2020
Preclinical activity of sacituzumab govitecan (IMMU-132) in uterine and ovarian carcinosarcomas
Lopez S, Perrone E, Bellone S, Bonazzoli E, Zeybek B, Han C, Tymon-Rosario J, Altwerger G, Menderes G, Bianchi A, Zammataro L, Manzano A, Manara P, Ratner E, Silasi DA, Huang GS, Azodi M, Schwartz PE, Raspagliesi F, Angioli R, Buza N, Hui P, Bond HM, Santin AD. Preclinical activity of sacituzumab govitecan (IMMU-132) in uterine and ovarian carcinosarcomas. Oncotarget 2020, 11: 560-570. PMID: 32082489, PMCID: PMC7007291, DOI: 10.18632/oncotarget.27342.Peer-Reviewed Original ResearchSacituzumab govitecanTrop-2 expressionTrop-2Ovarian carcinosarcomaWeekly intravenous administrationSignificant tumor growth inhibitionTumor growth inhibitionCS cell linesCell linesCell surface markersNegative cell linesAggressive carcinosarcomasCarcinosarcoma patientsPrimary carcinosarcomaOverall survivalPoor prognosisPreclinical activityRare cancersIntravenous administrationXenograft modelActive drugCarcinosarcomaActive metaboliteFFPE tumorsCell viability assays
2019
Neutrophilia and mortality in women with uterine carcinosarcoma
Arend R, Van Arsdale A, Gojayev A, Roane BM, Doo D, Leath C, Goldberg GL, Huang G. Neutrophilia and mortality in women with uterine carcinosarcoma. International Journal Of Gynecological Cancer 2019, 29: 1258. PMID: 31320488, DOI: 10.1136/ijgc-2019-000440.Peer-Reviewed Original ResearchConceptsPre-treatment absolute neutrophil countAbsolute neutrophil countIndependent poor prognostic factorProgression-free survivalPoor prognostic factorNeutrophil countUterine carcinosarcomaOverall survivalPrognostic factorsMultivariable Cox proportional hazards regression modelsCox proportional hazards regression modelAbsolute neutrophil count dataHigher absolute neutrophil countKaplan-Meier survival estimatesProportional hazards regression modelsUterine carcinosarcoma patientsRetrospective cohort studyHazards regression modelsLog-rank testInstitutional review boardCarcinosarcoma patientsCohort studyDisease recurrenceClinical outcomesHighest quartile