Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression
Malvi P, Janostiak R, Nagarajan A, Cai G, Wajapeyee N. Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression. PLOS Genetics 2019, 15: e1008439. PMID: 31589613, PMCID: PMC6797230, DOI: 10.1371/journal.pgen.1008439.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAdultAgedAnimalsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationDatasets as TopicDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGrowth Differentiation Factor 15HumansLungLung NeoplasmsMaleMiceMiddle AgedNeoplasm Recurrence, LocalPrognosisSurvival AnalysisThymidine KinaseTranscription FactorsXenograft Model Antitumor AssaysConceptsShort hairpin RNALUAD cellsMetastatic attributesRho GTPase activityMAP kinase pathwayEctopic expressionGTPase activityTranscriptional overexpressionKinase pathwayKinase 1Cancer cell growthGenetic knockdownProfiling-based approachDifferentiation factor 15Hairpin RNALung adenocarcinoma patientsLung cancer growthCell growthLUAD therapyDownstream mediatorLUAD tumorsLUAD growthKey hallmarksReduced expressionDependent manner