2024
Cerebral Blood Flow Changes and Neuroticism in Late-Life Depression
Anderson T, Steffens D, Wang L, Pearlson G. Cerebral Blood Flow Changes and Neuroticism in Late-Life Depression. American Journal Of Geriatric Psychiatry 2024, 32: s49-s50. DOI: 10.1016/j.jagp.2024.01.121.Peer-Reviewed Original ResearchMontgomery Asberg Depression Rating ScaleLate-life depressionAsberg Depression Rating ScaleLeft putamenFrontal poleLow neuroticismGroup differencesDecreased CBFLLD subjectsDepression severityDepression groupLLD groupCerebral blood flowNever-depressed control subjectsNever-depressed healthy controlsNEO Personality InventoryNever-depressed groupDepression Rating ScaleNeuroticism personality traitFrontal lobe structuresGroup effectBrain morphological changesT1-weighted MPRAGE imagesHealthy controlsSignificant group effect
2001
Cerebral blood flow in obsessive–compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders
Hoehn-Saric R, Schlaepfer T, Greenberg B, McLeod D, Pearlson G, Wong S. Cerebral blood flow in obsessive–compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders. Psychiatry Research 2001, 108: 89-100. PMID: 11738543, DOI: 10.1016/s0925-4927(01)00114-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood Flow VelocityCerebral CortexDepressive Disorder, MajorDesipramineDominance, CerebralDouble-Blind MethodFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedObsessive-Compulsive DisorderRegional Blood FlowSertralineTomography, Emission-Computed, Single-PhotonTreatment OutcomeConceptsRegional cerebral blood flowHigher regional cerebral blood flowWeeks of treatmentCerebral blood flowYale-Brown Obsessive Compulsive ScaleBlood flowTemporal regionsType of medicationEffects of sertralineMajor depressive episodePrefrontal regional cerebral blood flowAdministration of medicationsPrefrontal regionsHMPAO SPECT scansEffect of treatmentObsessive Compulsive ScaleDiffuse reductionRCBF reductionStudy entryBasal gangliaDepressive episodeClinical changesMajor depressionDrug treatmentTreatment responders
1994
Altered cortical blood flow in HIV-seropositive individuals with and without dementia
Harris G, Pearlson G, McArthur J, Zeger S, LaFrance N. Altered cortical blood flow in HIV-seropositive individuals with and without dementia. AIDS 1994, 8: 495-500. PMID: 8011253, DOI: 10.1097/00002030-199404000-00012.Peer-Reviewed Original ResearchConceptsHIV-1-infected groupHIV-1-infected individualsNormal controlsBlood flowHIV-1-seropositive individualsRegional cerebral blood flowCortical profilesCerebral cortical perfusionCortical perfusion changesHIV-seropositive individualsCerebral perfusion abnormalitiesCortical blood flowCerebral blood flowSingle photon emissionTomographic imaging studiesHigh-frequency powerCortical perfusionCerebral cortexPerfusion abnormalitiesPerfusion changesSevere dementiaImaging studiesDistribution of radiotracerPhoton emissionDementia
1993
Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder
Harris G, Pearlson G, Hoehn-Saric R. Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder. JAMA Psychiatry 1993, 50: 498-499. PMID: 8498888, DOI: 10.1001/archpsyc.1993.01820180100015.Peer-Reviewed Original ResearchConceptsOrbital frontal regionsObsessive-compulsive disorderSingle photon emissionBlood flowRegional cerebral blood flowCortical blood flowGroup of patientsCerebral blood flowMedial frontal regionsSPECT studiesAnatomical locationPatientsCompulsive disorderPhoton emissionEt al1DisordersTomographyGroup
1991
Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography
Tune L, Brandt J, Frost J, Harris G, Mayberg H, Steele C, Burns A, Sapp J, Folstein M, Wagner H, Pearlson G. Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography. Acta Psychiatrica Scandinavica. Supplementum 1991, 83: 61-65. PMID: 1897377, DOI: 10.1111/j.1600-0447.1991.tb03111.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmphetaminesBlood GlucoseBrainCerebrovascular CirculationDeoxyglucoseDose-Response Relationship, DrugDrug Administration ScheduleFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedNeuropsychological TestsPhysostigminePilot ProjectsTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsCerebral glucose metabolismCerebral blood flowSingle photon emission tomographyPhoton emission tomographyPositron emission tomographyBlood flowEmission tomographyGlucose metabolismAlzheimer's diseaseRegional cerebral glucose metabolismSignificant clinical improvementCognitive functioningClinical improvementMost patientsIntravenous administrationPatientsDiseasePhysostigmineTomographyBrain activityPreliminary findingsMetabolismPronounced improvementPathophysiologyIllness