2023
Identifying psychosis subtypes use individualized covariance structural differential networks and multi-site clustering
Ji Y, Pearlson G, Bustillo J, Kochunov P, Turner J, Jiang R, Shao W, Zhang X, Fu Z, Li K, Liu Z, Xu X, Zhang D, Qi S, Calhoun V. Identifying psychosis subtypes use individualized covariance structural differential networks and multi-site clustering. Schizophrenia Research 2023, 264: 130-139. PMID: 38128344, DOI: 10.1016/j.schres.2023.12.013.Peer-Reviewed Original ResearchPsychosis subtypesSchizoaffective disorderBipolar disorderClinical phenotypeFirst-degree relativesTemporal-occipital cortexAmygdala-hippocampusClinical symptomsNeuroimaging featuresBipolar-Schizophrenia NetworkBrain alterationsHealthy controlsIntermediate Phenotypes (B-SNIP) consortiumOccipital cortexDecreased connectivitySubtypesStructural covarianceFractional amplitudeSubtype IILow-frequency fluctuationsNeurobiological heterogeneityGreater predispositionPsychosis spectrumGroup differencesDiagnostic classification
2022
Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression
Wen J, Fu C, Tosun D, Veturi Y, Yang Z, Abdulkadir A, Mamourian E, Srinivasan D, Skampardoni I, Singh A, Nawani H, Bao J, Erus G, Shou H, Habes M, Doshi J, Varol E, Mackin R, Sotiras A, Fan Y, Saykin A, Sheline Y, Shen L, Ritchie M, Wolk D, Albert M, Resnick S, Davatzikos C, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Liu E, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kelley F, Kim S, Nho K, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Mason S, Albers C, Knopman D, Johnson K, Doody R, Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Leon S, Householder E, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geldmacher D, Brockington J, Roberson E, Grossman H, Mitsis E, deToledo-Morrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Albert M, Onyike C, DAgostino II D, Kielb S, Galvin J, Pogorelec D, Cerbone B, Michel C, Rusinek H, Leon M, Glodzik L, Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Ortiz C, Womack K, Mathews D, Quiceno M, Arrastia R, King R, Weiner M, Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression. JAMA Psychiatry 2022, 79: 464-474. PMID: 35262657, PMCID: PMC8908227, DOI: 10.1001/jamapsychiatry.2022.0020.Peer-Reviewed Original ResearchConceptsLate-life depressionHealthy control individualsClinical symptomsSubset of individualsControl individualsGray matter brain volumeWidespread brain atrophyWhite matter fractional anisotropyMajor depressive disorderHigher depression severityGenetic profileBrain atrophyClinical outcomesClinical manifestationsDepressive disorderPossible disease mechanismsMAIN OUTCOMEBrain agingGeneral populationDepression severityMulticenter consortiumBrain volumeCognitive impairmentMulticenter sampleAlzheimer's disease
2016
Polygenic risk of Alzheimer disease is associated with early- and late-life processes
Mormino EC, Sperling RA, Holmes AJ, Buckner RL, De Jager PL, Smoller JW, Sabuncu MR, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Polygenic risk of Alzheimer disease is associated with early- and late-life processes. Neurology 2016, 87: 481-488. PMID: 27385740, PMCID: PMC4970660, DOI: 10.1212/wnl.0000000000002922.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsAtrophyBiomarkersCognition DisordersCohort StudiesEarly DiagnosisEthylene GlycolsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHippocampusHumansMaleMemory DisordersMultifactorial InheritancePolymorphism, Single NucleotidePositron-Emission TomographyYoung AdultConceptsHigher polygenic risk scorePolygenic risk scoresHippocampus volumeRisk scoreLarge observational cohort studyCommon genetic risk lociSmaller hippocampus volumesΒ-amyloid burdenObservational cohort studyGenetic riskElevated polygenic risk scoresAlzheimer's disease markersCSF β-amyloidLongitudinal cognitive declineHealthy young participantsCohort studyClinical progressionClinical symptomsAD dementiaAD markersSmaller hippocampiFlorbetapir PETAggregate genetic riskΒ-amyloidGenome-wide association studies
1997
Sex Differences in Schizophrenia
Pearlson G, Schlaepfer T. Sex Differences in Schizophrenia. JAMA Psychiatry 1997, 54: 189-189. PMID: 9040289, DOI: 10.1001/archpsyc.1997.01830140101019.Peer-Reviewed Original ResearchConceptsClinical symptomsSex differencesPathogenesis of schizophreniaBiological risk markersEpidemiological characteristicsRisk markersEpidemiological featuresRisk factorsPathogenetic mechanismsBrain changesOnset ageSuch sex differencesReceptor hypothesisSchizophreniaSymptomsLateralization modelCortex modelDifferencesPathogenesis