1999
Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives — The Maudsley Family Study
Sharma T, Lancaster E, Sigmundsson T, Lewis S, Takei N, Gurling H, Barta P, Pearlson G, Murray R. Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives — The Maudsley Family Study. Schizophrenia Research 1999, 40: 111-120. PMID: 10593451, DOI: 10.1016/s0920-9964(99)00143-7.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsOccipitoparietal regionsControl subjectsNormal patternCortical regionsLack of asymmetryFamilial schizophrenic patientsNormal cerebral asymmetryHealthy control subjectsFirst-degree relativesObligate carriersCerebral asymmetryRegional brain volumesUnrelated control subjectsDegree relativesRight sensorimotorNormal brain asymmetryBrain volumeMaudsley Family StudyPatientsOccipital asymmetryUnaffected relativesSchizophreniaBrain asymmetryNormal asymmetry
1997
Small planum temporale volume in Down's syndrome: a volumetric MRI study
Frangou S, Aylward E, Warren A, Sharma T, Barta P, Pearlson G. Small planum temporale volume in Down's syndrome: a volumetric MRI study. American Journal Of Psychiatry 1997, 154: 1424-1429. PMID: 9326826, DOI: 10.1176/ajp.154.10.1424.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCerebral VentriclesDown SyndromeFemaleFunctional LateralityHumansLanguage TestsMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesTemporal LobeConceptsPlanum temporale volumeSuperior temporal gyrusDown syndromeTemporal gyrusSyndrome patientsBrain volumePlanum temporaleMagnetic resonance imaging (MRI) measuresCommunity-dwelling patientsStructural brain abnormalitiesVolumetric MRI studyTotal brain volumeDown syndrome patientsHealthy comparison subjectsWhole brain volumeVolumetric magnetic resonance imaging (MRI) measuresAnatomic substrateBrain abnormalitiesHealthy subjectsComparison subjectsMRI studiesVolume deficitsSyndromeGyrusImaging measures
1996
Eye Movements and Psychopathology in Schizophrenia and Bipolar Disorder
TIEN A, ROSS D, PEARLSON G, STRAUSS M. Eye Movements and Psychopathology in Schizophrenia and Bipolar Disorder. The Journal Of Nervous And Mental Disease 1996, 184: 331-338. PMID: 8642381, DOI: 10.1097/00005053-199606000-00001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAttentionBipolar DisorderEye MovementsFemaleHumansIntelligence TestsMaleMiddle AgedMultivariate AnalysisNeuropsychological TestsPsychiatric Status Rating ScalesPursuit, SmoothReaction TimeRegression AnalysisSaccadesSchizophreniaSchizophrenic PsychologySex FactorsVisual Perception
1995
Cingulate gyrus in schizophrenic patients and normal volunteers
Noga J, Aylward E, Barta P, Pearlson G. Cingulate gyrus in schizophrenic patients and normal volunteers. Psychiatry Research 1995, 61: 201-208. PMID: 8748465, DOI: 10.1016/0925-4927(95)02612-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingDominance, CerebralFemaleGyrus CinguliHumansMagnetic Resonance ImagingMaleNeurocognitive DisordersPsychiatric Status Rating ScalesReference ValuesSchizophreniaSchizophrenic PsychologyConceptsSeverity of hallucinationsCingulate gyrusNormal volunteersMagnetic resonance imaging sectionsPosterior cingulate gyrusPatient groupSchizophrenic patientsBrain volumeParental socioeconomic statusCingulate regionsPatientsCingulate structuresSocioeconomic statusInverse correlationGyrusInterrater reliabilityBonferroni correctionSchizophreniaSeverityVolunteersHallucinationsImaging sectionsLateral asymmetryGroupPosterior superior temporal gyrus in schizophrenia: grey matter changes and clinical correlates
Menon R, Barta P, Aylward E, Richards S, Vaughn D, Tien A, Harris G, Pearlson G. Posterior superior temporal gyrus in schizophrenia: grey matter changes and clinical correlates. Schizophrenia Research 1995, 16: 127-135. PMID: 7577766, DOI: 10.1016/0920-9964(94)00067-i.Peer-Reviewed Original ResearchIn Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder
Pearlson G, Wong D, Tune L, Ross C, Chase G, Links J, Dannals R, Wilson A, Ravert H, Wagner H, DePaulo J. In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder. JAMA Psychiatry 1995, 52: 471-477. PMID: 7771917, DOI: 10.1001/archpsyc.1995.03950180057008.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsBipolar disorderBmax valuesNonpsychotic patientsNormal controlsPsychotic symptomsPsychotic patientsAffective disordersPositron emission tomographic scansD2 dopamine receptor densityNeuroleptic-naive schizophrenic patientsPositron emission tomographic studiesDopamine receptor densityReceptor density valuesDSM-III criteriaPresent State ExaminationPresence of psychosisEmission tomographic studiesHigher Bmax valuesPsychotic bipolar disorderNeuroleptic medicationReceptor BmaxMood abnormalitiesReceptor valuesTomographic scan
1993
Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone
Tune L, Wong D, Pearlson G, Strauss M, Young T, Shaya E, Dannals R, Wilson A, Ravert H, Sapp J, Cooper T, Chase G, Wagner H. Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone. Psychiatry Research 1993, 49: 219-237. PMID: 7909948, DOI: 10.1016/0165-1781(93)90063-m.Peer-Reviewed Original ResearchConceptsPositron emission tomographySchizophrenic patientsBmax valuesEntire groupControl subjectsEmission tomographyDopamine D2 receptor densityNeuroleptic-free patientsDuration of illnessChronic schizophrenic patientsD2 receptor densityClinical characteristicsPatient populationReceptor abnormalitiesCorpus striatumClinical dataReceptor densityPatientsControl groupFunction of ageLate manifestationDifferent radioligandsFour-compartment modelSignificant differencesRadioligand
1991
Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography
Cascella N, Pearlson G, Wong D, Broussolle E, Nagoshi C, Margolin R, London E. Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography. The British Journal Of Psychiatry 1991, 159: 217-221. PMID: 1773237, DOI: 10.1192/bjp.159.2.217.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAtrophyBrainCerebral VentriclesEthanolFollow-Up StudiesHumansMalePsychiatric Status Rating ScalesPsychotropic DrugsSubstance-Related DisordersTomography, X-Ray ComputedConceptsSubstance abuseSulcal measuresCocaine useSulcal widthWider third ventriclesEffect of ageBrain atrophyBrain ratioChronic useComputerised tomographyThird ventricleNormal controlsAlcohol consumptionBrain morphologyAlcohol usePolydrug abusersSignificant predictorsAgeVentricleSeverityTomographyPositive correlationAbusePossible effectsVentricularSuprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease
Aylward E, Karagiozis H, Pearlson G, Folstein M. Suprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease. Journal Of Psychiatric Research 1991, 25: 31-47. PMID: 1827501, DOI: 10.1016/0022-3956(91)90014-2.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseSuprasellar cisternDisease patientsAD patientsTemporal lobeCognitive statusHuntington's diseaseRespective age-matched controlsBasal forebrain areasAge-matched controlsHuntington's disease patientsForebrain areasEntorhinal cortexCognitive declinePatientsDiseaseBrain widthLobeHDStatusAtrophyDementiaPerceptual ratingsCortex
1984
Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder
Pearlson G, Garbacz D, Breakey W, Ahn H, DePaulo J. Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Research 1984, 12: 1-9. PMID: 6589656, DOI: 10.1016/0165-1781(84)90133-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBipolar DisorderCerebral VentriclesFemaleHumansMalePsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologySocial AdjustmentTomography, X-Ray ComputedUnemployment
1983
Mood Change following Bilateral Hemisphere Brain Injury
Lipsey J, Robinson R, Pearlson G, Rao K, Price T. Mood Change following Bilateral Hemisphere Brain Injury. The British Journal Of Psychiatry 1983, 143: 266-273. PMID: 6626839, DOI: 10.1192/bjp.143.3.266.Peer-Reviewed Original ResearchConceptsHemisphere brain injuryFunctional physical impairmentBrain injuryCognitive impairmentPhysical impairmentLeft frontal lobe lesionFrontal lobe lesionsThromboembolic strokeBrain lesionsSuch injuriesCT scanLesion locationDepression severityLobe lesionsLesion proximityDepressive symptomatologyLesion ageFrontal poleInjuryMood changesPatientsImpairmentMood ScaleLesionsDepression