1987
Treatment of Lyme disease
Steere A, Green J, Hutchinson G, Rahn D, Pachner A, Schoen R, Sigal L, Taylor E, Malawista S. Treatment of Lyme disease. International Journal Of Medical Microbiology 1987, 263: 352-356. PMID: 3109144, DOI: 10.1016/s0176-6724(87)80092-5.Peer-Reviewed Original ResearchConceptsPenicillin-treated patientsLyme diseaseHigh-dose intravenous penicillinAttacks of arthritisIntravenous penicillin GHalf of patientsMajor late complicationsEarly Lyme diseaseIntramuscular benzathine penicillinIntravenous penicillinLate complicationsAntibiotic therapyArthritis patientsBenzathine penicillinMotor deficitsNeurologic abnormalitiesLate diseaseLate symptomsPatientsPhenoxymethyl penicillinAntibiotic agentsComplete recoveryDiseasePenicillin GArthritis
1983
Treatment of the early manifestations of Lyme disease.
Steere AC, Hutchinson GJ, Rahn DW, Sigal LH, Craft JE, DeSanna ET, Malawista SE. Treatment of the early manifestations of Lyme disease. Annals Of Internal Medicine 1983, 99: 22-6. PMID: 6407378, DOI: 10.7326/0003-4819-99-1-22.Peer-Reviewed Original ResearchConceptsEarly Lyme diseaseAdult patientsLyme diseaseMajor late complicationsPenicillin-treated patientsTetracycline-treated patientsAntibiotic regimensLate complicationsMajor complicationsMusculoskeletal painInitial severityLate symptomsEffective drugsPatientsEarly manifestationAntibiotic agentsComplicationsDiseaseSymptomsErythromycinPenicillinTetracyclinePainRegimensHeadache