2016
CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage
Morotti A, Jessel MJ, Brouwers HB, Falcone GJ, Schwab K, Ayres AM, Vashkevich A, Anderson CD, Viswanathan A, Greenberg SM, Gurol ME, Romero JM, Rosand J, Goldstein JN. CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage. Neurocritical Care 2016, 25: 79-85. PMID: 26759226, PMCID: PMC4940347, DOI: 10.1007/s12028-016-0241-2.Peer-Reviewed Original ResearchConceptsPrimary pontine hemorrhagePositive predictive valueSupratentorial intracerebral hemorrhageIntracerebral hemorrhageHematoma expansionHospital mortalitySpot signNegative predictive valuePredictive valueNon-contrast CT scanCT angiography spot signAbsolute hematoma growthBrainstem ICHTomography angiography spot signConsecutive ICH patientsComputer-assisted volumetric analysisSpot sign presenceNegative likelihood ratioCTA spot signCollected cohortICH patientsPontine hemorrhagePPH casesHematoma growthHematoma volume
2015
Rate of Contrast Extravasation on Computed Tomographic Angiography Predicts Hematoma Expansion and Mortality in Primary Intracerebral Hemorrhage
Brouwers HB, Battey TW, Musial HH, Ciura VA, Falcone GJ, Ayres AM, Vashkevich A, Schwab K, Viswanathan A, Anderson CD, Greenberg SM, Pomerantz SR, Ortiz CJ, Goldstein JN, Gonzalez RG, Rosand J, Romero JM. Rate of Contrast Extravasation on Computed Tomographic Angiography Predicts Hematoma Expansion and Mortality in Primary Intracerebral Hemorrhage. Stroke 2015, 46: 2498-2503. PMID: 26243220, PMCID: PMC4550492, DOI: 10.1161/strokeaha.115.009659.Peer-Reviewed Original ResearchConceptsPrimary intracerebral hemorrhageHematoma expansionContrast extravasationIntracerebral hemorrhageSpot signExtravasation rateTomographic angiographyConsecutive intracerebral hemorrhage patientsML/minContrast extravasation rateAcute intracerebral hemorrhageIntracerebral hemorrhage patientsMultivariable logistic regressionRate of bleedingIntracerebral hemorrhage volumeSpot sign presenceHospital mortalityMultivariable analysisHemorrhage patientsPostcontrast CTHemorrhage volumeSemiautomated softwareMortalityLogistic regressionHemorrhage
2014
CT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgery
Brouwers HB, Raffeld MR, van Nieuwenhuizen KM, Falcone GJ, Ayres AM, McNamara KA, Schwab K, Romero JM, Velthuis BK, Viswanathan A, Greenberg SM, Ogilvy CS, van der Zwan A, Rinkel GJ, Goldstein JN, Klijn CJ, Rosand J. CT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgery. Neurology 2014, 83: 883-889. PMID: 25098540, PMCID: PMC4153853, DOI: 10.1212/wnl.0000000000000747.Peer-Reviewed Original ResearchConceptsPostoperative rebleedingIntracerebral hemorrhageSpontaneous intracerebral hemorrhageSpot signActive bleedingHematoma evacuationIntraoperative bleedingCase fatalityICH volumeCT angiography spot signBrainstem ICHOnly independent markerSurgical hematoma evacuationSpontaneous ICH patientsMultivariable logistic regressionConsecutive spontaneous ICH patientsFuture surgical trialsSpot sign presenceCTA spot signAntiplatelet usePostoperative bleedingResidual hematomaICH patientsFemale sexSurgical trialsRisk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared
Radmanesh F, Falcone GJ, Anderson CD, Battey TW, Ayres AM, Vashkevich A, McNamara KA, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Goldstein JN, Rosand J, Brouwers HB. Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared. Stroke 2014, 45: 1833-1835. PMID: 24876264, PMCID: PMC4116606, DOI: 10.1161/strokeaha.114.005276.Peer-Reviewed Original ResearchConceptsLobar intracerebral hemorrhageComputed tomography angiographyBaseline ICH volumeIntracerebral hemorrhagePrimary intracerebral hemorrhageSpot signTomography angiographyICH locationICH volumeMultivariable regressionChronic cerebral small vessel diseaseCerebral small vessel diseaseDeep intracerebral hemorrhageSmall vessel diseaseTomography angiography spot signLobar ICH patientsComputed tomography angiography spot signAvailable computed tomography angiographySpot sign presenceSymptom onsetICH patientsPoor outcomeVessel diseaseAcute manifestationsHematoma expansion
2012
CTA Spot Sign Predicts Hematoma Expansion in Patients with Delayed Presentation After Intracerebral Hemorrhage
Brouwers HB, Falcone GJ, McNamara KA, Ayres AM, Oleinik A, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Rosand J, Goldstein JN. CTA Spot Sign Predicts Hematoma Expansion in Patients with Delayed Presentation After Intracerebral Hemorrhage. Neurocritical Care 2012, 17: 421-428. PMID: 22878870, PMCID: PMC3707619, DOI: 10.1007/s12028-012-9765-2.Peer-Reviewed Original ResearchConceptsHematoma expansionSymptom onsetSpot signUnknown onset timeCTA spot signIntracerebral hemorrhageCT angiography spot signHematoma expansion ratesUnknown symptom onsetOnset timeAcute intracerebral hemorrhageMajority of patientsSymptom onset timeBackgroundHematoma expansionDelayed PresentationFollowup CTConsecutive patientsInitial CTClinical trialsNovel therapiesPatientsHemorrhageExperienced readersOnsetSigns