2000
Sex Differences in Inferior Parietal Lobule Volume in Schizophrenia
Frederikse M, Lu A, Aylward E, Barta P, Sharma T, Pearlson G. Sex Differences in Inferior Parietal Lobule Volume in Schizophrenia. American Journal Of Psychiatry 2000, 157: 422-427. PMID: 10698819, DOI: 10.1176/appi.ajp.157.3.422.Peer-Reviewed Original ResearchConceptsGray matter volumeLobule volumesFemale subjectsSchizophrenic patientsMatter volumeMale subjectsFemale schizophrenic subjectsSex differencesClinical disease expressionMale schizophrenic patientsAssociation cortical regionsFemale schizophrenic patientsHealthy female subjectsHealthy male subjectsPathophysiology of schizophreniaVolumetric sex differencesInferior parietal lobuleCortical regionsSchizophrenic subjectsParietal lobuleDisease expressionPatientsSchizophreniaSubjectsMagnetic resonanceElucidating the contributions of processing speed, executive ability, and frontal lobe volume to normal age-related differences in fluid intelligence
SCHRETLEN D, PEARLSON G, ANTHONY J, AYLWARD E, AUGUSTINE A, DAVIS A, BARTA P. Elucidating the contributions of processing speed, executive ability, and frontal lobe volume to normal age-related differences in fluid intelligence. Journal Of The International Neuropsychological Society 2000, 6: 52-61. PMID: 10761367, DOI: 10.1017/s1355617700611062.Peer-Reviewed Original ResearchConceptsPerceptual comparison speedFluid intelligenceExecutive abilitiesFrontal lobe volumeProcessing speedProcessing speed theorySimple processing speedHierarchical multiple regression analysisComparison speedFrontal brain structuresLobe volumeAge-related differencesAge-related declineNormal age-related differencesCognitive agingRegional brain volumesSpeed theoryMultiple regression analysisBrain structuresIntelligenceAge-related variationsBrain volumeNormal adultsMagnetic resonance imagingSame decline
1997
Basal ganglia volume in adults with Down syndrome
Aylward E, Li Q, Habbak R, Warren A, Pulsifer M, Barta P, Jerram M, Pearlson G. Basal ganglia volume in adults with Down syndrome. Psychiatry Research 1997, 74: 73-82. PMID: 9204510, DOI: 10.1016/s0925-4927(97)00011-5.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesGanglia volumesDS subjectsBasal gangliaDown syndromeControl subjectsDementia statusNeuropsychological test performanceBrain volumeSmaller total brain volumeVolumes of caudateTotal brain volumeBasal ganglia abnormalitiesOverall brain volumeLarger putamen volumesTotal brainGlobus pallidusPutamen volumeNormal individualsGangliaTest performanceNeuropsychological testsSignificant correlationSyndromeAge
1996
Eye Movements and Psychopathology in Schizophrenia and Bipolar Disorder
TIEN A, ROSS D, PEARLSON G, STRAUSS M. Eye Movements and Psychopathology in Schizophrenia and Bipolar Disorder. The Journal Of Nervous And Mental Disease 1996, 184: 331-338. PMID: 8642381, DOI: 10.1097/00005053-199606000-00001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAttentionBipolar DisorderEye MovementsFemaleHumansIntelligence TestsMaleMiddle AgedMultivariate AnalysisNeuropsychological TestsPsychiatric Status Rating ScalesPursuit, SmoothReaction TimeRegression AnalysisSaccadesSchizophreniaSchizophrenic PsychologySex FactorsVisual Perception
1992
Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease
Harris G, Pearlson G, Peyser C, Aylward E, Roberts J, Barta P, Chase G, Folstein S. Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease. Annals Of Neurology 1992, 31: 69-75. PMID: 1531910, DOI: 10.1002/ana.410310113.Peer-Reviewed Original ResearchConceptsMild Huntington's diseaseBicaudate ratioCaudate atrophyHuntington's diseaseHD patientsControl subjectsCaudate volumePutamen volumeSex-matched control subjectsNeurological examination scoresPutamen volume reductionsCharacteristic pathological featuresModerate Huntington's diseaseMagnetic resonance imagingCaudate changesNeostriatal atrophyNeuronal lossNeuroradiological studiesComputerized image analysis systemPathological featuresGreater atrophyBrain abnormalitiesCaudate nucleusAtrophyPatients
1991
Suprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease
Aylward E, Karagiozis H, Pearlson G, Folstein M. Suprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease. Journal Of Psychiatric Research 1991, 25: 31-47. PMID: 1827501, DOI: 10.1016/0022-3956(91)90014-2.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseSuprasellar cisternDisease patientsAD patientsTemporal lobeCognitive statusHuntington's diseaseRespective age-matched controlsBasal forebrain areasAge-matched controlsHuntington's disease patientsForebrain areasEntorhinal cortexCognitive declinePatientsDiseaseBrain widthLobeHDStatusAtrophyDementiaPerceptual ratingsCortex
1988
Late-Onset Schizophrenia Studying Clinical Validity
V.Jeste D, Harris M, Pearlson G, Rabins P, Lesser I, Miller B, Coles C, Yassa R. Late-Onset Schizophrenia Studying Clinical Validity. Psychiatric Clinics Of North America 1988, 11: 1-13. PMID: 3380754, DOI: 10.1016/s0193-953x(18)30513-6.Peer-Reviewed Original ResearchConceptsLate-onset schizophreniaSchizophrenic patientsYoung schizophrenic patientsClinical characteristicsChronic courseAge 45Onset schizophreniaParanoid typeClinical validityAuditory hallucinationsLow dosesBizarre delusionsSchizophreniaPatientsRelevant literatureNeurolepticsIllnessDosesHallucinationsThe Late-Onset Psychoses Possible Risk Factors
Pearlson G, Rabins P. The Late-Onset Psychoses Possible Risk Factors. Psychiatric Clinics Of North America 1988, 11: 15-32. PMID: 3288978, DOI: 10.1016/s0193-953x(18)30514-8.Peer-Reviewed Original Research
1987
Increased ventricle-to-brain ratio in late-onset schizophrenia
Rabins P, Pearlson G, Jayaram G, Steele C, Tune L. Increased ventricle-to-brain ratio in late-onset schizophrenia. American Journal Of Psychiatry 1987, 144: 1216-1218. PMID: 3631322, DOI: 10.1176/ajp.144.9.1216.Peer-Reviewed Original Research
1985
Symptomatic, Familial, Perinatal, and Social Correlates of Computerized Axial Tomography (CAT) Changes in Schizophrenics and Bipolars
PEARLSON G, GARBACZ D, MOBERG P, AHN H, DEPAULO J. Symptomatic, Familial, Perinatal, and Social Correlates of Computerized Axial Tomography (CAT) Changes in Schizophrenics and Bipolars. The Journal Of Nervous And Mental Disease 1985, 173: 42-50. PMID: 3965611, DOI: 10.1097/00005053-198501000-00007.Peer-Reviewed Original ResearchConceptsVentricular enlargementFamily historyNegative symptomsComputerized axial tomography scanLateral ventricular enlargementAxial tomography scanPast psychiatric historyEarly brain damageMarked ventricular enlargementSubgroup of schizophrenicsPoor premorbid adjustmentLateral ventricularTomography changesBrain ratioPatient groupBrain damageTomography scanPsychiatric illnessPsychiatric historyBipolar patientsNormal controlsEarly onsetPatientsPremorbid adjustmentSignificant proportion