2023
Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains
Anderson J, Calhoun V, Pearlson G, Hawkins K, Stevens M. Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains. Developmental Cognitive Neuroscience 2023, 64: 101318. PMID: 37875033, PMCID: PMC10618425, DOI: 10.1016/j.dcn.2023.101318.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnisotropyBrainCognitionDiffusion Tensor ImagingExecutive FunctionHumansWhite MatterYoung AdultConceptsExecutive function domainsResponse inhibitionWhite matter microstructureLower response inhibitionStructure-cognition relationshipsEF abilitiesBehavioral performanceCognitive imbalanceNeurocognitive testsFunction domainTest performanceYoung adulthoodFractional anisotropyBrain changesAge 12Young adultsSS performanceWhite matter FA valuesGreater relianceWhite matter changesWhite matter microstructural differencesSubjects ages 12White matter skeletonIndependent componentsMultivariate associations
2019
Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late‐life depression
Emam H, Steffens DC, Pearlson G, Wang L. Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late‐life depression. International Journal Of Geriatric Psychiatry 2019, 34: 730-737. PMID: 30761621, PMCID: PMC6480406, DOI: 10.1002/gps.5079.Peer-Reviewed Original ResearchConceptsLate-life depressionSelective serotonin reuptake inhibitorsNonresponder groupFunctional connectivitySSRI responseMADRS scoresResting-state functional magnetic resonance imaging (fMRI) scansMontgomery-Åsberg Depression Rating ScaleMajor depressive disorder patientsPrefrontal cortexMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansSubgenual cingulate areaSerotonin reuptake inhibitorsDepressive disorder patientsAcute treatment responseResonance imaging scansDepression Rating ScaleLower functional connectivityHigher functional connectivityFalse discovery rate correctionResting-state activityDefault mode networkROI connectivityAntidepressant treatment
2015
Memory, executive, and multidomain subtle cognitive impairment
Toledo J, Bjerke M, Chen K, Rozycki M, Jack C, Weiner M, Arnold S, Reiman E, Davatzikos C, Shaw L, Trojanowski J, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Leon S, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Memory, executive, and multidomain subtle cognitive impairment. Neurology 2015, 85: 144-153. PMID: 26085606, PMCID: PMC4515043, DOI: 10.1212/wnl.0000000000001738.Peer-Reviewed Original ResearchConceptsCognitive impairmentAlzheimer's Disease Neuroimaging InitiativeDisease Neuroimaging InitiativeCSF Alzheimer's disease biomarkersDifferent clinical prognosesBiomarker signaturesAlzheimer's disease biomarkersCognitive impairment groupSubtle cognitive impairmentMemory complaint groupBrain atrophySingle ROISCI groupCN subjectsClinical prognosisHealthy controlsAtrophy patternsDementia stagesNeuroimaging biomarkersImpairment groupClinical cutoffComplaint groupPattern-based analysisADNI participantsSMC group
2010
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease
Wolk D, Dickerson B, Weiner M, Aiello M, Aisen P, Albert M, Alexander G, Anderson H, Anderson K, Apostolova L, Arnold S, Ashford W, Assaly M, Asthana S, Bandy D, Bartha R, Bates V, Beckett L, Bell K, Benincasa A, Bergman H, Bernick C, Bernstein M, Black S, Blank K, Borrie M, Brand C, Brewer J, Brown A, Burns J, Cairns N, Caldwell C, Capote H, Carlsson C, Carmichael O, Cellar J, Celmins D, Chen K, Chertkow H, Chowdhury M, Clark D, Connor D, Correia S, Crawford K, Dale A, de Leon M, De Santi S, DeCarli C, deToledo-Morrell L, DeVous M, Diaz-Arrastia R, Dolen S, Donohue M, Doody R, Doraiswamy P, Duara R, Englert J, Farlow M, Feldman H, Felmlee J, Fleisher A, Fletcher E, Foroud T, Foster N, Fox N, Frank R, Gamst A, Given C, Graff-Radford N, Green R, Griffith R, Grossman H, Hake A, Hardy P, Harvey D, Heidebrink J, Hendin B, Herring S, Honig L, Hosein C, Hsiung G, Hudson L, Ismail M, Jack C, Jacobson S, Jagust W, Jayam-Trouth A, Johnson K, Johnson H, Johnson N, Johnson K, Johnson K, Johnson S, Kachaturian Z, Karlawish J, Kataki M, Kaye J, Kertesz A, Killiany R, Kittur S, Koeppe R, Korecka M, Kornak J, Kozauer N, Lah J, Laubinger M, Lee V, Lee T, Lerner A, Levey A, Longmire C, Lopez O, Lord J, Lu P, MacAvoy M, Malloy P, Marson D, Martin-Cook K, Martinez W, Marzloff G, Mathis C, Mc-Adams-Ortiz C, Mesulam M, Miller B, Mintun M, Mintzer J, Molchan S, Montine T, Morris J, Mulnard R, Munic D, Nair A, Neu S, Nguyen D, Norbash A, Oakley M, Obisesan T, Ogrocki P, Ott B, Parfitt F, Pawluczyk S, Pearlson G, Petersen R, Petrella J, Potkin S, Potter W, Preda A, Quinn J, Rainka M, Reeder S, Reiman E, Rentz D, Reynolds B, Richard J, Roberts P, Rogers J, Rosen A, Rosen H, Rusinek H, Sabbagh M, Sadowsky C, Salloway S, Santulli R, Saykin A, Scharre D, Schneider L, Schneider S, Schuff N, Shah R, Shaw L, Shen L, Silverman D, Simpson D, Sink K, Smith C, Snyder P, Spann B, Sperling R, Spicer K, Stefanovic B, Stern Y, Stopa E, Tang C, Tariot P, Taylor-Reinwald L, Thai G, Thomas R, Thompson P, Tinklenberg J, Toga A, Tremont G, Trojanowki J, Trost D, Turner R, van Dyck C, Vanderswag H, Varon D, Villanueva-Meyer J, Villena T, Walter S, Wang P, Watkins F, Weiner M, Williamson J, Wolk D, Wu C, Zerrate M, Zimmerman. E. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 10256-10261. PMID: 20479234, PMCID: PMC2890481, DOI: 10.1073/pnas.1001412107.Peer-Reviewed Original ResearchConceptsMedial temporal lobe pathologyLarge-scale brain networksParticular cognitive domainsDomains of cognitionSpecific large-scale brain networksTemporal lobe pathologyDisease Neuroimaging InitiativeMild Alzheimer's diseaseExecutive controlLexical accessCognitive processesCognitive dissociationCognitive domainsDissociable effectsRegional cortical atrophyPoor memoryNeuroanatomic findingsPerformance deficitsMemory retentionBrain networksPotential confoundsCortical networksPsychometric testsRegional brain atrophyGreater impairment