2018
PD‐L1 methylation regulates PD‐L1 expression and is associated with melanoma survival
Micevic G, Thakral D, McGeary M, Bosenberg M. PD‐L1 methylation regulates PD‐L1 expression and is associated with melanoma survival. Pigment Cell & Melanoma Research 2018, 32: 435-440. PMID: 30343532, PMCID: PMC6475614, DOI: 10.1111/pcmr.12745.Peer-Reviewed Original ResearchConceptsPD-L1 expressionDNA methylationPD-1/PD-L1 immune checkpointIndependent survival prognostic factorPD-L1 promoter methylationPD-L1 immune checkpointSurvival prognostic factorsPD-L1 promoterPromoter DNA methylationOverall survivalImmune checkpointsPrognostic factorsMelanoma patientsMelanoma survivalEpigenetic mechanismsTranscriptional phenotypeClinical importanceMelanomaCpG lociMethylationPromoter methylationSurvivalTherapeutic applicationsExpressionPatients
2016
Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma
Chen F, Zhang Y, Şenbabaoğlu Y, Ciriello G, Yang L, Reznik E, Shuch B, Micevic G, De Velasco G, Shinbrot E, Noble MS, Lu Y, Covington KR, Xi L, Drummond JA, Muzny D, Kang H, Lee J, Tamboli P, Reuter V, Shelley CS, Kaipparettu BA, Bottaro DP, Godwin AK, Gibbs RA, Getz G, Kucherlapati R, Park PJ, Sander C, Henske EP, Zhou JH, Kwiatkowski DJ, Ho TH, Choueiri TK, Hsieh JJ, Akbani R, Mills GB, Hakimi AA, Wheeler DA, Creighton CJ. Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma. Cell Reports 2016, 14: 2476-2489. PMID: 26947078, PMCID: PMC4794376, DOI: 10.1016/j.celrep.2016.02.024.Peer-Reviewed Original ResearchMeSH KeywordsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCarcinoma, Renal CellChromatinGene Expression ProfilingGenomicsHumansKidney NeoplasmsMicroRNAsMutationPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, MessengerSignal TransductionSurvival RateTOR Serine-Threonine KinasesConceptsRenal cell carcinomaMajor genomic subtypesChromatin modifier genesComprehensive molecular characterizationGenomic subtypesAggressive clear cell renal cell carcinomaCell carcinomaGene fusionsModifier genesMolecular characterizationMolecular signaturesClear cell renal cell carcinomaCell renal cell carcinomaSpecific pathwaysPapillary renal cell carcinomaImmune checkpoint markersT-cell infiltratesMolecular changesTFE3 gene fusionsSite of originCell infiltrateCheckpoint markersHistologic typePatient survivalDisease subsets