RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci
Vohhodina J, Toomire KJ, Petit SA, Micevic G, Kumari G, Botchkarev VV, Li Z, Livingston DM, Hu Y. RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 2084-2091. PMID: 31932421, PMCID: PMC6995001, DOI: 10.1073/pnas.1908003117.Peer-Reviewed Original ResearchConceptsHomologous recombination-mediated repairNuclear fociRecombination-mediated repairDNA repair fociPoly ADP-ribosylationProtein RAP80Chromatin structureChromosome integrityBRCA1 complexGenome disordersRepair fociRAP80Intracellular developmentPresence of BRCA1C complexActivity promotesSimultaneous lossBRCA1Complex formationNormal interactionComplexesPARsylationDNARibosylationChromosomal disorders