Featured Publications
Generalizing the per-protocol treatment effect: The case of ACTG A5095
Lu H, Cole S, Hall H, Schisterman E, Breger T, Edwards J, Westreich D. Generalizing the per-protocol treatment effect: The case of ACTG A5095. Clinical Trials 2018, 16: 52-62. PMID: 30326736, PMCID: PMC6693502, DOI: 10.1177/1740774518806311.Peer-Reviewed Original ResearchConceptsFour-drug antiretroviral regimenThree-drug regimenConventional intentionAntiretroviral regimenVirologic failureTreat comparisonProtocol deviationsRisk differenceTarget populationTreatment assignmentThree-drug armInverse probability weightsACTG A5095Protocol effectUS HIVHazard ratioRandomized trialsInverse oddsTreatment protocolRegimenUS individualsHIVProtocol estimatesTrialsProtocol analysis
2017
Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults
Gross A, Lu H, Meoni L, Gallo J, Schrack J, Sharrett A. Physical Activity in Midlife is not Associated with Cognitive Health in Later Life Among Cognitively Normal Older Adults. Journal Of Alzheimer's Disease 2017, 59: 1349-1358. PMID: 28759969, DOI: 10.3233/jad-170290.Peer-Reviewed Original ResearchConceptsPhysical activityCox proportional hazards modelLate-life cognitionMidlife physical activityPhysical activity measuresProportional hazards modelOnset of dementiaCognitive testsNormal older adultsCross-sectional findingsRandomized trialsRegular exerciseMetabolic equivalentsDementia onsetObservational studyHazards modelDementiaActivity measuresCognitive healthOlder adultsBetter cognitionCross-sectional dataLater lifeCohortNull findings