Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhans
Rajagopalan G, Mangalam A, Sen M, Cheng S, Kudva Y, David C. Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhans. Autoimmunity 2007, 40: 169-179. PMID: 17453715, DOI: 10.1080/08916930701201083.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesDiabetes Mellitus, Type 1Granulocyte-Macrophage Colony-Stimulating FactorHLA-DQ AntigensInsulin-Secreting CellsMiceMice, TransgenicConceptsHLA-DQ8GM-CSFDQ8 miceAutoimmune diabetesHLA-DQ8 transgenic miceMarked mononuclear cell infiltrationPotent immunostimulatory cytokineSpontaneous autoimmune diabetesMononuclear cell infiltrationNOD genetic backgroundGranulocyte/macrophage-colony stimulating factorStrong HLA associationType 1 diabetesPolygenic autoimmune diseasesMacrophage-colony stimulating factorLiver of miceMacrophage colony-stimulating factorGranulocyte/macrophage colony-stimulating factorColony-stimulating factorHLA associationsImmunostimulatory cytokinesAutoimmune diseasesCell infiltrationBeta cellsTransgenic mice