2016
Poster Number: NR 28 Late-Life Major Depression and Neuroticism: A Preliminary Functional Connectivity Study
Steffens D, Wang L, Pearlson G. Poster Number: NR 28 Late-Life Major Depression and Neuroticism: A Preliminary Functional Connectivity Study. American Journal Of Geriatric Psychiatry 2016, 24: s158-s159. DOI: 10.1016/j.jagp.2016.02.031.Peer-Reviewed Original Research
2001
Cerebral blood flow in obsessive–compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders
Hoehn-Saric R, Schlaepfer T, Greenberg B, McLeod D, Pearlson G, Wong S. Cerebral blood flow in obsessive–compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders. Psychiatry Research 2001, 108: 89-100. PMID: 11738543, DOI: 10.1016/s0925-4927(01)00114-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood Flow VelocityCerebral CortexDepressive Disorder, MajorDesipramineDominance, CerebralDouble-Blind MethodFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedObsessive-Compulsive DisorderRegional Blood FlowSertralineTomography, Emission-Computed, Single-PhotonTreatment OutcomeConceptsRegional cerebral blood flowHigher regional cerebral blood flowWeeks of treatmentCerebral blood flowYale-Brown Obsessive Compulsive ScaleBlood flowTemporal regionsType of medicationEffects of sertralineMajor depressive episodePrefrontal regional cerebral blood flowAdministration of medicationsPrefrontal regionsHMPAO SPECT scansEffect of treatmentObsessive Compulsive ScaleDiffuse reductionRCBF reductionStudy entryBasal gangliaDepressive episodeClinical changesMajor depressionDrug treatmentTreatment responders
1996
Major Depression in Alzheimer's Disease An Interaction Between Gender and Family History
Lyketsos C, Tune L, Pearlson G, Steele C. Major Depression in Alzheimer's Disease An Interaction Between Gender and Family History. Journal Of The Academy Of Consultation-Liaison Psychiatry 1996, 37: 380-384. PMID: 8701017, DOI: 10.1016/s0033-3182(96)71552-9.Peer-Reviewed Original Research
1991
Centrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia
Pearlson G, Rabins P, Burns A. Centrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia. Psychological Medicine 1991, 21: 321-328. PMID: 1876637, DOI: 10.1017/s0033291700020420.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCT attenuation numbersGray matterAttenuation numberCranial CT scanLate-life depressionElderly patientsReversible dementiaPatient groupCT changesLife depressionMajor depressionCentrum semiovaleAttenuation valuesCT scanNormal controlsElderly controlsNeuropsychological evaluationNormal agingDiseasePatientsDepressionCognitive tasksDementiaReliable means
1990
Confrontation naming deficit in dementia of depression
Speedie L, Rabins P, Pearlson G, Moberg P. Confrontation naming deficit in dementia of depression. Journal Of Neuropsychiatry 1990, 2: 59-63. PMID: 2136062, DOI: 10.1176/jnp.2.1.59.Peer-Reviewed Original ResearchConceptsDementia of depressionDelayed visual memoryIrreversible dementiaMemory taskVisual memoryFree recallLanguage abilityNondepressed control subjectsDepressed patientsMemoryCognitive impairmentNormal cognitionElderly depressed patientsRecallDepressionTaskDementiaMajor depressionReversible dementiaPatient groupControl subjectsCognitionPatientsDeficitsConfrontation
1989
Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’)*
Pearlson G, Rabins P, Kim W, Speedie L, Moberg P, Burns A, Bascom M. Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’)*. Psychological Medicine 1989, 19: 573-584. PMID: 2798631, DOI: 10.1017/s003329170002417x.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationVentricular brain ratioAD patientsDepressed patientsNormal controlsDSM-III major depressionCognitive deficitsShort-term progressionStructural brain abnormalitiesCranial CT scanProbable Alzheimer's diseaseCT attenuation valuesCT valuesReversible dementiaElderly patientsMost patientsBrain ratioCT attenuation numbersCT changesElderly depressivesBrain abnormalitiesDementia syndromesMajor depressionCT scanPatients
1988
Manic Syndrome Associated With Zidovudine
Schaerf F, Miller R, Pearlson G, Kaminsky M, Weaver D. Manic Syndrome Associated With Zidovudine. JAMA 1988, 260: 3587-3588. DOI: 10.1001/jama.1988.03410240045016.Peer-Reviewed Original ResearchCases of maniaZidovudine therapySyndrome AssociatedHuman immunodeficiency virus-seropositive individualsAffective disordersImmunodeficiency syndrome dementia complexZidovudine dosageZidovudine treatmentSuch patientsDementia complexManic episodesMajor depressionFamily historyDepressive symptomsCognitive declinePsychiatric syndromesPatientsPersonal historyZidovudineTherapyEt al1ManiaDisordersAssociatedSyndrome
1984
NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY
Lipsey J, Pearlson G, Robinson R, Rao K, Price T. NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY. The Lancet 1984, 323: 297-300. PMID: 6141377, DOI: 10.1016/s0140-6736(84)90356-8.Peer-Reviewed Original ResearchConceptsPost-stroke depressionDouble-blind studyDepression ScaleEfficacy of nortriptylinePlacebo-treated patientsSerum nortriptyline levelsHamilton Depression ScalePresent State ExaminationZung Depression ScaleStroke patientsTherapeutic rangeMajor depressionNortriptyline levelsDemonstrated efficacyState ExaminationPatientsNortriptylineDepressionGreater improvementTreatmentSimilar groupsEfficacyImportant addition