPrecision MedicineReverse Transcriptase InhibitorsConceptsEfavirenz-based regimenAntiretroviral therapyPatient characteristicsComposite outcomeNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapySerious non-AIDS eventsHuman immunodeficiency virus (HIV) treatmentIntegrase strand transfer inhibitorsSame drug regimenBaseline patient characteristicsNon-AIDS eventsAbsolute risk reductionSubgroup of patientsHuman immunodeficiency virusIndividual patient characteristicsImmune deficiency syndromePrecision medicineStrand transfer inhibitorsCohort CollaborationCause mortalityDrug regimenClinical outcomesImmunodeficiency virusDeficiency syndrome
2021
Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy. AIDS 2021, 36: 277-286. PMID: 34934020, PMCID: PMC9048218, DOI: 10.1097/qad.0000000000003069.Peer-Reviewed Original ResearchConceptsEFV groupINSTI groupVirologic outcomesAntiretroviral therapyART initiationIntegrase inhibitor-based antiretroviral therapyNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapyInhibitor-based antiretroviral therapyLong-term virologic outcomesIntegrase strand transfer inhibitorsFirst ART regimenInitial ART regimensRapid virologic responseStrand transfer inhibitorsART regimenCohort CollaborationInitial regimensVirologic responseVirologic suppressionART regimensVirologic effectsTreat analysisHIV treatmentLong-term effects
2020
What we talk about when we talk about durable viral suppression.
Diepstra K, Lu H, McManus K, Rogawski McQuade E, Rhodes A, Westreich D. What we talk about when we talk about durable viral suppression. AIDS 2020, 34: 1683-1686. PMID: 32732633, PMCID: PMC7845768, DOI: 10.1097/qad.0000000000002612.Peer-Reviewed Original Research
2019
What happens after HIV self-testing? Results from a longitudinal cohort of Chinese men who have sex with men
Tang W, Huang W, Lu H, Cao B, Wu D, Ong J, Fu H, Zhang Y, Yang B, Wang C, Ma W, Wei C, Tucker J. What happens after HIV self-testing? Results from a longitudinal cohort of Chinese men who have sex with men. BMC Infectious Diseases 2019, 19: 807. PMID: 31521123, PMCID: PMC6744670, DOI: 10.1186/s12879-019-4455-8.Peer-Reviewed Original ResearchConceptsFacility-based HIV testingConsistent condom useHIV testingHIV prevention servicesCondom usePrevention servicesStudy periodFacility-based testingMore implementation researchLongitudinal cohort dataHIV testIntervention trialsLongitudinal cohortChinese MSMChinese menHIVSociodemographic informationHIVSTSecondary analysisCohort dataHIVST resultsMost menImplementation researchLinear mixed modelsMenLeading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China
Wu D, Tang W, Lu H, Zhang T, Cao B, Ong J, Lee A, Liu C, Huang W, Fu R, Li K, Pan S, Zhang Y, Fu H, Wei C, Tucker J. Leading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China. Journal Of Medical Internet Research 2019, 21: e10171. PMID: 30664490, PMCID: PMC6360381, DOI: 10.2196/10171.Peer-Reviewed Original ResearchConceptsSyphilis testingMale sex partnersHealth influencersSTI informationSex partnersSociodemographic characteristicsSyphilis testing ratesUnknown HIV statusSexual behaviorInternet-Using MenLogistic regression modelsHealthy HIVHigh HIVHIV testingHIV statusMSM populationHigher oddsCondomless sexHIVTesting ratesHealthy behaviorsLeast college educationWeb-based surveyMale partnersMost menRecalling, Sharing and Participating in a Social Media Intervention Promoting HIV Testing: A Longitudinal Analysis of HIV Testing Among MSM in China
Cao B, Saha P, Leuba S, Lu H, Tang W, Wu D, Ong J, Liu C, Fu R, Wei C, Tucker J. Recalling, Sharing and Participating in a Social Media Intervention Promoting HIV Testing: A Longitudinal Analysis of HIV Testing Among MSM in China. AIDS And Behavior 2019, 23: 1240-1249. PMID: 30632008, PMCID: PMC6511317, DOI: 10.1007/s10461-019-02392-0.Peer-Reviewed Original Research
2018
Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial
Tang W, Wei C, Cao B, Wu D, Li K, Lu H, Ma W, Kang D, Li H, Liao M, Mollan K, Hudgens M, Liu C, Huang W, Liu A, Zhang Y, Smith M, Mitchell K, Ong J, Fu H, Vickerman P, Yang L, Wang C, Zheng H, Yang B, Tucker J. Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial. PLOS Medicine 2018, 15: e1002645. PMID: 30153265, PMCID: PMC6112627, DOI: 10.1371/journal.pmed.1002645.Peer-Reviewed Original ResearchConceptsHIV testing servicesFacility-based HIV testingHIV testingHIV testSecondary outcomesSyphilis testingIntervention periodClosed cohortWedge clusterCommunity-based HIV testing servicesCondom useSelf-reported HIV testingTesting servicesControl periodHIV testing campaignsHIV testing dataHIV testing ratesHIV testing strategiesHIV testing uptakeSubset of menHIV testing interventionsMiddle-income countriesPrimary outcomeTreat analysisCluster RCT