Featured Publications
Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada. Clinical Infectious Diseases 2020, 73: e1408-e1414. PMID: 32780095, PMCID: PMC8492356, DOI: 10.1093/cid/ciaa1037.Peer-Reviewed Original ResearchMeSH KeywordsAdultCanadaCohort StudiesHIVHIV InfectionsHIV Integrase InhibitorsHumansTreatment OutcomeUnited StatesConceptsIntegrase strand transfer inhibitorsHuman immunodeficiency virusHazard ratioEFV groupAntiretroviral therapyStrand transfer inhibitorsClinical outcomesRisk differenceINSTI groupComposite outcomeImmunodeficiency virusClinical effectivenessNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapyEnd-stage liver diseaseLong-term clinical effectivenessEnd-stage renal diseaseLong-term clinical outcomesComposite clinical outcomeFirst ART regimenInitial ART regimensAdverse clinical outcomesModern antiretroviral therapyTransfer inhibitorsAcute myocardial infarction
2021
Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy. AIDS 2021, 36: 277-286. PMID: 34934020, PMCID: PMC9048218, DOI: 10.1097/qad.0000000000003069.Peer-Reviewed Original ResearchConceptsEFV groupINSTI groupVirologic outcomesAntiretroviral therapyART initiationIntegrase inhibitor-based antiretroviral therapyNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapyInhibitor-based antiretroviral therapyLong-term virologic outcomesIntegrase strand transfer inhibitorsFirst ART regimenInitial ART regimensRapid virologic responseStrand transfer inhibitorsART regimenCohort CollaborationInitial regimensVirologic responseVirologic suppressionART regimensVirologic effectsTreat analysisHIV treatmentLong-term effects
2018
Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial
Tang W, Wei C, Cao B, Wu D, Li K, Lu H, Ma W, Kang D, Li H, Liao M, Mollan K, Hudgens M, Liu C, Huang W, Liu A, Zhang Y, Smith M, Mitchell K, Ong J, Fu H, Vickerman P, Yang L, Wang C, Zheng H, Yang B, Tucker J. Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial. PLOS Medicine 2018, 15: e1002645. PMID: 30153265, PMCID: PMC6112627, DOI: 10.1371/journal.pmed.1002645.Peer-Reviewed Original ResearchConceptsHIV testing servicesFacility-based HIV testingHIV testingHIV testSecondary outcomesSyphilis testingIntervention periodClosed cohortWedge clusterCommunity-based HIV testing servicesCondom useSelf-reported HIV testingTesting servicesControl periodHIV testing campaignsHIV testing dataHIV testing ratesHIV testing strategiesHIV testing uptakeSubset of menHIV testing interventionsMiddle-income countriesPrimary outcomeTreat analysisCluster RCT
2017
Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults
Gross A, Lu H, Meoni L, Gallo J, Schrack J, Sharrett A. Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults. Journal Of Alzheimer's Disease 2017, 59: 1349-1358. PMID: 28759969, DOI: 10.3233/jad-170290.Peer-Reviewed Original ResearchConceptsPhysical activityCox proportional hazards modelLate-life cognitionMidlife physical activityPhysical activity measuresProportional hazards modelOnset of dementiaCognitive testsNormal older adultsCross-sectional findingsRandomized trialsRegular exerciseMetabolic equivalentsDementia onsetObservational studyHazards modelDementiaActivity measuresCognitive healthOlder adultsBetter cognitionCross-sectional dataLater lifeCohortNull findings