Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies
Hermes G, Sanacora G. Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies. 2016, 73-98. DOI: 10.1007/978-3-319-42925-0_6.Peer-Reviewed Original ResearchAntidepressant activityPreclinical studiesAntidepressant actionKetamine's mechanismPreclinical literatureRodent modelsRapid onsetBrain-derived neurotrophic factor (BDNF) expressionBehavioral effectsClassic antidepressant drugsRapid antidepressant activityNeurotrophic factor expressionChronic stressor exposureReceptor-targeted drugsNovel drug developmentAntidepressant propertiesKetamine effectsClinical trialsAntidepressant drugsSynaptic plasticityReceptor activationClinical settingFactor expressionStressor exposureDurable effectsRole of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation
Hermes G, Nagy D, Waterson M, Zsarnovszky A, Varela L, Hajos M, Horvath TL. Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation. Molecular Metabolism 2016, 5: 415-421. PMID: 27257601, PMCID: PMC4877662, DOI: 10.1016/j.molmet.2016.04.002.Peer-Reviewed Original ResearchMouse modelSynaptic plasticityMental illnessUCP2 knockout miceNMDA receptor blockadeHigher brain regionsKO mouse modelMajor psychiatric illnessProtein 2 expressionHigher brain functionsReceptor blockadePsychiatric illnessNeuronal plasticityKnockout miceNeural transmissionCellular resilienceCortical activityBrain regionsProfound disorderBrain functionMitochondrial impairmentIllnessNetwork oscillationsMitochondrial functionProtein 2