2022
17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury
Kim AS, Werlin EC, Kagaya H, Chen M, Wu B, Mottola G, Jan M, Conte MS. 17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury. PLOS ONE 2022, 17: e0264217. PMID: 35226675, PMCID: PMC8884511, DOI: 10.1371/journal.pone.0264217.Peer-Reviewed Original ResearchConceptsSpecialized lipid mediatorsNeointimal hyperplasiaVascular injuryRAW 264.7 cellsEndothelial cellsCarotid angioplastyPhagocytic activityAcute arterial injuryPro-resolving activitiesAcute vascular injuryCytokine-stimulated endothelial cellsP65 nuclear translocationAnti-migratory activityMurine RAW 264.7 cellsArterial injuryPersistent inflammationResolvin D1Ki67 expressionNeointimal areaSimilar efficacyLeukocyte recruitmentRat modelKi-67Lipid mediatorsNuclear translocation assays
2019
Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model
Mottola G, Werlin EC, Wu B, Chen M, Chatterjee A, Schaller MS, Conte MS. Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model. Prostaglandins And Other Lipid Mediators 2019, 146: 106401. PMID: 31841663, PMCID: PMC7265259, DOI: 10.1016/j.prostaglandins.2019.106401.Peer-Reviewed Original ResearchConceptsIntimal hyperplasiaResolvin D1Post-operative day 3Phagocytosis activityRat carotid angioplasty modelCAMP levelsLocal inflammatory responsePro-inflammatory genesArterial inflammationCarotid angioplastyOral gavageAcute inflammationVascular injuryThoracic aortaAngioplasty modelEarly inflammationInflammatory responseOral administrationPlasma concentrationsCarotid arteryRvD1Lipid mediatorsAnimal modelsDay 3Inflammation
2018
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model
Wu B, Werlin EC, Chen M, Mottola G, Chatterjee A, Lance KD, Bernards DA, Sansbury BE, Spite M, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model. Journal Of Vascular Surgery 2018, 68: 188s-200s.e4. PMID: 30064835, PMCID: PMC6252159, DOI: 10.1016/j.jvs.2018.05.206.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsBlood Vessel Prosthesis ImplantationCarotid Artery, CommonCell ProliferationChemotaxis, LeukocyteDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersFemaleGelsGraft Occlusion, VascularHyperplasiaJugular VeinsNeointimaPoloxamerPolylactic Acid-Polyglycolic Acid CopolymerRabbitsTime FactorsConceptsRabbit vein graft modelLocal perivascular deliveryVein graftsPerivascular deliveryVein graft modelNeointimal hyperplasiaResolvin D1Macrophage infiltrationLipid mediatorsSpecialized proresolving lipid mediatorsGraft modelTotal leukocyte infiltrationMajor wound complicationsProresolving lipid mediatorsVein bypass graftsD-series resolvinsNew Zealand white rabbitsPotential therapeutic roleIpsilateral jugular veinCell proliferationZealand white rabbitsExcessive neointimal hyperplasiaVein graft hyperplasiaPerivascular fashionRvD1 treatment
2017
Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications
Wu B, Mottola G, Schaller M, Upchurch GR, Conte MS. Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications. Molecular Aspects Of Medicine 2017, 58: 72-82. PMID: 28765077, PMCID: PMC5660644, DOI: 10.1016/j.mam.2017.07.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpecialized pro-resolving lipid mediatorsVascular injuryLipid mediatorsVSMC migrationPro-resolving lipid mediatorsVascular smooth muscle cell activationSmooth muscle cell activationSpecialized lipid mediatorsAcute vascular injuryElaboration of cytokinesDisease-related eventsEndothelial cell disruptionMuscle cell activationImportant clinical contextsClearance of debrisMatrix protein depositionLeukocyte effluxBypass GraftingBypass surgeryBalloon angioplastyLeukocyte recruitmentAneurysm formationInflammatory signalsExperimental aneurysm formationLumen compromise
2016
Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device
Lance KD, Chatterjee A, Wu B, Mottola G, Nuhn H, Lee PP, Sansbury BE, Spite M, Desai TA, Conte MS. Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device. Journal Of Biomedical Materials Research Part A 2016, 105: 31-41. PMID: 27508346, PMCID: PMC5124518, DOI: 10.1002/jbm.a.35861.Peer-Reviewed Original ResearchConceptsResolvin D1Rat carotid artery modelProresolving lipid mediatorsHuman vascular endothelialNF-κB activationSmooth muscle cellsCarotid artery modelTissue injuryEvidence of cytotoxicityRvD1Lipid mediatorsRabbit aortaVSMC migrationMuscle cellsFlow chamber systemBlood vesselsLocal deliveryVascular endothelialArtery modelRelevant levelsVivoTissueD1Vascular tissueDaysPerivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury
Wu B, Mottola G, Chatterjee A, Lance KD, Chen M, Siguenza IO, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury. Journal Of Vascular Surgery 2016, 65: 207-217.e3. PMID: 27034112, PMCID: PMC5040608, DOI: 10.1016/j.jvs.2016.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsAortaCardiovascular AgentsCarotid Artery DiseasesCell MovementCell ProliferationCells, CulturedCytoskeletonDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersDrug CompoundingHyperplasiaInflammation MediatorsKi-67 AntigenLactic AcidMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaOxidative StressPoloxamerPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRats, Sprague-DawleyTime FactorsTranscription Factor RelAConceptsLocal perivascular deliveryPerivascular deliveryRat modelCarotid angioplastyNeointimal hyperplasiaResolvin D1Inflammatory pathwaysNeointimal formationArterial smooth muscle cell proliferationNuclear factor-κB activationEffects of RvD1Smooth muscle cell proliferationKi67 proliferation indexResolution of inflammationNegative vessel remodelingMuscle cell proliferationSmooth muscle cellsMuscle cell responseWrap groupArterial injuryRat aortaEvidence of cytotoxicityRvD1Lipid mediatorsProliferation index
2013
D‐series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury
Miyahara T, Runge S, Chatterjee A, Chen M, Mottola G, Fitzgerald JM, Serhan CN, Conte MS. D‐series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. The FASEB Journal 2013, 27: 2220-2232. PMID: 23407709, PMCID: PMC3659350, DOI: 10.1096/fj.12-225615.Peer-Reviewed Original ResearchConceptsD-series resolvinsVascular injuryLipid mediatorsNeointimal hyperplasiaBalloon-injured rabbit arteriesMonocyte adhesionVascular smooth muscle cell activationSuperoxide productionSmooth muscle cell activationSpecialized lipid mediatorsExpression of receptorsProinflammatory gene expressionDose-dependent inhibitionMuscle cell activationVascular smooth muscle cell phenotypeSmooth muscle cell phenotypeMuscle cell phenotypeArterial angioplastyLeukocyte recruitmentHuman VSMCsVSMC proliferationGene expression assaysRabbit arteriesVascular homeostasisRvD2