2024
Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts
Rivier C, Acosta J, Leasure A, Forman R, Sharma R, de Havenon A, Spatz E, Inzucchi S, Kernan W, Falcone G, Sheth K. Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts. Journal Of The American Heart Association 2024, 13: e033322. PMID: 38639369, PMCID: PMC11179946, DOI: 10.1161/jaha.123.033322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureCross-Sectional StudiesFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPractice Guidelines as TopicRisk AssessmentRisk FactorsSecondary PreventionStrokeUnited KingdomUnited StatesConceptsMyocardial infarctionPrevention scoreSecondary preventionImplementation of preventive therapyNational cohortUK BiobankAntiplatelet therapy useGuideline-directed therapyPrevention profilesBlood pressure controlAdherence to guideline-directed therapyLow-density lipoprotein controlNeighborhood deprivation levelHistory of strokeVascular risk profileStatin useAntiplatelet useTherapy usePreventive therapyComparison to participantsPrevention criteriaCross-sectional analysisBlood pressurePatientsPressure control
2021
Genetic determinants of LDL cholesterol and risk of intracerebral haemorrhage
Szejko N, Kirsch E, Falcone GJ. Genetic determinants of LDL cholesterol and risk of intracerebral haemorrhage. Current Opinion In Lipidology 2021, 32: 244-248. PMID: 34010223, PMCID: PMC10273781, DOI: 10.1097/mol.0000000000000761.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageCholesterol, LDLClinical Trials as TopicHumansHydroxymethylglutaryl-CoA Reductase InhibitorsObservational Studies as TopicConceptsRisk of ICHIntracerebral hemorrhageLDL levelsLDL cholesterolInverse associationClinical trialsLipid levelsObservational studyCerebral small vessel diseaseWhite matter hyperintensity volumeLDL cholesterol levelsLow LDL levelsNontraumatic intracerebral hemorrhageSmall vessel diseaseElevated LDL levelsElevated lipid levelsVessel diseaseCholesterol levelsHigh burdenHyperintensity volumeHigh riskRole of lipidsHemorrhageStatinsRisk
2020
Statin treatment and cerebral microbleeds: A systematic review and meta-analysis
Katsanos AH, Lioutas VA, Charidimou A, Catanese L, Ng KKH, Perera K, Boasquevisque D, Falcone GJ, Sheth KN, Romero JR, Tsivgoulis G, Smith EE, Sharma M, Selim MH, Shoamanesh A, Initiative T. Statin treatment and cerebral microbleeds: A systematic review and meta-analysis. Journal Of The Neurological Sciences 2020, 420: 117224. PMID: 33183779, DOI: 10.1016/j.jns.2020.117224.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageCross-Sectional StudiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMagnetic Resonance ImagingStrokeConceptsCMB presenceStatin useCurrent statin useStatin treatmentRandomized-controlled clinical trialSpontaneous intracerebral hemorrhageRandom-effects modelCMB prevalenceIschemic strokeHemorrhagic strokeAdjusted analysisCerebral microbleedsIntracerebral hemorrhageRandomized trialsUnadjusted analysesClinical trialsEligible studiesAncillary studiesObservational studyPooled estimatesGeneral populationSystematic reviewUnadjusted probabilitySystematic searchCross-sectional data
2018
Cholesterol levels, statins, and spontaneous intracerebral hemorrhage
Falcone GJ, Gurol ME. Cholesterol levels, statins, and spontaneous intracerebral hemorrhage. Neurology 2018, 91: 197-198. PMID: 29970403, DOI: 10.1212/wnl.0000000000005898.Peer-Reviewed Original ResearchCerebral HemorrhageCholesterolCohort StudiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsRisk Factors
2013
Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage
Woo D, Deka R, Falcone GJ, Flaherty ML, Haverbusch M, Martini SR, Greenberg SM, Ayres AM, Sauerbeck L, Kissela BM, Kleindorfer DO, Moomaw CJ, Anderson CD, Broderick JP, Rosand J, Langefeld CD, Woo JG. Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage. Stroke 2013, 44: 3013-3017. PMID: 24008570, PMCID: PMC3873717, DOI: 10.1161/strokeaha.113.001304.Peer-Reviewed Original ResearchMeSH KeywordsAgedApolipoproteins ECase-Control StudiesCerebral HemorrhageFemaleGenotypeHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedProspective StudiesRisk FactorsConceptsRisk of ICHLobar intracerebral hemorrhageStatin useIntracerebral hemorrhageReplication cohortICH casesAssociation of hypercholesterolemiaHemorrhagic Stroke studyNonlobar intracerebral hemorrhageCase-control studyApolipoprotein E genotypeFisher's exact testEnvironmental risk factorsBreslow-Day testHemorrhagic strokeStroke StudyRisk factorsClinical changesE4 genotypeAPOE polymorphismE genotypeApolipoprotein EDiscovery cohortHigh riskLower riskWarfarin and Statins are Associated with Hematoma Volume in Primary Infratentorial Intracerebral Hemorrhage
Falcone GJ, Brouwers HB, Biffi A, Anderson CD, Battey TW, Ayres AM, Vashkevich A, Schwab KM, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Warfarin and Statins are Associated with Hematoma Volume in Primary Infratentorial Intracerebral Hemorrhage. Neurocritical Care 2013, 21: 192-199. PMID: 23839705, PMCID: PMC4107188, DOI: 10.1007/s12028-013-9839-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsBrain Stem Hemorrhage, TraumaticCerebellar DiseasesCerebral HemorrhageFemaleHematomaHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedRadiographyRetrospective StudiesTreatment OutcomeWarfarinConceptsInfratentorial intracerebral hemorrhageIntracerebral hemorrhageICH volumeSurgical evacuationHematoma volumeBrainstem ICHSingle-center studySupratentorial intracerebral hemorrhageWarfarin treatmentStatin treatmentEmergency departmentICH casesRetrospective analysisCT scanLogistic regressionWarfarinICH subjectsLimited dataHemorrhageStatinsFurther studiesComputer-assisted methodTreatmentInverse relationLinear regression