2016
Subcortical volumetric abnormalities in bipolar disorder
Hibar DP, Westlye LT, van Erp TG, Rasmussen J, Leonardo CD, Faskowitz J, Haukvik UK, Hartberg CB, Doan NT, Agartz I, Dale AM, Gruber O, Krämer B, Trost S, Liberg B, Abé C, Ekman CJ, Ingvar M, Landén M, Fears SC, Freimer NB, Bearden CE, Sprooten E, Glahn D, Pearlson G, Emsell L, Kenney J, Scanlon C, McDonald C, Cannon D, Almeida J, Versace A, Caseras X, Lawrence N, Phillips M, Dima D, Delvecchio G, Frangou S, Satterthwaite T, Wolf D, Houenou J, Henry C, Malt U, Bøen E, Elvsåshagen T, Young A, Lloyd A, Goodwin G, Mackay C, Bourne C, Bilderbeck A, Abramovic L, Boks M, van Haren N, Ophoff R, Kahn R, Bauer M, Pfennig A, Alda M, Hajek T, Mwangi B, Soares J, Nickson T, Dimitrova R, Sussmann J, Hagenaars S, Whalley H, McIntosh A, Thompson P, Andreassen O. Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry 2016, 21: 1710-1716. PMID: 26857596, PMCID: PMC5116479, DOI: 10.1038/mp.2015.227.Peer-Reviewed Original ResearchConceptsLateral ventricleBipolar disorderBDII patientsBD patientsIntracranial volumeLarger thalamic volumesSubcortical volumetric abnormalitiesLarger lateral ventriclesSignificant differencesSubcortical brain measuresCase-control differencesDevelopment of biomarkersMean hippocampusVolumetric abnormalitiesIllness onsetThalamic volumeBDI patientsGlobus pallidusSmaller hippocampiClinical subtypesDisease progressionHealthy controlsBrain changesNucleus accumbensPatients
1998
Brain changes in schizophrenia
Sharma T, Lancaster E, Lee D, Lewis S, Sigmundsson T, Takei N, Gurling H, Barta P, Pearlson G, Murray R. Brain changes in schizophrenia. The British Journal Of Psychiatry 1998, 173: 132-138. PMID: 9850225, DOI: 10.1192/bjp.173.2.132.Peer-Reviewed Original ResearchConceptsLarger lateral ventriclesControl subjectsUnrelated control subjectsLateral ventricleSmaller whole brainLateral ventricular enlargementStructural brain abnormalitiesNormal control subjectsObligate carriersGenetic liabilityVentricular enlargementSample of peopleBrain abnormalitiesBrain changesWhole brainCerebellar volumeBrain structuresMagnetic resonance imagesSchizophreniaVentricleUnaffected siblingsReconstructed magnetic resonance imagesResonance imagesAbnormalitiesVolumetric measurements