2012
CFTR dysfunction predisposes to fibrotic liver disease in a murine model
Martin C, Zaman M, Ketwaroo G, Bhutta A, Coronel E, Popov Y, Schuppan D, Freedman S. CFTR dysfunction predisposes to fibrotic liver disease in a murine model. AJP Gastrointestinal And Liver Physiology 2012, 303: g474-g481. PMID: 22679000, PMCID: PMC3423138, DOI: 10.1152/ajpgi.00055.2012.Peer-Reviewed Original ResearchConceptsCystic fibrosis liver diseaseDextran sodium sulfateBile duct injuryPrimary sclerosing cholangitisDuct injuryFibrotic liver diseaseLiver diseaseSclerosing cholangitisCFTR dysfunctionGrowth factorProgressive biliary fibrosisInduction of colitisMononuclear cell inflammationBile duct proliferationEvaluation of therapyWild-type littermatesSmooth muscle actinCFTR functionBiliary fibrosisUlcerative colitisDuct proliferationPeriductal fibrosisSubthreshold dosesPeriductular fibrosisLiver fibrosis
2011
Hepatitis C Virus Treatment in HIV
Chung R, Ketwaroo G. Hepatitis C Virus Treatment in HIV. 2011, 133-139. DOI: 10.1007/978-1-4419-1712-6_15.Peer-Reviewed Original ResearchLiver diseaseHepatitis C virus (HCV) treatmentActive antiretroviral therapyLiver-related mortalityC virus treatmentRate of fibrosisHepatitis C virusHIV coinfectionHIV-HCVAntiretroviral therapyOpportunistic infectionsC virusChronic conditionsVirus treatmentSignificant causeHIVHCVMortalityDiseaseCirrhosisMorbidityComplicationsPatientsFibrosisCoinfection