2023
What role does adjuvant therapy play in the management of endometrial cancer?
Huang G, Tymon-Rosario J, Santin A. What role does adjuvant therapy play in the management of endometrial cancer? Expert Opinion On Pharmacotherapy 2023, 24: 7-10. PMID: 36594708, DOI: 10.1080/14656566.2022.2157207.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
Prognostic impact of mismatch repair deficiency in high- and low-intermediate-risk, early-stage endometrial cancer following vaginal brachytherapy
Li JY, Park HS, Huang GS, Young MR, Ratner E, Santin A, Damast S. Prognostic impact of mismatch repair deficiency in high- and low-intermediate-risk, early-stage endometrial cancer following vaginal brachytherapy. Gynecologic Oncology 2021, 163: 557-562. PMID: 34602287, DOI: 10.1016/j.ygyno.2021.09.018.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalEndometrioid endometrial cancerVaginal brachytherapyPMMR patientsOverall survivalEEC patientsEndometrial cancerExact testThree-year recurrence-free survivalEarly-stage endometrial cancerCox proportional hazards regressionPoor recurrence-free survivalAdjuvant vaginal brachytherapyThree-year OSMultivariable Cox regressionLympho-vascular invasionSignificant prognostic variablesProportional hazards regressionLog-rank testKaplan-Meier estimatesDeficient mismatch repairMismatch repair statusFisher's exact testMismatch repair deficiencyDMMR status
2020
Stage III uterine serous carcinoma: modern trends in multimodality treatment
Li JY, Young MR, Huang G, Litkouhi B, Santin A, Schwartz PE, Damast S. Stage III uterine serous carcinoma: modern trends in multimodality treatment. Journal Of Gynecologic Oncology 2020, 31: e53. PMID: 32266802, PMCID: PMC7286763, DOI: 10.3802/jgo.2020.31.e53.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrachytherapyEndometrial NeoplasmsFemaleHumansHysterectomyMiddle AgedNeoplasm StagingRadiotherapy, AdjuvantRetrospective StudiesConceptsUterine serous carcinomaExternal beam RTVaginal brachytherapyOverall survivalHuman epidermal growth factor receptorModern treatment eraSentinel node samplingRegional nodal recurrenceKaplan-Meier estimatesLog-rank testCox proportional hazardsExternal beam radiotherapyEpidermal growth factor receptorERA treatmentGrowth factor receptorUSC patientsFree survivalNodal recurrenceTreatment eraMultimodality treatmentPatient characteristicsPerioperative periodRegional nodalSerous carcinomaNode sampling
2019
Neutrophilia and mortality in women with uterine carcinosarcoma
Arend R, Van Arsdale A, Gojayev A, Roane BM, Doo D, Leath C, Goldberg GL, Huang G. Neutrophilia and mortality in women with uterine carcinosarcoma. International Journal Of Gynecological Cancer 2019, 29: 1258. PMID: 31320488, DOI: 10.1136/ijgc-2019-000440.Peer-Reviewed Original ResearchConceptsPre-treatment absolute neutrophil countAbsolute neutrophil countIndependent poor prognostic factorProgression-free survivalPoor prognostic factorNeutrophil countUterine carcinosarcomaOverall survivalPrognostic factorsMultivariable Cox proportional hazards regression modelsCox proportional hazards regression modelAbsolute neutrophil count dataHigher absolute neutrophil countKaplan-Meier survival estimatesProportional hazards regression modelsUterine carcinosarcoma patientsRetrospective cohort studyHazards regression modelsLog-rank testInstitutional review boardCarcinosarcoma patientsCohort studyDisease recurrenceClinical outcomesHighest quartile
2018
In vitro and in vivo activity of IMGN853, an Antibody-Drug Conjugate targeting Folate Receptor Alpha linked to DM4, in biologically aggressive endometrial cancers
Altwerger G, Bonazzoli E, Bellone S, Egawa-Takata T, Menderes G, Pettinella F, Bianchi A, Riccio F, Feinberg J, Zammataro L, Han C, Yadav G, Dugan K, Morneault A, Ponte JF, Buza N, Hui P, Wong S, Litkouhi B, Ratner E, Silasi DA, Huang GS, Azodi M, Schwartz PE, Santin AD. In vitro and in vivo activity of IMGN853, an Antibody-Drug Conjugate targeting Folate Receptor Alpha linked to DM4, in biologically aggressive endometrial cancers. Molecular Cancer Therapeutics 2018, 17: molcanther.0930.2017. PMID: 29440294, PMCID: PMC5932245, DOI: 10.1158/1535-7163.mct-17-0930.Peer-Reviewed Original ResearchConceptsEndometrial cancerXenograft modelCell linesTumor cell linesPatient-derived xenograft modelsUterine cancer cell linesAggressive endometrial cancersEndometrial cancer deathsExpression of FRαPrimary USC cell linesRecurrent endometrial cancerReceptor alpha expressionUSC cell linesImpressive antitumor activityMol Cancer TherUSC patientsCancer cell linesMedian survivalCancer deathPDX modelsPreclinical dataUterine cancerComplete resolutionIMGN853Grade 3
2015
The impact of obesity on prostate cancer recurrence observed after exclusion of diabetics
Agalliu I, Williams S, Adler B, Androga L, Siev M, Lin J, Xue X, Huang G, Strickler HD, Ghavamian R. The impact of obesity on prostate cancer recurrence observed after exclusion of diabetics. Cancer Causes & Control 2015, 26: 821-830. PMID: 25771797, PMCID: PMC4984400, DOI: 10.1007/s10552-015-0554-z.Peer-Reviewed Original ResearchConceptsBody mass indexBMI/obesityProstate cancer recurrenceCancer recurrencePRCA patientsBeta-cell insulin productionCox proportional hazards modelExclusion of diabeticsAnti-diabetes medicationsImpact of obesityNormal-weight menPathological tumor characteristicsType 2 diabetesProportional hazards modelObese menSerum PSAAdvanced diabetesMass indexTumor characteristicsWeight menRadical prostatectomyObesity associationRecurrence eventsHazards modelObesity
2011
Performance of Serum CA125 as a Prognostic Biomarker in Patients With Uterine Papillary Serous Carcinoma
Gupta D, Gunter MJ, Yang K, Lee S, Zuckerwise L, Chen LM, Goldberg GL, Huang GS. Performance of Serum CA125 as a Prognostic Biomarker in Patients With Uterine Papillary Serous Carcinoma. International Journal Of Gynecological Cancer 2011, 21: 529-534. PMID: 21436701, DOI: 10.1097/igc.0b013e31821091b5.Peer-Reviewed Original ResearchConceptsUterine papillary serous carcinomaPapillary serous carcinomaCA125 levelsLymph node metastasisDisease recurrenceCA125 elevationMetastatic diseaseNode metastasisSerum CA125Serous carcinomaStage III/IV diseaseCox proportional hazards regression modelingProportional hazards regression modelingElevated CA125 levelsPreoperative CA125 levelsLymph node involvementRecurrence-free survivalAdvanced International FederationMultivariate survival analysisUPSC patientsMean followSurgical stagingCA125 measurementNode involvementIndependent predictors
2005
Total laparoscopic hysterectomy versus total abdominal hysterectomy: cohort review of patients with uterine neoplasia.
O'Hanlan KA, Huang GS, Garnier AC, Dibble SL, Reuland ML, Lopez L, Pinto RL. Total laparoscopic hysterectomy versus total abdominal hysterectomy: cohort review of patients with uterine neoplasia. JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 2005, 9: 277-86. PMID: 16121872, PMCID: PMC3015616.Peer-Reviewed Original ResearchConceptsTotal laparoscopic hysterectomyUterine neoplasiaTAH groupBlood lossLaparoscopic hysterectomyTAH patientsTotal abdominal hysterectomy patientsSimilar body mass indexAbdominal hysterectomy patientsBulky metastatic diseaseTotal abdominal hysterectomyAverage blood lossLess blood lossBody mass indexClinical selection criteriaAbdominal hysterectomyHospital stayNode dissectionChart abstractionCohort reviewMetastatic diseaseSelect patientsEndometrial pathologyHysterectomy patientsLaparoscopic approach
2004
Total laparoscopic hysterectomy for oncological indications with outcomes stratified by age
O'Hanlan KA, Huang GS, Lopez L, Garnier AC. Total laparoscopic hysterectomy for oncological indications with outcomes stratified by age. Gynecologic Oncology 2004, 95: 196-203. PMID: 15385132, DOI: 10.1016/j.ygyno.2004.07.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overFemaleGenital Neoplasms, FemaleHumansHysterectomyLaparoscopyMiddle AgedRetrospective StudiesTreatment OutcomeConceptsTotal laparoscopic hysterectomyBody mass indexOvarian carcinomaAdhesive bowel obstructionEarly ovarian carcinomaFamilial ovarian carcinomaMean blood lossOverall complication rateComplex pelvic massChi-square testUrologic complicationsBowel obstructionHospital stayComplication rateBlood lossCervical dysplasiaEndometrial neoplasiaLaparoscopic hysterectomyMass indexVaginal carcinomaPelvic massPreoperative diagnosisSurgical durationSurgical outcomesOncological indicationsSelective incorporation of total laparoscopic hysterectomy for adnexal pathology and body mass index
O'Hanlan KA, Huang GS, Lopez L, Garnier AC. Selective incorporation of total laparoscopic hysterectomy for adnexal pathology and body mass index. Gynecologic Oncology 2004, 93: 137-143. PMID: 15047227, DOI: 10.1016/j.ygyno.2003.12.020.Peer-Reviewed Original ResearchConceptsTotal laparoscopic hysterectomyBody mass indexAdnexal pathologyUrological injuriesLaparoscopic hysterectomyBMI groupsMass indexOvarian carcinomaExact testRecurrent breast cancerMean surgery durationMean complication rateFisher's exact testObstructive adhesionsEarly complicationsHospital stayStage IAChart abstractionComplication rateNodal yieldBlood lossOvarian pathologyMucinous cystadenomaPelvic massMean age
2003
Total laparoscopic hysterectomy: body mass index and outcomes.
O'Hanlan KA, Lopez L, Dibble SL, Garnier AC, Huang GS, Leuchtenberger M. Total laparoscopic hysterectomy: body mass index and outcomes. Obstetrics And Gynecology 2003, 102: 1384-92. PMID: 14662231, DOI: 10.1016/j.obstetgynecol.2003.08.018.Peer-Reviewed Original ResearchMeSH KeywordsBody Mass IndexFemaleHumansHysterectomyLaparoscopyMiddle AgedPostoperative ComplicationsRetrospective StudiesTreatment OutcomeConceptsTotal laparoscopic hysterectomyBody mass indexLaparoscopic hysterectomyBMI groupsHospital stayBlood lossComplication rateMass indexOccult ovarian carcinomaTotal complication rateShorter hospital stayMinor complication rateMinimal blood lossOperating timeOverweight-25Urologic injuryAbdominal surgeryBMI categoriesInvasive hysterectomyLaparoscopic approachPatient seriesRetrospective reviewMean ageOvarian carcinomaMinimal operating time