2000
Neurobiology of schizophrenia
Pearlson G. Neurobiology of schizophrenia. Annals Of Neurology 2000, 48: 556-566. PMID: 11026439, DOI: 10.1002/1531-8249(200010)48:4<556::aid-ana2>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsOngoing cell deathFunctional brain imaging studiesNeurobiology of schizophreniaBrain imaging studiesCommon chronicNeuropathological studiesUnknown etiologyGlutamate systemClinical expressionMigrational abnormalitiesBiochemical abnormalitiesFetal brainNicotinic receptorsEffective treatmentNumerous biological markersCerebral circuitsRegional abnormalitiesImaging studiesBrain diseasesSecond hitBiological markersAbnormal personality traitsSingle disorderSchizophreniaBiological susceptibility
1986
Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics
Wong D, Wagner H, Tune L, Dannals R, Pearlson G, Links J, Tamminga C, Broussolle E, Ravert H, Wilson A, Toung J, Malat J, Williams J, O'Tuama L, Snyder S, Kuhar M, Gjedde A. Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics. Science 1986, 234: 1558-1563. PMID: 2878495, DOI: 10.1126/science.2878495.Peer-Reviewed Original ResearchConceptsD2 dopamine receptorsD2 dopamine receptor densityPositron emission tomographyGroup of patientsDopamine receptor densityDopamine receptorsCaudate nucleusReceptor densityNormal volunteersEmission tomographyDrug-naive schizophrenicsNumber of receptorsMost patientsBasal gangliaNeuroleptic drugsPostmortem studiesBiochemical abnormalitiesPatientsPsychiatric diseasesSchizophreniaReceptorsDrugsVolunteersTomographyGroup