2020
Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features
Parker D, Trotti R, McDowell J, Keedy S, Gershon E, Ivleva E, Pearlson G, Keshavan M, Tamminga C, Sweeney J, Clementz B. Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features. Biomarkers In Neuropsychiatry 2020, 3: 100014. PMID: 36644018, PMCID: PMC9837793, DOI: 10.1016/j.bionps.2020.100014.Peer-Reviewed Original ResearchSchizoaffective disorderGroup differencesBipolar disorderAuditory paired-stimulus paradigmPaired-stimulus paradigmNeural responsesIdentification of biomarkersB-SNIPClinical featuresSignificant group differencesPsychosis subjectsBipolar-Schizophrenia NetworkPsychosis casesHealthy subjectsPreparatory periodPsychosis syndromeFrequency principal components analysisMania symptomsP50 responsePositive symptomsClinical phenotypeAffective syndromeBipolar spectrumPsychosisPutative biomarkers
2017
SA64. Hallucination Severity Predicted by Auditory Cortex Resting State Connectivity in Bipolar and Schizophrenia Network on Intermediate Phenotypes Study
Okuneye V, Meda S, Keshavan M, Sweeney J, Tamminga C, Pearlson G, Gershon E, Keedy S. SA64. Hallucination Severity Predicted by Auditory Cortex Resting State Connectivity in Bipolar and Schizophrenia Network on Intermediate Phenotypes Study. Schizophrenia Bulletin 2017, 43: s136-s136. PMCID: PMC5475960, DOI: 10.1093/schbul/sbx023.063.Peer-Reviewed Original ResearchAuditory cortexHallucination severityState connectivityPsychosis patientsSignificant negative associationIntermediate Phenotypes (B-SNIP) studySchizophrenia NetworkResting-state connectivityAbnormal activation patternsBrodmann area 22Primary auditory cortexSecondary auditory cortexRight orbitofrontal cortexPrevious functional imaging studiesPhenotype studiesClinical rating scalesAuditory processing areasPossible common pathwayFunctional imaging studiesMiddle temporal cortexNegative associationPsychosis subjectsHealthy controlsHealthy subjectsConnectivity dysfunction