2000
MRI findings differentiate between late‐onset schizophrenia and late‐life mood disorder
Rabins P, Aylward E, Holroyd S, Pearlson G. MRI findings differentiate between late‐onset schizophrenia and late‐life mood disorder. International Journal Of Geriatric Psychiatry 2000, 15: 954-960. PMID: 11044878, DOI: 10.1002/1099-1166(200010)15:10<954::aid-gps224>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsLate-onset schizophreniaLate-life bipolar disorderBilateral cortical atrophyLarger third ventriclesRight temporal hornLate-life mood disordersLate-life depressionDegree of atrophyNormal control groupGender-matched controlsFunctional imaging studiesSulcal enlargementCortical atrophyMRI findingsTemporal hornFunctional abnormalitiesSylvian fissureMood disordersThird ventricleOutpatient servicesMRI scansPatientsAffective disordersControl groupBipolar disorder
1996
CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease
Aylward E, Rasmusson D, Brandt J, Raimundo L, Folstein M, Pearlson G. CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease. Journal Of The International Neuropsychological Society 1996, 2: 89-95. PMID: 9375193, DOI: 10.1017/s135561770000093x.Peer-Reviewed Original ResearchConceptsSuprasellar cisternAlzheimer's diseaseAD patientsCT measuresQuantitative computed tomography (CT) measuresMini-Mental State Exam scoreCT measurementsComputed tomography measuresProbable Alzheimer's diseaseState Exam scoreBicaudate ratioBifrontal ratioNeurocognitive declineLateral ventricleThird ventricleCT scanTomography measuresCognitive declineCognitive functionPatientsAdaptive functioningDiseaseScansNeuropsychological measuresCognitive functioning
1991
Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography
Cascella N, Pearlson G, Wong D, Broussolle E, Nagoshi C, Margolin R, London E. Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography. The British Journal Of Psychiatry 1991, 159: 217-221. PMID: 1773237, DOI: 10.1192/bjp.159.2.217.Peer-Reviewed Original ResearchConceptsSubstance abuseSulcal measuresCocaine useSulcal widthWider third ventriclesEffect of ageBrain atrophyBrain ratioChronic useComputerised tomographyThird ventricleNormal controlsAlcohol consumptionBrain morphologyAlcohol usePolydrug abusersSignificant predictorsAgeVentricleSeverityTomographyPositive correlationAbusePossible effectsVentricular