2012
Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior
Simon-Areces J, Dietrich MO, Hermes G, Garcia-Segura LM, Arevalo MA, Horvath TL. Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior. PLOS ONE 2012, 7: e42911. PMID: 22905184, PMCID: PMC3414493, DOI: 10.1371/journal.pone.0042911.Peer-Reviewed Original ResearchConceptsUCP2 expressionCellular stressHippocampal neuronsChemical inhibitionMitochondrial bioenergeticsNeuronal differentiationGenetic ablationNatural birthProtein 2Adult behaviorCell proliferationCritical roleAdult brainNeuronal numberExpressionBioenergeticsNeuronsBirthDifferentiationRegulationProliferationSynaptogenesisVitroNeuroprotectionHippocampus
2011
Identification of a Sporozoite-Specific Antigen from Toxoplasma gondii
Hill D, Coss C, Dubey J, Wroblewski K, Sautter M, Hosten T, Muñoz-Zanzi C, Mui E, Withers S, Boyer K, Hermes G, Coyne J, Jagdis F, Burnett A, McLeod P, Morton H, Robinson D, McLeod R. Identification of a Sporozoite-Specific Antigen from Toxoplasma gondii. Journal Of Parasitology 2011, 97: 328-337. PMID: 21506817, PMCID: PMC3684278, DOI: 10.1645/ge-2782.1.Peer-Reviewed Original ResearchConceptsDetectable antibodiesToxoplasma gondiiEarly T. gondii infectionWestern blotT. gondii infectionRoute of infectionT. gondii sporozoitesAgents of infectionAcute stageChronic stageGondii infectionSerum antibodiesEpidemiological dataUninfected individualsInfection routeSerological assaysInfectionSporozoite-specific proteinsPrevious exposureAntibodiesReduction of riskAnimal infectionsPredominant routeDifference gel electrophoresisTandem mass spectroscopy
2008
Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection
Hermes G, Ajioka JW, Kelly KA, Mui E, Roberts F, Kasza K, Mayr T, Kirisits MJ, Wollmann R, Ferguson D, Roberts CW, Hwang JH, Trendler T, Kennan RP, Suzuki Y, Reardon C, Hickey WF, Chen L, McLeod R. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. Journal Of Neuroinflammation 2008, 5: 48. PMID: 18947414, PMCID: PMC2588578, DOI: 10.1186/1742-2094-5-48.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAtrophyBehavior, AnimalBiomarkersBrainCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChronic DiseaseDisease Models, AnimalEncephalitisFemaleLateral VentriclesMagnetic Resonance ImagingMiceMicrogliaNerve DegenerationNerve Tissue ProteinsNeuronsToxoplasmaToxoplasmosis, CerebralConceptsT. gondii infectionAqueduct of SylviusPerivascular inflammationVentricular dilatationGondii infectionResistant miceInflammatory cellsBrain weightBrain parenchymaBrain MRIBehavioral abnormalitiesChronic T. gondii infectionLower brain weightPersistent brain infectionBrains of micePD-1LResultsTwelve monthsNeurologic findingsNeurological deficitsNeuronal injuryStudy of markersNeurologic functionNeuronal damageBrain infectionFree tachyzoites