Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial: Rationale and Design
Sheth KN, Elm JJ, Beslow LA, Sze GK, Kimberly WT. Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial: Rationale and Design. Neurocritical Care 2015, 24: 132-139. PMID: 26268138, DOI: 10.1007/s12028-015-0189-7.Peer-Reviewed Original ResearchConceptsAdverse eventsCerebral edemaContinuous infusionHigh riskAnterior circulation ischemic strokeDiffusion-weighted image (DWI) lesionsAnterior circulation infarctionLarge territory infarctionMalignant cerebral edemaPrimary efficacy outcomeSerious adverse eventsLarge hemispheric strokeYears of ageStudy infusionEfficacy outcomesTerritory infarctionIschemic strokeNeurological deteriorationRankin ScaleSymptom onsetDecompressive craniectomyMulticenter trialBrain edemaHemispheric strokeStroke trials