A monomeric fab fragment capable of inducing CD3 conformational change increases T cell receptor reactivity to poorly immunogenic antigens (TUM2P.1020)
Hoffmann M, Parks C, Hansen M, Rajagopalan G, Pease L, Schrum A, Gil Pages D. A monomeric fab fragment capable of inducing CD3 conformational change increases T cell receptor reactivity to poorly immunogenic antigens (TUM2P.1020). The Journal Of Immunology 2015, 194: 69.17-69.17. DOI: 10.4049/jimmunol.194.supp.69.17.Peer-Reviewed Original ResearchTCR/CD3Conformational changesCD3 complexT cell responsesProductive T cell responsesT cellsMature T cellsImmunogenic antigensCell responsesTCR engagementT cell activationTCR/MHC interactionsElicit signalingAnti-melanoma responsePMHC ligandsTg T cellsContext of vaccinationMonovalent Fab fragmentsMonomeric Fab fragmentsFab fragmentsSignal 2Cell activationPeptide ligandsCellsMetastatic melanoma